2015
DOI: 10.20473/j.djmkg.v48.i2.p53-58
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Expression of bone morphogenetic protein-2 after using chitosan gel with different molecular weight on wound healing process of dental extraction

Abstract: Background: Bone morphogenetic protein-2 (BMP-2) is bone stimulator which capable of inducing differentiation of mesenchymal cells into osteoblast, stimulating bone formation in wound healing process of dental extraction. Chitosan is polymer composed N-acetyl-D-glucosamine unit that has been used in various applications

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Cited by 5 publications
(5 citation statements)
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“…Chitosan as a natural biopolymer containing glycosaminoglycans is known not only to have unique properties, biocompatible and biodegradable characteristics but also to be able to stimulate the release of important growth factors in bone healing such as FGF, PDGF, TGF-β1, VEGF, BMP-2 and collagen type 1. 8,9,26 Hence, in this study the VEGF expressions and the width of woven alveolar bone areas on 7 and 14 days in the groups with the administration of the chitosan scaffold and those in the groups with the administration of chitosan-Aloe vera scaffold were increasing and significantly different from those in the control groups. The results of this study also revealed that VEGF expressions and the width of woven alveolar bone areas on 7 and 14 days in the groups with the administration of chitosan-Aloe vera scaffold were significantly different from those in the control groups and the groups with the administration of the chitosan scaffold.…”
Section: Vegf Expressionsmentioning
confidence: 54%
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“…Chitosan as a natural biopolymer containing glycosaminoglycans is known not only to have unique properties, biocompatible and biodegradable characteristics but also to be able to stimulate the release of important growth factors in bone healing such as FGF, PDGF, TGF-β1, VEGF, BMP-2 and collagen type 1. 8,9,26 Hence, in this study the VEGF expressions and the width of woven alveolar bone areas on 7 and 14 days in the groups with the administration of the chitosan scaffold and those in the groups with the administration of chitosan-Aloe vera scaffold were increasing and significantly different from those in the control groups. The results of this study also revealed that VEGF expressions and the width of woven alveolar bone areas on 7 and 14 days in the groups with the administration of chitosan-Aloe vera scaffold were significantly different from those in the control groups and the groups with the administration of the chitosan scaffold.…”
Section: Vegf Expressionsmentioning
confidence: 54%
“…8 One percent of chitosan gel is also known to be able to increase bone morphogenetic protein-2 (BMP-2) expressions of Rattus norvegicus during bone formation after tooth extraction on 7, 14 and 21 days. 9 Aloe vera is a natural plant that can be used as a biogenic stimulator to stimulate and accelerate alveolar bone regeneration. Aloe vera has active compounds that play a role in the bone healing process.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, diphosphorylation and active BMPR will activate R-Smad to increase osteogenesis and stem cell differentiation. 18 The BMP-BMPR complex can act on transforming growth factor kinase 1 (TAK1) via osteopontin to activate the p38-MAPK signaling pathways and increase the expression of osteocalcin, osteocytes, and the other factors that accelerate bone formation. On the other hand, hyperglycemia is associated with decreased BMP expression, inhibition of mesenchymal stem cell differentiation into osteoblasts, and decreased bone formation by encouraging adipogenesis of mesenchymal stem cells by activating peroxidase proliferator-activated receptor-gamma (PPARγ) which decreases bone formation and mass.…”
Section: Discussionmentioning
confidence: 99%
“…Based on previous studies, chitosan plays a role in the bone healing process by increasing the infiltration of inflammatory cells in the trauma area and releasing growth factors. Chitosan can increase osteoblast migration and differentiation, and indirectly facilitate the process 21 . The Nacetylglucosamine component in chitosan which is also found in glycosaminoglycans supports the ability of chitosan to interact with growth factors, receptors, and adhesion proteins 22 . In this study, the results showed that the application of the C-G:CHA scaffold could increase the number of osteoblasts on days 7 and 14.…”
Section: Discussionmentioning
confidence: 99%
“…The results obtained were an increase in BMP-2 expression on days 7 and 14 and a decrease on days 21. As is known, BMP-2 is an important factor in the process of maturation and activity of osteoblasts, because of its ability to induce bone formation 21 . The findings in this study, which are supported by the studies mentioned above indicate that the application of scaffolds with chitosan-gelatin carbonate as the basis hydroxyapatite (C-G:CHA) can accelerate the process of bone regeneration.…”
Section: Discussionmentioning
confidence: 99%