Alterations in oxidative stress markers in laryngeal carcinoma patients

Bozan, Nazım; Demır, Halit; Gürsoy, Tülay; Özkan, Hüseyin; Düzenli, Ufuk; Sarıkaya, Eren; Turan, Mahfuz; Kıroğlu, Ahmet Faruk; Çankaya, Hakan

doi:10.1016/j.jcma.2018.02.004

Cited by 11 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GPx activity is associated with an increased risk of major adverse cardiovascular events at 1 year following an acute coronary syndrome. Serum GSHPx and arylesterase activity levels increased significantly after laryngectomy [87]. In a study [88], a decrease in GSH-Px activity was observed in patients with colon cancer.…”

Section: Glutathione Peroxidasementioning

confidence: 94%

Glutathione Peroxidase in Health and Diseases

Sarıkaya¹,

Doğan²

2020

Glutathione System and Oxidative Stress in Health and Disease

Self Cite

View full text Add to dashboard Cite

The aim of this study is to give information to readers about the importance of glutathione peroxidase. The physiopathology of most diseases is not fully elucidated currently; however, in many epidemiological studies, there are limited studies indicating the relationship between low levels of glutathione peroxidase status and the rise of cancer risk in many types of cancer. Anytime, situations in case of the distortion due to imbalance between enzymatic and nonenzymatic antioxidants and oxidants which lost one of paired electrons in the atomic level mean reactive oxygen species (ROS) withal reactive nitrogen species (RNS) in favor of oxidants that are related to oxidative stress. The possible mechanisms of glutathione peroxidase have been reviewed using the major findings of more than 1000 papers related to the ROS, glutathione peroxidase, and oxidative stress. Oxidative stress plays an important role in the occurrence and development of most diseases in both animal and human studies. Moreover, antioxidants have protective effects against nearly 50 disease pathogenesis. Oxidative stress, which occurs as an outcome of lipid peroxidation, concurrently may have a key importance in the phase of carcinogenesis occurring with a multistage course devoted to environmental toxicity and in cancer pathogenesis.

show abstract

Section: Glutathione Peroxidasementioning

confidence: 94%

Glutathione Peroxidase in Health and Diseases

Sarıkaya¹,

Doğan²

2020

Glutathione System and Oxidative Stress in Health and Disease

Self Cite

View full text Add to dashboard Cite

show abstract

“…Doğan et al [14] found the values of total oxidative stress parameters to be significantly higher in malignant head and neck tumors than in benign tumors. Bozan et al [15] demonstrated a significant decrease in serum antioxidants including superoxide dismutase, glutathione peroxidase, catalase, and paraoxonase with an increase of serum malondialdehyde in patients with laryngeal cancer. The authors concluded that the oxidant/antioxidant balance shifted toward oxidative stress in laryngeal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress indicators have been previously investigated in head and neck tumors including larynx carcinoma in different studies. [10,14,15] Kumar et al [10] measured the val-ue of salivary total antioxidant capacity, glutathione, and free radicals including reactive nitrogen species and reactive oxygen species (ROS) in 100 patients with squamous cell carcinoma (SCC) of the head and neck. The findings of their study revealed an oxidant/antioxidant imbalance, which indicates a significant role of oxidative stress in SCC of the head and neck.…”

Section: Discussionmentioning

confidence: 99%

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

Çetin¹,

Düzenli²,

Berköz³

et al. 2020

ENT Updates

Self Cite

View full text Add to dashboard Cite

Objective: 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F 2α (8-iso-PGF 2α) are indicators of oxidative stress in the human body. The aim of the present study was to investigate serum 8-OHdG and 8-iso-PGF 2α levels in patients with larynx carcinoma and to compare them with healthy controls. Methods: A total of 50 patients, consisting of 25 patients with larynx carcinoma (study group) and 25 healthy subjects (control group), were enrolled in the present study. Serum 8-OHdG concentration was measured using an ELI-SA kit, whereas an enzyme immunoassay kit was utilized for the measurement of serum 8-iso-PGF 2α levels. TNM stages of the patients were recorded from the patient records in the study group. Results: 8-OHdG and 8-iso-PGF 2α levels were significantly higher in patients with larynx carcinoma than the control subjects. 8-OHdG levels were significantly higher in patients with LN metastases than the patients without LN metastases in the study group. Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF 2α levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.

show abstract

“…The signal transduction pathways involved in the modulation of PON1 are PKC, p44/42 and MAPK/ERK, and these pathways are activated by growth factors and other effectors to regulate cell growth and differentiation, apoptosis and angiogenesis [28]. Moreover, in individuals who have been treated for cancer, oxidative stress markers decreased, and the activities of the enzymes antioxants, superoxide dismutase, catalase, paraoxonase-1 higher [186]. The high expression of PON-1 in the liver of older people is important, since this population makes use of large amount of drugs which are metabolized by the liver, and the damage caused by the injury of the hepatic tissue due to the inflammation and oxidative stress can lead to hepatocellular carcinoma [187].…”

Section: Paraoxonases and Cancermentioning

confidence: 99%

Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview

2019

View full text Add to dashboard Cite

Aging is defined as the accumulation of progressive organ dysfunction. There is much evidence linking the involvement of oxidative stress in the pathogenesis of aging. With increasing age, susceptibility to the development of diseases related to lipid peroxidation and tissue injury increases, due to chronic inflammatory processes, and production of reactive oxygen species (ROS) and free radicals. The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3) that share considerable structural homology and are located adjacently on chromosome 7 in humans. The most studied member product is PON1, a protein associated with high-density lipoprotein with paraoxonase/esterase activity. Nevertheless, all the three proteins prevent oxidative stress. The major aim of this review is to highlight the importance of the role of PON enzymes in the aging process, and in the development of the main diseases present in the elderly: cardiovascular disease, diabetes mellitus, neurodegenerative diseases, and cancer.

show abstract

Alterations in oxidative stress markers in laryngeal carcinoma patients

Abstract: In patients with laryngeal cancer, the oxidant/antioxidant balance shifted toward oxidative stress. In addition, following laryngectomies, laryngeal cancer patients had increases in serum antioxidant enzyme activities and decreases in oxidative stress markers.

Cited by 11 publications

References 28 publications

Glutathione Peroxidase in Health and Diseases

Glutathione Peroxidase in Health and Diseases

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview

Contact Info

Product

Resources

About