Aloe Vera Gel and Cesarean Wound Healing; A Randomized Controlled Clinical Trial

Abstract

Background:Failure in complete healing of the wound is one of the probable complications of cesarean. The present study aimed to determine the effectiveness of dressing with aloe vera gel in healing of cesarean wound.Methods:This prospective randomized double-blind clinical trial was conducted on 90 women who had undergone cesarean operation in Amir-al-Momenin hospital (Gerash, Iran). The participants were randomly divided into two groups each containing 45 patients. In one group, the wound was dressed with aloe vera gel, while simple dressing was used in the control group. Wound healing was assessed 24 hours and 8 days after the cesarean operation using REEDA scale. The data were analyzed through Chi-square and t-test.Results:The participants’ mean age was 27.56±4.20 in the aloe vera group and 26.62±4.88 in the control group, but the difference was not statistically significant. However, a significant difference was found between the two groups concerning body mass index, heart rate, and systolic blood pressure (P<0.05). Also, a significant difference was observed between the two groups with respect to the wound healing score 24 hours after the operation (P=0.003). After 8 days, however, the difference in the wound healing score was not significant (P=0.283). Overall, 45 participants in the aloe vera group and 35 ones in the control group had obtained a zero score 24 hours after the operation. These measures were respectively obtained as 42 and 41eight days after the operation.Conclusion:According to the findings of this study, the women are recommended to be informed regarding the positive effects of dressing with aloe vera gel.

Aloe vera delays mortality, but does not attenuate kidney injury in septic mices

“…The CLP model of sepsis has been a mainstay of basic sepsis research; Some medicinal plants have been tested in that model [9,[18][19][20][21], most with encouraging result; however, the aloe has been used therapeutically for many centuries and has the advantage of clinical studies demonstrating its safety and effectiveness in several diseases [22][23][24], facilitating the translation. However, more studies are necessary to assess variables of drug administration such as: the best routes of administration (oral, subcutaneous, intraperitoneal or intravenous) and dose and frequency of administration for better results [18,19].…”

O uso do Aloe sp (aloe vera) em feridas agudas e crônicas: revisão integrativa

“…Já com relação aos efeitos adversos, cinco estudos (13,15,(17)(18)(19) informaram que os pacientes não apresentaram quaisquer complicações e reações alérgicas em decorrência da aplicação da cobertura de Aloe vera.…”

“…Conforme o quadro 2, o estudo 01 foi conduzido com 90 mulheres divididas em dois grupos com a finalidade de determinar a eficácia do gel de Aloe vera na cicatrização de feridas cirúrgi-cas de cesariana (13). No grupo de intervenção o gel de Aloe foi aplicado diretamente sobre a ferida suturada e coberto com gaze seca.…”

“…Após busca na literatura, foram incluídos sete ensaios clínicos com tamanho amostral médio de 62 pacientes. Destes, cinco estudos evidenciaram que Aloe vera diminui o tempo de cicatrização da ferida quando comparados com o grupo controle, ou seja, grupo com gaze seca sem agente tópico (13), grupo com sulfadiazina de prata (15,16) e grupo com creme de placebo (18,19).…”

“…Estudo realizado com pessoas com feridas infectadas e não cicatrizadas de cesariana e de cirurgia abdominal ginecológica, Aloe vera causou um atraso na cicatrização de feridas (23). Isto pode ser devido à diferença no método do estudo e do tipo de feridas dos pacientes, tendo em vista que usaram uma escala avaliação de cicatrização de feridas diferente do estudo incluído na revisão (13).…”