Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs

Meepagala, Kumudini M.; Schrader, Kevin K.; Wedge, David E.; Duke, Stephen O.

doi:10.1016/j.phytochem.2005.09.019

Cited by 89 publications

(50 citation statements)

References 29 publications

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“…Ruta graveolens L., Rutaceae, have different established effects like antimicrobial, cytotoxic (Ivanova et al, 2005), fungicide (Meepagala et al, 2005), antiinflammatory (Raghav et al, 2006) and hypotensive properties. It is one of the most ancient and effective contraceptive plants (Maurya et al, 2004;de Freitas et al, 2005).…”

Section: Few Ethnopharmacological Surveys Amongmentioning

confidence: 99%

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Negri¹,

Rodrigues²

2010

Rev. bras. farmacogn.

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RESUMO: "Óleos essenciais encontrados na fumaça do ¨tira-capeta¨, um cigarro utilizado pelos quilombolas que vivem no pantanal do Brasil". Pesquisa etnofarmacológica realizada entre os quilombolas que vivem na Sesmaria Mata-Cavalos, no Estado de Mato Grosso, Brasil, um cigarro conhecido como ¨tira-capeta¨, foi citado por melhorar a memória e cognição, além de possuir outras indicações terapêuticas, tais como, "contra a sinusite", "para evitar resfriado", e "para aliviar problemas de insônia". No presente estudo, foi feita a caracterização dos óleos essenciais liberados durante o aquecimento das plantas utilizadas na confecção do cigarro, usando um método simples, rápido e livre de solvente baseado em cromatografia gasosa acoplada a espectrometria de massas usando "headspace" e microextração em fase sólida. Os principais constituintes encontrados foram 1,8-cineol, cânfora e α-pineno. Na tentativa de correlacionar a atividade biológica desses constituintes com as indicações terapêuticas relatadas pelos quilombolas, encontramos vários trabalhos realizados por diversos autores que mostraram que estes óleos possuem atividades similares às indicações terapêuticas relatadas pelos quilombolas.Unitermos: Etnofarmacologia, óleos essenciais, medicina popular, sistema nervoso central, quilombolas, memória. ABSTRACT: An ethnopharmacological survey developed among quilombolas living in SesmariaMata-Cavalos, in the State of Mato Grosso, Brazil; a cigarette known as "tira-capeta" (removingthe-devil), had been cited mainly "to improve memory and cognition", and also showed other therapeutical indications, such as: "against sinusitis", "to avoid cold", "to relieve sleep problems". The purpose of the present study was carried out a screening of essential oils delivered in the heating of plants used to produce the "tira-capeta" cigarette, using a simple, rapid and solvent-free method based on gas chromatography-mass spectrometry and headspace solid-phase microextraction. The principal essential oils found were 1,8 cineole, camphor and α-pinene. In the tentative to correlate these constituents with therapeutical indications reported by the quilombolas, were found some works carried out by many authors that corroborated the therapeutical indications reported by the quilombolas.

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Section: Few Ethnopharmacological Surveys Amongmentioning

confidence: 99%

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Negri¹,

Rodrigues²

2010

Rev. bras. farmacogn.

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“…R. graveolens and M. paniculata considered the most important traditional medicine in Rutaceae family [3]. They have antidiabetic, antifungal, antiandrogenic, antirheumatic pain, contraceptive, anti-hangover, antidote and insecticide effects [4][5][6][7][8][9][10][11][12]. Rutaceace popular with its secondary metabolites such as; alkaloids (graveoline, dictamnine, γ-fagarine, skimmianine, rutalinium and furacridone); coumarins (bergaptene); flavonoids (rutin); essential oil (2-undecyl acetate, 2-nonylacetate and 2-nonanone) [13].…”

Section: Introductionmentioning

confidence: 99%

Sterols Bioactivity of Ruta Graveolens L. And Murraya Paniculata L.

Baker

Ibrahim

Kandeil

et al. 2017

Int J Pharm Pharm Sci

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Objective: Ruta graveolens L. (R. graveolens) and Murraya paniculata L. (M. paniculata) are medicinal plants belonging to Rutaceae family have many uses in traditional medicine. The aim of the present study was to investigate sterols bioactivity of the two Rutaceae plant leaves.Methods: Sterols of the two Rutaceae plant leaves were identified using GC/MS. The antioxidant activities of the sterols of these herbs were evaluated by three different methods; free radical scavenging using 2,2′-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), 1,1-Diphenyl-2-picryl-hydrazyl ( Results: GC/MS assay showed β-Sitosterol (36%) as the most abundant sterols of R. graveolens followed by stigmasterol (18%), while stigmasterol (25.2%) was the most abundant one of M. paniculata steroids. The anti-inflammatory potential of R. graveolens steroids was significantly higher than that of diclofenac sodium (standard drug). M. paniculata sterols have higher antiviral activity (IC DPPH) and total antioxidant activity. The anticancer activity of the sterols was determined by MTT assay against colorectal cancer HCT116, breast cancer MCF7, liver cancer HepG2 and lung cancer A549 cell lines. Anti-inflammatory activity was evaluated using albumin denaturation assay and antiviral activities against H5N1 virus were carried out using plaque reduction assay. 50= 0.15 of µg/ml) than R. graveolens sterols (IC50 Conclusion:The current study suggests that the sterols of M. paniculata have more anti-viral activity than R. graveolens sterols which showed more anticancer and anti-inflammatory activities. = 7.8 of µg/ml). The sterols of R. graveolens showed anticancer activity against MCF7 and A549 cells with inhibition 84.3 and 81%, at 100 µg/ml respectively. While M. paniculata sterols showed 77.3% inhibition against A549 cells.

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“…The presence of secondary metabolites such as coumarins, alkaloids, terpenes flavonoids and other compounds in R. graveolens has been reported [8]. There are many reports are available for its volatile oil composition and it exhibited various biological activities such as hepatotoxicity, anti-oxidant, anti-inflammatory, cytotoxic, antitumor, antimicrobial, antifungal, anti-conceptive and anti-fertility activity [9][10][11][12][13][14][15][16] of various extracts of R. graveolens in different origins. In India, Western Ghat Region is one of the hotspot region and most promising area for its different agroclimate and enormous wealth of economically important medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Gc-MS Analysis and in Vitro Antioxidant Activities of Ruta Graveolens L. From Western Ghats Region –South India

Kathirvel¹,

Poonkodi²,

Gomathi³

et al. 2017

Asian J Pharm Clin Res

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Objective: The present study examines the chemical composition of essential oil of Ruta graveolens and antioxidant activity of petroleum ether and methanol extracts of dry leaves of R. graveolens which belongs to Rutaceae family found in many parts of the India. There are few reports are available for its essential oil in India. Methods:The fresh leaves were hydrodistilled by Clevenger type apparatus, the obtained essential oil was analyzed using gas chromatography-mass spectrometry (GC-MS). The petroleum ether and methanol extracts were tested for antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) methods. Results:The GC-MS results showed that 2-nonanol (34.25), 2-nonanone (32.15) and nonyl ester (15.43) are the major components and some of the other minor compounds are 2-dodecanone (2.77), tridecanone (2.54) and tumeronol (2.16). The preliminary phytochemical investigation of petroleum ether and methanol extracts showed the presence of carbohydrates, phenolic compounds, flavonoids, furanocoumarins, fatty acids and alkaloids. Hence, an attempt was made to find the possible sources for future novel antioxidants in food and pharmaceutical formulations. Conclusions:GC-MS studies indicated that 2-nonanone (32.15) and nonyl ester (15.43) are the major components. The methanol extract showed highest inhibitory concentration values for DPPH (19.50±1.25 µg/ml) and ABTS (48.32±0.9 µg/ml) and petroleum ether extract showed moderate activity, both results are comparable with standard employed for each method.

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Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs

Cited by 89 publications

References 29 publications

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Sterols Bioactivity of Ruta Graveolens L. And Murraya Paniculata L.

Gc-MS Analysis and in Vitro Antioxidant Activities of Ruta Graveolens L. From Western Ghats Region –South India

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