Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of
Ruta Graveolens
leads to an
in vitro
inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination
in vivo
. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in
in vitro
and
in vivo
models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of
Ruta graveolens
and reinforce its interest as complementary medicine in oncology.