Alcohol Consumption and Risk of Atrial Fibrillation in Men and Women

Abstract

Background-The relationship of the full range of alcohol consumption with risk of incident atrial fibrillation has been inconsistent in previous, mainly case-control studies. Methods and Results-In a prospective cohort study, we studied the association between self-reported alcohol use and incident atrial fibrillation among 16 415 women and men enrolled in the Copenhagen City Heart Study. We ascertained use of beer, wine, and spirits individually at up to 3 study visits with a structured questionnaire. We identified cases of atrial fibrillation by routine study ECGs and a validated nationwide registry of all hospitalizations. A total of 1071 cases occurred during follow-up. Among both women and men, alcohol consumption throughout the moderate range was not associated with risk of atrial fibrillation. However, consumption of 35 or more drinks per week among men was associated with a hazard ratio of 1.45 (95% CI 1.02 to 2.04); few women consumed this amount of alcohol. Approximately 5% of cases of atrial fibrillation among men were attributable to heavy alcohol use. Further adjustment for blood pressure and incident coronary heart disease and congestive heart failure did not attenuate the association (hazard ratio 1.63; 95% CI 1.15 to 2.31). Conclusions-Heavy alcohol consumption is associated with a higher risk of atrial fibrillation, at least among men. This relationship does not appear to be related to the adverse effects of heavy drinking on coronary heart disease or blood pressure.

Major Bleeding Complications and Persistence With Oral Anticoagulation in Non‐Valvular Atrial Fibrillation: Contemporary Findings in Real‐Life Danish Patients

“…Our definition of major bleeding includes all episodes requiring hospitalization; and hospital databases have shown high precision for registration of bleeding events 27. The diagnostic coding for AF has previously been validated with high positive predictive value (97%) 28. Also, our analyses do not take local or regional recommendations or policies of first‐line OAC use into account.…”

When an enemy becomes a friend. On the benefits of alcohol consumption

“…В Копенгагенском иссле-довании злоупотребление алкоголем было достоверно ассоциировано с фибрилляцией предсердий в 5% случа-ев [27]. Анализируя накопленные к настоящему времени данные, Stephan et al приходят к выводу об отсутствии как проаритмогенного, так и антиаритмогенного эффекта малых доз алкоголя [28].…”

Alcohol in Prevention of Cardiovascular Pathology: Known and Unknown

“…Дискутируются гендерные особенности влияния частоты [13,20,22,23] и объема [13,23] употребления алкоголя на развитие ИБС. Так, Tolstrup J.…”

“…Лица, злоупотребляющие перио-дически ("binge drinking"), имеют склонность к воз-никновению единичных эпизодов ФП [22]. Это назы-вается "holiday heart syndrome" -"синдром празд-ничного сердца", описанный Ettinger H. O. в 1978г [29].…”

“…Это назы-вается "holiday heart syndrome" -"синдром празд-ничного сердца", описанный Ettinger H. O. в 1978г [29]. И, наконец, алкоголь может вызывать короткие, асимптомные эпизоды ФП с переходом в асимптом-ную постоянную форму [22].…”