When an enemy becomes a friend. On the benefits of alcohol consumption

Буеверов, А. О.; Богомолов, П. О.

doi:10.21518/2079-701x-2018-6-104-112

Cited by 3 publications

(2 citation statements)

References 84 publications

(91 reference statements)

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“…Однако если количество этанола, и особенно ацетальдегида, превышает базальный метаболизм печени, т. е. возможности ее ферментной системы трансформировать этанол в уксусную кислоту и воду, в кровь, помимо этанола, поступает ацетальдегид, который и вызывает тяжелые повреждения внутренних органов. При этом в крови больных нарастают изменения, которые отражают прогрессирующую патологию печени, в т. ч. регуляцию ею кроветворения [9]. Появляются различные отклонения в белковом, липидном, углеводном составах крови, ведущие к изменению ее реологии [11].…”

Section: Discussionunclassified

“…Анализируя пато-и морфогенез АБ, следует, однако, учитывать, что этанол -нормальный метаболит организма, он участвует в обмене липопротеинов и фосфолипидов, повышая уровень липопротеинов высокой и очень высокой плотности, регулирует обмен холестерина, а также участвует в синтезе клеточных и внутриклеточных мембран [9]. Для метаболизма этанола в печени существует ферментная система, которая в норме метаболизирует эндогенный этанол до уксусной кислоты и воды.…”

Section: Introductionunclassified

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Cardiac and vascular changes in the patho- and morphogenesis of alcohol use disorder

Кириллов

Ерохин

et al. 2020

Cardiovasc Ther Prev

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Aim. To reveal the patho- and morphogenesis of microvascular injury, cardiac and vascular changes in individuals with alcohol use disorder (AUD) and the role of cardiovascular pathology in the thanatogenesis of patients with chronic alcohol intoxication.Material and methods. The study was carried out using the data of 1118 autopsies of patients with AUD. We used histological, immunohistochemical, electron microscopic and biochemical methods, as well as morphometrics with statistical processing of the results.Results. Most patients with binge drinking developed alcoholic cardiomyopathy, cardiac hypertrophy, myocardial fatty degeneration, microvascular arteriolosclerosis and hyalinosis, diffuse focal sclerosis, as well as mitochondrial swelling and fragmentation of cristae in cardiomyocytes (CMC). The proportion of damaged CMC was 30,9±0,6%. Sclerosis affected 20,1±0,9% of the stroma. If alcohol was abandoned or consumed within the basal metabolic rate, these changes were reversible. With alcoholism, alcoholic cardiomyopathy, arteriosclerosis and arteriolosclerosis progressed. Compared with the binge drinking, the proportion of damaged CMC (44,8±1,1%) and the cardiosclerosis area (28,1±0,5%) significantly increased. Mallory bodies with autoantigen properties were detected. Morphological changes became irreversible.Conclusion. The data obtained identified the need for AUD isolation as an independent nosological entity with stage-by-stage pathogenesis. In the stage of binge drinking, the compensatory and adaptive capabilities of the body are preserved. With appropriate treatment, this stage of AUD is treatable. In the stage of alcoholism, changes in organs and tissues are irreversible, and it is more advisable for addiction medicine physicians to deal with palliative treatment of such patients.

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Section: Discussionunclassified

Section: Introductionunclassified

Cardiac and vascular changes in the patho- and morphogenesis of alcohol use disorder

Кириллов

Ерохин

et al. 2020

Cardiovasc Ther Prev

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Efficacy and Safety of a Fixed Combination of Glycyrrhizic Acid and Essential Phospholipids in Non-Alcoholic Fatty and Alcoholic Liver Disease: Results from Randomized Placebo-Controlled Trials

2021

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Background. Drug treatment of non-alcoholic fatty and alcoholic liver disease remains an urgent, unsolved problem. Due to the commonality of many pathogenetic mechanisms and predictors of progression, a universal approach to the search for a therapeutic agent can be considered. Aims pooled analysis of the results of two multicenter, randomized, double-blind, placebo-controlled studies of a fixed combination of glycyrrhizic acid and essential phospholipids in two dosage forms to study its efficacy and safety in non-alcoholic fatty and alcoholic liver disease, in the presence and absence of predictors of disease progression. Methods. The pooled analysis included 180 patients with non-alcoholic fatty liver disease (Gepard study) and 120 patients with alcoholic liver disease (Jaguar study). Patients of the main group received a fixed combination of 5.0 g intravenous jet 3 times a week for the first 2 weeks; then 2 capsules 3 times a day for the next 10 weeks. Patients in the control group received placebo according to the same scheme. The total duration of treatment was 12 weeks in the Gepard study (1 course of stepwise therapy) and 24 weeks in the Jaguar study (2 courses of stepwise therapy). A comparative analysis of the efficacy and safety of a fixed combination and a placebo was carried out, in the presence and absence of predictors of progression, separately for each nosology and in a mixed sample. Results. In patients with non-alcoholic fatty and alcoholic liver disease who received the fixed combination, in contrast to the placebo group, there was a statistically more significant decrease in the level of biochemical markers of inflammation alanine aminotransferase, aspartate aminotransferase, adiponectin, and the value of the AktiTest index. There was no negative trend in the NAFLD fibrosis score; more significant positive dynamics of FibroTest is shown. Predictors of disease progression hyperglycemia, hyperlipidemia, age did not have a negative impact on the results in the study group. The efficacy of the study drug was noted in patients with non-alcoholic fatty liver disease and normal body weight; data were obtained indicating its possible effectiveness with a high activity of the inflammatory process associated with alcoholic liver damage. The frequency of adverse events in the study and control groups was comparable. Conclusions. Based on a generalized analysis of the results of two studies, promising directions for the study and use of a fixed combination of glycyrrhizic acid and essential phospholipids were identified: non-alcoholic fatty liver disease without obesity, alcoholic steatohepatitis of high activity (as an adjuvant); steatohepatitis of non-alcoholic and alcoholic etiology, combined with hyperglycemia and hyperlipidemia.

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Analysis of Cardiovascular Diseases Risk Factors Distribution Among Male Population of the Republic of Crimea

Kryuchkova

Grigor'ev²,

Sukhareva

et al. 2022

Tavricheskiy Mediko-Biologicheskiy Vestnik

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According to the World Health Organization, cardiovascular diseases play a leading role in the structure of morbidity and mortality in the economically developed countries. It is known that 80% of the deaths of the working-age population are male. At the same time, gender differences in the occurrence of cardiovascular pathology began to be studied relatively recently. It should be noted that the largest population-based study on the identification of risk factors for cardiovascular disease among Russian citizens ESSE-RF (Epidemiology of Cardiovascular Diseases in the regions of the Russian Federation, 2012-2013) did not assess the prevalence of cardiovascular risk factors in Crimea.The aim of the study was to analyze the prevalence of cardiovascular risk factors among the male population of the Republic of Crimea. An online survey was conducted using a specially designed questionnaire to identify cardiovascular risk factors. The study interviewed 491 men living in the Republic of Crimea, aged 30-59 years, from November to December 2018.It was found that among the male population of the Republic of Crimea, both modifiable and non-modifiable risk factors for cardiovascular diseases are widespread. The most common cardiovascular risk factors were overweight and obesity (60.5%; 95% CI: 56.1; 64.8), physical inactivity (59.5%; 95% CI: 55.1; 63.8), smoking (53.2%; 95% CI: 48.7; 57.6) and unhealthy diet. In addition to traditional factors, it was found that new cardiovascular risk factors are also common among respondents.The study indicates that cardiovascular risk factors are widespread among the Crimean male population.

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When an enemy becomes a friend. On the benefits of alcohol consumption

Cited by 3 publications

References 84 publications

Cardiac and vascular changes in the patho- and morphogenesis of alcohol use disorder

Cardiac and vascular changes in the patho- and morphogenesis of alcohol use disorder

Efficacy and Safety of a Fixed Combination of Glycyrrhizic Acid and Essential Phospholipids in Non-Alcoholic Fatty and Alcoholic Liver Disease: Results from Randomized Placebo-Controlled Trials

Analysis of Cardiovascular Diseases Risk Factors Distribution Among Male Population of the Republic of Crimea

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