Albumin-based biomaterial for lung tissue engineering applications

Aiyelabegan, Hammed Tanimowo; Zaidi, Sadaf S. Z.; Fanuel, Songwe; Eatemadi, Ali; Ebadi, Malihe; Sadroddiny, Esmaeil

doi:10.1080/00914037.2016.1180610

Cited by 52 publications

(28 citation statements)

References 93 publications

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“…The use of BNP or NT-proBNP as a source of pharmacologic therapy in patients with chronic HF is associated with a significant decreased mortality rate especially in patients below 75 years of age as such there is a need for potent clinical novel therapeutic agents that optimally control HF, hypertension, and coronary artery disease. Any therapeutic strategy targeting the RAAS system and reducing its deleterious effects in HF pathogenesis and progression will optimally and majorly contribute to heart failure pharmacotherapy (39)(40)(41)(42)(43).…”

Section: Resultsmentioning

confidence: 99%

Untitled

2016

Cell Mol Biol

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Brain natriuretic peptide (BNP), also known as a B-type natriuretic peptide, is one of the important biomarkers with a proven role in the diagnosis of congestive heart failure (CHF). Researchers from the different clinical field have researched into the performance features of BNP testing in the acute care setup to assist and improve in diagnosing CHF and in predicting future morbidity and mortality rates. The potency of BNP has also been researched into in cases like myocardial ischemia and infarction, cor pulmonale, and acute pulmonary embolism (PE). Based on their vaso-dilatory and diuretic properties and ability to inhibit renin-angiotensin-aldosterone system, natriuretic peptides are able to provide an efficient technique and mechanism of action in the pathophysiologic framework for CHF treatment and management. Recent clinical studies reported that ularitide, a synthetic form of urodilatin, secreted by kidney may be effective in managing and treatment of decompensated heart failure. It has also been reported that Nesiritide, a recombinant natriuretic peptide has been proven to improve dyspnea and hemodynamic parameters in heart failure patients. This review provides an update on natriuretic peptides and their therapeutic potential in CHF treatment.

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Section: Resultsmentioning

confidence: 99%

Untitled

2016

Cell Mol Biol

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“…(1) Protein Scaffold: Albumin . Albumin is the most abundant serum protein in humans and has been shown to influence the attachment of cells to diverse scaffolds like collagen and fibronectin [ 246 ]. Albumin can comfortably serve as an interface between cells and scaffolds, hence enhancing the integration of one with the other.…”

Section: Pulmonary System and Diseasesmentioning

confidence: 99%

Section: Pulmonary System and Diseasesmentioning

confidence: 99%

“…The source of albumin is not only the serum but also egg white, milk, and a host of other plant and animal tissues [ 246 ]. However, the most commonly used albumin types for tissue engineering scaffold include (a) human serum albumin, (b) porcine serum albumin, and (c) bovine serum albumin [ 246 ]. Several techniques can be employed in the synthesis of albumin scaffold; these include freeze-drying methods, chemical/enzymatic cross-linking, solution evaporation, templating and leaching, and 3D printing, among others [ 251 – 253 ].…”

Section: Pulmonary System and Diseasesmentioning

confidence: 99%

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Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

Fakoya

Otohinoyi

Yusuf

2018

Stem Cells International

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The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncomplicated, the tissues that make up this system are undoubtedly complex. Hence, damage to this system is undesirable as its capacity to self-regenerate is quite limited. The surge in the incidence and prevalence of cardiopulmonary diseases has reached a critical state for a top-notch response as it currently tops the mortality table. Several therapies currently being utilized can only sustain chronically ailing patients for a short period while they are awaiting a possible transplant, which is also not devoid of complications. Regenerative therapeutic techniques now appear to be a potential approach to solve this conundrum posed by these poorly self-regenerating tissues. Stem cell therapy alone appears not to be sufficient to provide the desired tissue regeneration and hence the drive for biomaterials that can support its transplantation and translation, providing not only physical support to seeded cells but also chemical and physiological cues to the cells to facilitate tissue regeneration. The cardiac and pulmonary systems, although literarily seen as just being functionally and spatially cooperative, as shown by their diverse and dissimilar adult cellular and tissue composition has been proven to share some common embryological codevelopment. However, necessitating their consideration for separate review is the immense adult architectural difference in these systems. This review also looks at details on new biological and synthetic biomaterials, tissue engineering, nanotechnology, and organ decellularization for cardiopulmonary regenerative therapies.

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“…For instance, light sedation coupled with local or regional anesthesia [13,14], may not be appropriate for involved procedures. Drug-loaded nanoparticles provide an excellent solution for higher therapeutic efficacy, reducing drug toxicity and the increasing tropism [15][16][17][18][19][20][21][22][23]. Several nanocarriers are available, including nanoparticles, nanoliposomes, liposomes, micelles, solid lipid particles, quantum dots, surfactant vesicles, and different nanodevices [14,[24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%