Air Pollution and Immune Function

Tighe, Robert; Wheeler, Jennifer; Hollingsworth, John W.

doi:10.1007/978-1-4471-6669-6_11

Cited by 3 publications

(3 citation statements)

References 222 publications

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“…While another study reported significant association between outbreak of TB during dust storm episodes in China [27]. Inhalation of PM 10 could increase the risk of infection and impair defense mechanisms in the airways and lungs [28]. This pathophysiological impact of PM 10 causes alteration of macrophages and alveolar inflammation and thus permits bacterial proliferation [29] [30].…”

Section: Discussionmentioning

confidence: 99%

Ambient Air Pollution and Pulmonary Tuberculosis in Malaysia

Mutalip¹,

Hiong²,

Sarnat³

et al. 2018

Health

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Introduction: The possible impact of ambient air pollution exposure on the development of active tuberculosis (TB) remains obscure. This study investigated the potential role of ambient air pollution in activating pulmonary TB (PTB) compared to extrapulmonary TB (EPTB). Materials and Methods: Data on TB cases were obtained from national surveillance data in Malaysia during 2013 and air pollution data were obtained from 52 air-monitoring stations around the country for the 3-year period of 2011-2013. Analyses were performed to estimate the odds of PTB vs. EPTB with changes in the 3-year (2011-2013) average Air Pollutant Index (API) and specific ambient air pollutants. Results: Results showed that the 95th-percentile of API levels during 2011-2013 was moderate and it was not associated with PTB. However, the odds of active PTB compared to EPTB was significantly elevated with the 95th-percentile levels for particulate matter with an aerodynamic diameter of 10 μm or less (aOR = 1.006, 95% CI: 1.002, 1.011), p-value < 0.01, and sulfur dioxide (aOR = 1.012, 95% CI: 1.006, 1.019), p-value < 0.01. Conclusions: These results provide suggestive evidence of the effects of ambient air pollution on development of active pulmonary TB compared to extrapulmonary TB. Additional research on the impacts of ambient air pollution on TB is warranted.

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Section: Discussionmentioning

confidence: 99%

Ambient Air Pollution and Pulmonary Tuberculosis in Malaysia

Mutalip¹,

Hiong²,

Sarnat³

et al. 2018

Health

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“…High O3 levels have significant physiological effects on humans and other mammals (Lippmann 1989, U.S. EPA 2013, WHO 2013Fleming et al, 2018). Ozone exposure induces an oxidative stress at the respiratory tract that affects pulmonary function, bronchial airway reactivity or lung permeability, and depletes the antioxidant defences (Schelegle et al, 2009;Tighe et al, 2015;Brand et al, 2016). Epidemiological studies evaluating chronic long-term effects suggest that daily exposures to O3 increase mortality rates and respiratory morbidity of the European human populations (Jarret et al, 2009;Díaz et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological studies evaluating chronic long-term effects suggest that daily exposures to O3 increase mortality rates and respiratory morbidity of the European human populations (Jarret et al, 2009;Díaz et al, 2018). An important effect of O3 on mammalian physiology is related to the alteration of the immune system, and in particular of the function of alveolar macrophages, like decreased phagocytosis of particulate immune complexes, enhanced production of prostaglandin E2 or increased superoxide production (Hollingsworth et al, 2007;Tighe et al, 2015).…”

Section: Introductionmentioning

confidence: 99%