Emerging Insights into the Impact of Air Pollution on Immune-Mediated Asthma Pathogenesis

Tuazon, Jasmine; Kilburg-Basnyat, Brita; Oldfield, Lauren M.; Wiscovitch-Russo, Rosana; Dunigan-Russell, Katelyn; Fedulov, Alexey V.; Oestreich, Kenneth J; Gowdy, Kymberly M.

doi:10.1007/s11882-022-01034-1

Cited by 18 publications

(14 citation statements)

References 286 publications

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“…They make up to 90% of the cells in a ratio of 10:1. The microbiome’s composition is highly dynamic and dependent on host-associated factors such as age, diet, and environmental conditions [ 194 , 195 , 196 , 197 , 198 ] with the major phyla being Actinobacteria , Bacteroidetes , Firmicutes , and Proteobacteria . Diet, age, stress, antibiotics, xenobiotics, viruses, bacteria, parasites and diseases increase or decrease the relative abundance and diversity of bacterial species in the GI and other body sites.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

“…Diet, age, stress, antibiotics, xenobiotics, viruses, bacteria, parasites and diseases increase or decrease the relative abundance and diversity of bacterial species in the GI and other body sites. Alterations in GI tract bacterial levels or diversity (dysbiosis) can disrupt mucosal immunological tolerance, leading to allergic diseases including food allergy (FA) [ 195 , 199 ] and asthma and other infectious disorders [ 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 ]. Allergic diseases include heterogeneous inflammatory pathologies, such as respiratory and food allergies (FA), which are characterized by an immunological response with Th2 lymphocytes producing IL-4, IL-5, and IL-13 and low production of IFN-γ [ 195 , 199 ] and (Th9) producing IL-9 and IL-10 [ 196 ] as the main effector T cells.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

“…Allergic diseases include heterogeneous inflammatory pathologies, such as respiratory and food allergies (FA), which are characterized by an immunological response with Th2 lymphocytes producing IL-4, IL-5, and IL-13 and low production of IFN-γ [ 195 , 199 ] and (Th9) producing IL-9 and IL-10 [ 196 ] as the main effector T cells. They promote the induction of other effector cells involved in allergic inflammation, such as mast cells, basophils, and eosinophils [ 197 , 198 ]. According to reference [ 203 ], different levels of host-microbe interactions can be distinguished including: (1) microbe-gut epithelium interaction; (2) microbe-immune system interaction; (3) microbe-microbe interaction.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

“…Food contaminants entering the body through the oral route are directly exposed to the action of gut microflora, which play a considerable role in the metabolism of endogenous and exogenous substances in the diet, food digestion, xenobiotic metabolism and regulation of innate and adaptive immunological processes. Imbalance of gut bacteria composition could be important in the context of health or disease [ 195 , 196 , 197 , 198 , 199 , 200 , 201 ]. Thus, early-life exposure is critical for the microbiome development.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

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Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.

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Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

See 2 more Smart Citations

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

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“…The etiology underlying asthma includes both genetic predisposition and environmental exposures (2). In general, the airway inflammation in asthmatic setting arises from the reaction in response to allergens and/or other environmental factors, thereby leading to an aberrant airway Th2-type immune response (3). Although a great effort of studies had advanced the understanding of pathologic features of asthma, its mechanisms underlying the regulation of allergic airway inflammation are yet to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Regulatory T Cells, a Viable Target Against Airway Allergic Inflammatory Responses in Asthma

Zhang

Yuan²,

Chen³

et al. 2022

Front. Immunol.

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Asthma is a multifactorial disorder characterized by the airway chronic inflammation, hyper-responsiveness (AHR), remodeling, and reversible obstruction. Although asthma is known as a heterogeneous group of diseases with various clinical manifestations, recent studies suggest that more than half of the clinical cases are ‘‘T helper type 2 (Th2)-high’’ type, whose pathogenesis is driven by Th2 responses to an inhaled allergen from the environmental exposures. The intensity and duration of inflammatory responses to inhaled allergens largely depend on the balance between effector and regulatory cells, but many questions regarding the mechanisms by which the relative magnitudes of these opposing forces are remained unanswered. Regulatory T cells (Tregs), which comprise diverse subtypes with suppressive function, have long been attracted extensive attention owing to their capability to limit the development and progression of allergic diseases. In this review we seek to update the recent advances that support an essential role for Tregs in the induction of allergen tolerance and attenuation of asthma progression once allergic airway inflammation established. We also discuss the current concepts about Treg induction and Treg-expressed mediators relevant to controlling asthma, and the therapies designed based on these novel insights against asthma in clinical settings.

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Early-Life Exposure to Air Pollution and Childhood Asthma Cumulative Incidence in the ECHO CREW Consortium

Zanobetti,

Ryan,

Coull

et al. 2024

JAMA Netw Open

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ImportanceExposure to outdoor air pollution contributes to childhood asthma development, but many studies lack the geographic, racial and ethnic, and socioeconomic diversity to evaluate susceptibility by individual-level and community-level contextual factors.ObjectiveTo examine early life exposure to fine particulate matter (PM2.5) and nitrogen oxide (NO2) air pollution and asthma risk by early and middle childhood, and whether individual and community-level characteristics modify associations between air pollution exposure and asthma.Design, Setting, and ParticipantsThis cohort study included children enrolled in cohorts participating in the Children’s Respiratory and Environmental Workgroup consortium. The birth cohorts were located throughout the US, recruited between 1987 and 2007, and followed up through age 11 years. The survival analysis was adjusted for mother’s education, parental asthma, smoking during pregnancy, child’s race and ethnicity, sex, neighborhood characteristics, and cohort. Statistical analysis was performed from February 2022 to December 2023.ExposureEarly-life exposures to PM2.5 and NO2 according to participants’ birth address.Main Outcomes and MeasuresCaregiver report of physician-diagnosed asthma through early (age 4 years) and middle (age 11 years) childhood.ResultsAmong 5279 children included, 1659 (31.4%) were Black, 835 (15.8%) were Hispanic, 2555 (48.4%) where White, and 229 (4.3%) were other race or ethnicity; 2721 (51.5%) were male and 2596 (49.2%) were female; 1305 children (24.7%) had asthma by 11 years of age and 954 (18.1%) had asthma by 4 years of age. Mean values of pollutants over the first 3 years of life were associated with asthma incidence. A 1 IQR increase in NO2 (6.1 μg/m3) was associated with increased asthma incidence among children younger than 5 years (HR, 1.25 [95% CI, 1.03-1.52]) and children younger than 11 years (HR, 1.22 [95% CI, 1.04-1.44]). A 1 IQR increase in PM2.5 (3.4 μg/m3) was associated with increased asthma incidence among children younger than 5 years (HR, 1.31 [95% CI, 1.04-1.66]) and children younger than 11 years (OR, 1.23 [95% CI, 1.01-1.50]). Associations of PM2.5 or NO2 with asthma were increased when mothers had less than a high school diploma, among Black children, in communities with fewer child opportunities, and in census tracts with higher percentage Black population and population density; for example, there was a significantly higher association between PM2.5 and asthma incidence by younger than 5 years of age in Black children (HR, 1.60 [95% CI, 1.15-2.22]) compared with White children (HR, 1.17 [95% CI, 0.90-1.52]).Conclusions and RelevanceIn this cohort study, early life air pollution was associated with increased asthma incidence by early and middle childhood, with higher risk among minoritized families living in urban communities characterized by fewer opportunities and resources and multiple environmental coexposures. Reducing asthma risk in the US requires air pollution regulation and reduction combined with greater environmental, educational, and health equity at the community level.

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Emerging Insights into the Impact of Air Pollution on Immune-Mediated Asthma Pathogenesis

Cited by 18 publications

References 286 publications

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Regulatory T Cells, a Viable Target Against Airway Allergic Inflammatory Responses in Asthma

Early-Life Exposure to Air Pollution and Childhood Asthma Cumulative Incidence in the ECHO CREW Consortium

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