Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid

Abstract

The construction of organelle-targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle-targeting aggregation-induced emission photosensitizer TTPB and polydopamine nanomaterials. With the functional modification of TTPB, PTTPB can recognize sialic acid on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells can be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle-targeting imaging-guided can realize the tumor ablation with the synergistic effect of PDT and photothermal therapy.

New Degradable Semiconducting Polymers for Photoacoustic Imaging of λ-Carrageenan-Induced Arthritis Mouse Model

“…These results indicated that these nanosize particles had been prepared successfully. The sizes of the nanosize particles were suitable for biological applications as in the reported works. − …”

A biocompatible polyurethane fluorescent emulsion with aggregation-induced emission for targeted tumor imaging

“…Moreover, SA is unexpressed in normal cells, while is highly expressed on the surface of cancer cells like MCF-7 cells. 36 To further certificate the imaging and targeting ability of PTP for cancer cells, the fluorescent image for PTP in SA overexpressing cancerous cells (MCF-7 and HeLa cells) and normal cells (L929) were observed. As shown in Fig.…”

“…33,34 The introduction of functionalized ligands for active targeting can improve the selectivity and retention efficiency of nanoparticles at tumor sites compared to passively promoting drug accumulation within the tumor region. 35 It has been well documented that phenylboronic acid (PBA) can specifically recognize sialic acid (SA) on the cell surface and bind to the diol structure of SA to form reversible cyclic borates, 36 which help the material to be endocytosed by cells. Nowadays, studies have shown that the surface of some tumor cells such as breast, lung and bladder cancer cells have overexpressed sialic acid (SA) compared with those of normal cells.…”

Pentacene Nanorods as Effective Photosensitizer for Photodynamic Therapy of Tumor via Singlet Fission

“…PDT is a promising cancer-treatment modality owing to its minimally invasive nature, fewer side effects, cost-effectiveness, and friendliness to healthy tissue, which may help avoid the disadvantages of conventional modalities. [20][21][22][23][24][25][26][27] In PDT for treating cancers, after the administration of a tumor-localizing PS, the treated tumor is irradiated with light at a specific wavelength, for activating the PS. Subsequently, cancerous cells are locally killed by reactive oxygen species (ROS), especially by singlet oxygen ( 1 O 2 ) molecules that are generated by the PS.…”