New Degradable Semiconducting Polymers for Photoacoustic Imaging of λ-Carrageenan-Induced Arthritis Mouse Model

Abstract

Semiconducting polymer has a high extinction coefficient and a long band absorption and can be used as a photoacoustic imaging contrast agent. However, nonbiodegradable semiconducting polymers may cause biosafety issues due to being retained in the body. Therefore, developing degradable semiconducting polymers is necessary for in vivo imaging. Herein, we developed three degradable semiconducting polymers with unique optical properties. We adjusted the optical properties of semiconducting polymers by designing the molecular structure of semiconducting polymers. Polymers with a donor−π−acceptor structure could easily improve the optical properties through adjusting the donor or acceptor units. Through adjusting the electron-donor and -acceptor units, three diketopyrrolopyrrole derivative polymers (DPPTz, DPPQu, and DPPWu) were synthesized and converted into nanosize particles. By introducing the degradable chemical groups in the main chain structure of semiconducting polymers, diketopyrrolopyrrole polymers could be degraded by ClO − . Among these nanosize particles, DPPTz NPs and DPPQu NPs were used to achieve the in vivo photoacoustic imaging of λ-carrageenan-induced arthritis mouse model. This work provides a novel design idea for the designing of red-shifted semiconducting polymer with degradable properties.

Gold Polymer Nanomaterials: A Promising Approach for Enhanced Biomolecular Imaging

“…When combined with therapeutic agents, this platform holds significant potential as a robust theranostic tool. In another study ma et al prepared a biodegradable semiconducting polymer from diketopyrrolopyrrole with excellent photoacousitc imaging application in vivo for the λ-carrageenan-induced arthritis mouse model 88 . Polypyrrole based NPs were fabricated by Kesa et.…”

Degradable π-Conjugated Polymers

“…The example of photodegradation of p(BDT-TPD), a wellstudied donor−acceptor system, points toward the exploration of degrading other donor−acceptor systems, as the current trend leverages the use of donor−acceptor motifs to create high electronic performing π-conjugated polymers. Recently, Wang and co-workers 125 have synthesized a degradable donor−acceptor polymer featuring thiophene diketopyrrolopyrrole (TDPP) and benzothiadiazole (Tz) as the donor− acceptor units, respectively. Specifically, the thiophene in the backbone of p(TDPP-Tz) can be cleaved through oxidation via hypochlorite, leading to the overall degradation of the semiconducting polymer nanoparticles.…”

Prolonging Treatment Window of Photodynamic Therapy with Self‐Amplified H2O2‐Activated Photodynamic/Chemo Combination Therapeutic Nanomedicines

“…[25][26][27] An alternative strategy is to synthesize macromolecular PSs such as semiconducting polymers with long tumor retention time. [28][29][30] However, the 1 O 2 quantum yields of these PSs still hardly match small molecule PSs. [31,32] Thus, developing high-performance PSs with long tumor retention time is of great significance.…”