Age-specific prevalence of human papilloma virus infection among Nigerian women

Akarolo-Anthony, Sally; Famooto, Ayo; Dareng, Eileen; Olaniyan, Olayinka; Offiong, Richard; Wheeler, Cosette M.; Adebamowo, Clement

doi:10.1186/1471-2458-14-656

Cited by 60 publications

(62 citation statements)

References 29 publications

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“…Therefore, older women were less likely to have hr-HPV infection. Such inverse association with age has been shown in numerous other studies [37–39]. After adjusting for all the possible socio-demographic and reproductive confounders, women living with partners were less likely to be infected with HPV infection than compared to single women.…”

Section: Discussionsupporting

confidence: 75%

Prevalence of and Associated Risk Factors for High Risk Human Papillomavirus among Sexually Active Women, Swaziland

et al. 2017

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BackgroundHigh risk human papillomavirus (hr-HPV) infection and the dual burden of HIV remains a huge challenge in some low-income countries (LICs) such as Swaziland with limited or no data. We estimated the prevalence and investigated determinants of hr-HPV, including HIV infection among sexually active women in Swaziland.MethodsA total of 655 women aged between 15 and 49 years from five health facilities were randomly enrolled using a cross-sectional study design. Cervical cells were tested for hr-HPV types using GeneXpert HPV Assays.ResultsThe overall weighted hr-HPV prevalence was 46.2% (95%CI: 42.8–49.5). Of hr-HPV infected women, 12.4% (95%CI: 8.6–17.5) were HPV16-positive, 13.8% (95%CI:12.0–15.8) were positive for HPV18/45, 26.7% (95%CI: 24.2–29.3) for HPV31/33/35/52/58, 7.6% (95%CI: 7.6–11.9) for HPV51/59 and 11.0%, (95%CI: 7.9–15.3) for HPV39/56/66/68. Prevalence of hr-HPV decreased with increasing age. Overall HIV prevalence remained high (42.7%; 95%CI: 35.7–46.2). HIV infection was associated with hr-HPV infection (Adjusted OR = 4.9, 95%CI: 3.043–7.8, p<0.001). Overall hr-HPV/HIV co-infection was 24.4% (95%CI: 20.3–29.1) which was significantly higher among younger age groups (p<0.001). Prevalence of multiple group hr-HPV infection was significantly higher in HIV-positive versus -negative women (27.7% and 12.7% respectively, p<0.001). The presence, absence or unknown of history of STI with HIV did not appear to modify the relationship with hr-HPV (OR = 4.2, 95%CI: 2.6–7.1, OR = 4.6, 95%CI: 2.8–7.7, p<0.001, p<0.001 and OR = 4.1, 95%CI: 1.3–13.4, p<0.021 respectively).ConclusionThe prevalence of hr-HPV infection was high and significantly associated with HIV among sexually active women. Furthermore, the study has provided essential information about the HIV link with hr-HPV infections which may explain the high prevalence among HIV infected women. This can contribute to policy development and planning of prevention strategies incorporating HPV infection prevention especially among youth and HIV infected people.

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Section: Discussionsupporting

confidence: 75%

Prevalence of and Associated Risk Factors for High Risk Human Papillomavirus among Sexually Active Women, Swaziland

et al. 2017

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“…Not surprisingly for a sub-Saharan Africa country, our finding showed a high HPV prevalence (60 %). Indeed comparable rates were also reported in Equatorial Guinea (60 %) [ 15 ], in Conakry Guinea (51.5 %) [ 16 ], in Kenya (44.3 %) [ 17 ] and in Nigeria (37 %) [ 18 ]. A previous study conducted by Si-Mohammed et al [ 19 ] on women of childbearing age living in Libreville-Gabon reported the presence of HPV DNA in 46 % of cases.…”

Section: Discussionsupporting

confidence: 73%

Human papillomavirus genotypes distribution among Gabonese women with normal cytology and cervical abnormalities

Assoumou

Mbiguino

Mabika

et al. 2016

Infect Agents Cancer

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BackgroundCervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in this country. The aim of this study was to determine the HPV prevalence and distribution in a population of Gabonese women with normal cytology and cervical abnormalities.MethodsA total of 200 cervical samples collected in the “Departement d’Anatomie et de Cytologie Pathologiques” of the “Faculté de Medecine et des Sciences de la Santé” in Libreville, Gabonwere analyzed. Cytological status was classified according to Bethesda 2001. Nested polymerase chain reaction (PCR) using consensus degenerate PCR primers (MY09/11 and GP5+/6+) was performed for the detection of HPV DNA and HPV typing was done by DNA sequencing.ResultsCytological analysis showed that 87 % of women had normal cytology (n = 174/200). Among the 26 women with cytological abnormalities, predominance (61.5 %; 16/26) of low grade squamous intraepithelial lesion (LSIL) was found and no cervical cancer case was detected. Overall, HPV DNA was detected in 60 % of women (120/200). With respect to the cytological status, HPV DNA was found in 57.5 % of women with normal cervix and 76.9 % of women with abnormal cytology. HPV genotyping was performed on 114 HPV positive cases and revealed the presence of 11 distinct genotypes: 16, 18, 33, 31, 56, 6, 66, 70, 35, 45 and 81. The high risk type HPV 16 was the most common genotype found in all cytological categories. Six HPV positive samples could not be typed by DNA sequencing, probably due to multiple HPV infection. Evaluation of possible risk factors showed that HPV infection was related positively with number of sexual partners (≥3, OR = 2.3; 95 % CI, 1.3–4.3), history of sexually transmitted infection (Chlamydia, OR = 1.9; 95 % CI, 1.01–3.4) and marital status (single, OR = 2.0; 95 % CI, 1.1–3.5).ConclusionThe prevalence of HPV infection among Gabonese women is high. Our findings highlight the need to set up a national program to fight cervical cancer, combining Pap smear test and HPV testing, to improve cervical cancer prevention in Gabon.

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“…The patients with proved HPV infection had a significantly older age than those without HPV infection. These results are contrary to Girianelli et al [21] and Akarolo-Anthony et al [22] who observed a reduction in high-risk HPV prevalence with aging.…”

Section: Resultscontrasting

confidence: 99%

Is HPV virus associated with human breast cancer? Time to re-examine the postulate. Egyptian Study

Elsheshtawy

Shakweer²,

Elghamrini³

2017

APALM

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Background: There is increasing evidence that high-risk human papilloma virus (HPV) is involved in cancers in addition to cervical cancer. Infectious agents are thought to be responsible for approximately 16% of cancers worldwide, however there are mixed reports in the literature regarding the prevalence and potential pathogenicity of viruses in breast cancer. Methods:We screened 30 fresh frozen breast cancer tissue specimens collected immediately postoperative from patients in Ain-Shams University Hospital for the presence of human papilloma virus (HPV) DNA by PCR and Koilocytic changes in the breast cancer tissue. Results:Overall prevalence of HPV in malignant breast tissue was 16.7% In addition, we found that the oncogenic characteristics of HPV associated breast cancer are very similar to HPV-associated cervical cancer. Specifically, that putative koilocytes are present in some HPV associated breast cancers. Conclusion:The above observations indicate a likely causal role for high-risk HPV in human breast cancer and offer the possible role of HPV in breast cancer prognosis.

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Age-specific prevalence of human papilloma virus infection among Nigerian women

Cited by 60 publications

References 29 publications

Prevalence of and Associated Risk Factors for High Risk Human Papillomavirus among Sexually Active Women, Swaziland

Prevalence of and Associated Risk Factors for High Risk Human Papillomavirus among Sexually Active Women, Swaziland

Human papillomavirus genotypes distribution among Gabonese women with normal cytology and cervical abnormalities

Is HPV virus associated with human breast cancer? Time to re-examine the postulate. Egyptian Study

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