Age-related disappearance of Mayer-like heart rate waves

Jarisch, Wolfram; Jj, Ferguson; Shannon, Richard P.; Wei, Jeanne Y.; Goldberger, Ary L.

doi:10.1007/bf01945526

Cited by 26 publications

(11 citation statements)

References 17 publications

(1 reference statement)

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“…Similarly in middle-aged adults, arterial baroreflex activity was depressed during acute hypobaric hypoxia (Bernardi et al, 1998). The significance of such a mechanism in diminishing the heart rate response of the older adults in this study to hypoxic stress is challenged, however, by the noted blunting of the HRV response to orthostatic stress (Jarisch et al, 1987;Lipsitz et al, 1990;Pagani et al, 1986;Simpson and Wicks, 1988) and the purported decrease in the sensitivity of the baroreceptor reflex mechanism with advancing age (Pfeifer et al, 1983).…”

Section: Responses To Hypoxiamentioning

confidence: 59%

“…Frequency domain studies showing marked decreases in low-and high-frequency power, as well as total power, with age in lying (predominant parasympathetic control) and upright postures (sympathetic activation and parasympathetic withdrawal), suggest there is a decline of both parasympathetically and sympathetically mediated influences on HRV (Lipsitz et al, 1990;Schwartz et al, 1991;Shannon et al, 1987;Ziegler et al, 1992). Age-related differences have also been found in the HRV response to upright tilt (baroreceptor unloading and sympathetic stimulation), with young subjects exhibiting a much greater increase in total and low-frequency power than older subjects (Jarisch et al, 1987;Lipsitz et al, 1990;Pagani et al, 1986;Simpson and Wicks, 1988).…”

Section: Introductionmentioning

confidence: 96%

“…Spectral analysis studies of heart rate variability (HRV) have been consistent with a decline in cardiac autonomic control in healthy older adults (Jarisch et al, 1987). The power (amplitude) of high-frequency (HI, >0.15 Hz) oscillations in HRV, related to respiration, is known to reflect parasympathetic outflow to the heart, while low-frequency (LO, <0.15 Hz) power, related to baroreflex and vasomotor control, may be determined jointly by parasympathetic and sympathetic efferent cardiac activity (Pomeranz et al, 1985;Saul et al, 1989).…”

Section: Introductionmentioning

confidence: 97%

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Blunted Cardiac Autonomic Responsiveness to Hypoxemic Stress in Healthy Older Adults

Lucy

Kowalchuk²,

Hughson³

et al. 2003

Can. J. Appl. Physiol.

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Supine resting cardiac dynamics and responses to steady-state hypoxemia were investigated in six healthy older (59-72 yrs) adults using coarse-graining spectral analysis of heart rate variability (HRV) and were compared to six young (22-29 yrs) adults studied previously (Lucy et al., 2000). End-tidal carbon dioxide pressure (PETCO2) was clamped at 1-2 mmHg above the usual resting value for 11 min of euoxia (PETO2 100 mmHg), followed by 22 min of hypoxia (PETO2 55 mmHg). During euoxia, vagally mediated harmonic and fractal power of HRV of older adults was minimal. Hypoxia induced an increase in ventilation, p < 0.01, and heart rate, p < 0.05. The heart rate increase (mean +/- SE) of 0.23 +/- 0.08 beats.min-1 per 1% decrease in arterial O2 saturation was 25% of that demonstrated previously by young subjects, p < 0.001. In older adults, HRV spectral power remained unchanged during hypoxia, providing further evidence of an age-related blunting of cardiac autonomic function.

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Section: Responses To Hypoxiamentioning

confidence: 59%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

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Blunted Cardiac Autonomic Responsiveness to Hypoxemic Stress in Healthy Older Adults

Lucy

Kowalchuk²,

Hughson³

et al. 2003

Can. J. Appl. Physiol.

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“…Changes occurring in HRV with age were first reported in the 1980s. [11][12][13] Researchers trying to understand differences in waveforms and their relationship to the ANS demonstrated that parasympathetic tonus significantly decreased with age. 14 The usefulness of HRV analysis became immediately evident, and standards for HRV measurement were published in 1996.…”

Section: Measurement Of the Autonomic Nervous Systemmentioning

confidence: 99%

Heart Rate Variability and Biological Age: Implications for Health and Gaming

Russoniello

Zhirnov

Pougatchev

et al. 2013

Cyberpsychology, Behavior, and Social Networking

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Accurate and inexpensive psychophysiological equipment and software are needed to measure and monitor the autonomic nervous system for gaming and therapeutic purposes. The purpose of this study was to determine whether heart rate variability (HRV) derived from photoplethesmography (PPG) technology was predictive of autonomic nervous system (ANS) aging or biological age. Second, we sought to determine which HRV variable was most predictive of ANS change and aging. To test our hypotheses, we first conducted a criterion related validity study by comparing parameters of a 5 minute resting HRV test obtained from electrocardiography (ECG), the current "gold standard," with PPG technologies, and found them to be significantly correlated (r≥0.92) on all parameters during a resting state. PPG was strongly correlated to ECG on all HRV parameters during a paced six breaths per minute deep breathing test (r≥0.98). Further analysis revealed that maximum variation of heart rate had the highest negative correlation (r=-0.67) with age. We conclude that PPG is comparable to ECG in accuracy, and maximum variation of heart rate derived from a paced breathing test can be considered a marker of biological aging. Therapeutic interventions and games designed to reduce dysfunction in the ANS can now be developed using accurate physiological data.

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“…These measurements were obtained from subjects with an age of 64 ± 9.12 years (mean ± SD) using a modified SVA measurement protocol involving only the largest vessels. Other studies have reported a decrease in activity with an increasing age ( Jarisch et al, 1987 ). This suggested that the variability between the multiple photographs could be higher for younger subjects.…”

Section: Introductionmentioning

confidence: 84%

Experimental Characterization and Correlation of Mayer Waves in Retinal Vessel Diameter and Arterial Blood Pressure

2018

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Retinal vessels show various biological temporal variations that can impact diagnosis using a static vessel analysis. In this study, Mayer waves in the retinal vessel diameter and arterial blood pressure (BP) signals were characterized, and the temporal correlation between these two modalities was investigated. The arterial and venous vessel diameters and arterial BP were recorded simultaneously on human subjects. The obtained vessel diameters showed vasomotion amplitudes over time. The vessel diameter and BP signals contained multiple signals in the frequency domain and varied over time. The signal characteristics were similar within the measurements. The BP and arterial and venous vessel diameters were correlated. The highest correlation values between the signals were observed for shifts of 1 or 0 periods. The spectrum and amplitudes of the Mayer waves showed a high variability. The Mayer waves in the retinal vessel diameters showed the same characteristics as those in the arterial BP. A temporal dependency between the oscillations in the arterial BP and retinal vessel diameters was shown.

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Age-related disappearance of Mayer-like heart rate waves

Cited by 26 publications

References 17 publications

Blunted Cardiac Autonomic Responsiveness to Hypoxemic Stress in Healthy Older Adults

Blunted Cardiac Autonomic Responsiveness to Hypoxemic Stress in Healthy Older Adults

Heart Rate Variability and Biological Age: Implications for Health and Gaming

Experimental Characterization and Correlation of Mayer Waves in Retinal Vessel Diameter and Arterial Blood Pressure

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