Experimental Characterization and Correlation of Mayer Waves in Retinal Vessel Diameter and Arterial Blood Pressure

Abstract

Retinal vessels show various biological temporal variations that can impact diagnosis using a static vessel analysis. In this study, Mayer waves in the retinal vessel diameter and arterial blood pressure (BP) signals were characterized, and the temporal correlation between these two modalities was investigated. The arterial and venous vessel diameters and arterial BP were recorded simultaneously on human subjects. The obtained vessel diameters showed vasomotion amplitudes over time. The vessel diameter and BP signals contained multiple signals in the frequency domain and varied over time. The signal characteristics were similar within the measurements. The BP and arterial and venous vessel diameters were correlated. The highest correlation values between the signals were observed for shifts of 1 or 0 periods. The spectrum and amplitudes of the Mayer waves showed a high variability. The Mayer waves in the retinal vessel diameters showed the same characteristics as those in the arterial BP. A temporal dependency between the oscillations in the arterial BP and retinal vessel diameters was shown.

RETRACTED: Mechanisms Contributing to the Generation of Mayer Waves

“…Authors would successively observe congruent oscillations occurring throughout units residing within sympathetic- and respiratory-related propriobulbar interneuronal microcircuit oscillators ( Montano et al, 1995 , 1996 ; Morris et al, 2010 ; Ott et al, 2011 ), sympathetic neural efferent discharge ( Cerutti et al, 1991a , b , 1994 ; Janssen et al, 1997 ), dynamic arterial pressure magnitude ( Andersson et al, 1950 ; Guyton et al, 1951 ; Guyton and Satterfield, 1952 ; Guyton and Harris, 1961 ; Cerutti et al, 1991a , b , 1994 ), peripheral arterial resistance ( Killip, 1962 ), blood flow ( Killip, 1962 ), and cardiac interval ( Cerutti et al, 1991a , b , 1994 ). Rieger et al (2018) would successively reveal coherence among oscillations of dynamic arterial pressure magnitude and retinal arteriolar and venular diameter at the Mayer wave spectral band in human subjects. Transcalvarial optical imaging of mouse cerebral blood flow identified successive Mayer wave and very low frequency spectral bands exhibiting central tendencies of 0.2 and 0.01 Hz, respectively ( Bumstead et al, 2017 ).…”

Effects of Resistance Exercise with or without Whey Protein Supplementation on Ocular Changes after a 21-Day Head-Down Bed Rest

“…Moreover, the impact of the hydrostatic effects on retinal vessel diameter should not be overlooked. It has been previously demonstrated in 15 young healthy subjects that Mayer waves led to significant variations in retinal vessel diameter [ 47 ]. Moreover, Louwies et al [ 48 ] showed that hydrostatic effect might impact on central retinal arteriolar equivalent during a 21-day hypoxic bed rest performed in 11 subjects.…”

Vascular origins of low-frequency oscillations in the cerebrospinal fluid signal in resting-state fMRI: Interpretation using photoplethysmography

“…An additional complication is that M waves overlap in frequency with vasomotion. M waves are driven by BP oscillations (Julien, 2006;Rieger et al, 2018), and are expected to be systemically synchronous. On the other hand, vasomotion is regionally specific and is defined as the oscillation in vascular tone, which may or may not be accompanied by changes in vascular diameter, but gives rise to flowmotion (Sassaroli et al, 2012), but is not necessarily associated with fluctuations in blood pressure.…”