Purpose
Preserflo MicroShunt is a minimally-invasive glaucoma drainage micro-tube used to shunt aqueous humor from the anterior chamber to the subtenon space. The safety of the procedure was considered satisfactory with a majority of minor side effects.
Observation
We describe the 5 year endothelial cell loss after Preserflo implantation in 2 primary open angle glaucoma patients. The case 1 presented a device-cornea touch after a backward migration of the device. The case 2 presented a modified aspect of the device compatible with an inflammatory reaction. Both cases were explanted.
Conclusion
As described in Ahmed glaucoma valve, Xen gel stent and Cypass, Preserflo MicroShunt can lead to endothelial cell loss in some cases. A long-term prospective study with pre and postoperative endothelial cell count and AS-OCT or UBM evaluation of the device positioning would be of great interest to assess the real impact of Preserflo MicroShunt and risk factors for endothelial cell loss.
Neuro-ophthalmological changes have been reported after prolonged exposure to microgravity; however, the pathophysiology remains unclear. The objectives of the present study were twofold: (1) to assess the neuro-ophthalmological impact of 21 days of head-down bed rest (HDBR) and (2) to determine the effects of resistance vibration exercise (RVE) alone or combined with nutritional supplementation (NeX). In this case, 12 healthy male subjects completed three interventions of a 21-day HDBR: a control condition without countermeasure (CON), a condition with resistance vibration exercise (RVE) comprising of squats, single leg heel and bilateral heel raises and a condition using also RVE associated with nutritional supplementation (NeX). Intraocular pressure (IOP) was assessed by applanation tonometry. Retinal nerve fiber layer thickness (RNFLT) was assessed with spectral-domain optical coherence tomography, before HDBR and between Day 2 and Day 4 after each session of HDBR. In CON condition, IOP was preserved; while in RVE and NeX conditions, IOP was increased. In CON condition, RNFLT was preserved after HDBR. RVE and NeX conditions did not have significant effects on RNFLT. This study showed that a 3-week HDBR did not induce significant ophthalmological changes. However, RVE induced an elevation in IOP after HDBR. Nutritional supplementation did not reduce or exacerbate the side effects of RVE.
PurposeNovel non‐contact, non‐invasive Vibration Tonometry using analysis of induced corneal vibrations and their correlation to GAT IOP was tested in a large multicenter clinical trial.Methods470 eyes in 236 volunteers from various ethnic origins at Paris area hospital eye clinic and Glaucoma Institute were studied. History, vibration tonometry measurements in triplicate GAT, NIDEK air puff IOP, refractometry, keratometry and non‐contact pachymetry. Algorithm discovery was performed by random draw splitting runs into a discovery sample and a separate validation sample performed 10 times separately in men and womenResultsIn 236 patients, 34.6% of eyes had glaucoma, 51% of which women. 1311/1772 (76%) vibration tonometry measurements were in correct position. Population aged 20–92 yo with 48.7% females with mean of 62.1(± 13.5) in women and 62.5 (± 12.7) in men. CCT mean was 531.2 μ (± 37.3) in women and 534.8 μ (± 38.5) in men. 207 patients AL mean was 23.29 mm (± 1.68) in women and 23.73 mm (± 1.68) in men. GAT IOP ranged from 5.3 to 34 mm Hg, mean was 15.2 mm Hg (± 3.1) in women and 15.2 (± 3.52) in men ‐No significant differences. No adverse events during or post trial. Algorithm for women yielded 98.6% of IOP mean within 5 mm Hg of mean GAT IOP and 86% within 3 mm Hg. For men 96.4% of IOP mean was within 5 mm Hg of mean GAT IOP and 84.2% within 3 mm Hg from GAT IOP mean. Using the mean of 2 closest measures was used .ConclusionsCurrent algorithm shows no influence of CCT on IOP. Gender Specific algorithm concurrs with previous publications of different corneal hysteresis (lower) in women. Vibration tonometry is a valuable method for measurement of IOP without contact with precision and reproducibility independently of CCT. It may be a valuable tool for IOP measurement in thin and surgical corneas.
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