Age-Dependent Variation in Cartilage Response to Somatomedin

Abstract

17 RABBIT AND RAT FETUSES. A. J o s t , M . G i l b e r t , and A. Kervran. L a b o r a t . P h y s i o l o g i e compar g e , U n i v e r s i t G P a r i s VI, 75005 PARIS, F r a n c e .Glycogen s t o r a g e i n t h e f e t a l l i v e r obeys a hormonal c o n t r o l ( J o s t , Harvey L e c t . %:201, 1 9 6 1 ) . I n r a b b i t s it i s p r e v e n t e d by decapitating t h e f e t u s b e f o r e day 25; 'it i s r e s t o r e d by g i v i n g a c o r t i c o s t e r o i d + pro-

Response of Chondrocytes Isolated From Human Foetal Cartilage to Plasma Somatomedin Activity

“…Thus, somatomedin has little effect on proteoglycan or DNA synthesis in foetal or mature rat or rabbit cartilage, but has a pronounced effect on cartilage obtained during the period of rapid postnatal growth (Heins, Garland & Daughaday, 1970;Beaton & Singh, 1975). In contrast, the stimulation of proteoglycan synthesis by somatomedin in cartilage from foetal pigs is significantly greater than in cartilage obtained from young animals (Phillips, Herington & Daughaday, 1974).…”

Goiter recurrence in patients submitted to thyroid-stimulating hormone suppression: Possible role of insulin-like growth factors and insulin-like growth factor–binding proteins

“…Among these, insulin-like growth factor-I (IGF-I) and IGF-II are better known for their amino-acidic structure, 8 biosynthesis, [9][10][11] and stimulating activity towards the multiplication of several cell populations. [12][13][14][15][16][17] As with the other growth factors, they circulate in biologic fluids bound to proteins (insulinlike growth factor-binding proteins [IGFBPs]), 6 of which are currently known.…”