Goiter recurrence in patients submitted to thyroid-stimulating hormone suppression: Possible role of insulin-like growth factors and insulin-like growth factor–binding proteins

Torre, Giancarlo; Barreca, Antonina; Borgonovo, Giacomo; Minuto, Michele; Ansaldo, Gianluca; Varaldo, Emanuela; Minuto, Francesco

doi:10.1067/msy.2000.100937

Cited by 36 publications

(32 citation statements)

References 21 publications

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“…The recurrence rate for patients with unilateral thyroidectomy has been reported to be between 1.5-34% in previous studies, although the definition of recurrence was not consistent [3,[10][11][12][13]. For example, Rios and colleagues defined recurrence as recurrent nodules on imaging, but not necessarily requiring reoperation [10].…”

Section: Discussionmentioning

confidence: 99%

“…Opponents of unilateral resection are concerned with the higher recurrence rates associated with this operation due to the presence of remaining thyroid tissue. Previous studies report a wide range of recurrence rates, from 1.5-34% [3,[10][11][12][13]. Given this risk, some surgeons prefer to perform a bilateral thyroidectomy in order to decrease the possibility of developing a recurrent goiter and, thus, avoid further surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

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Unilateral Thyroidectomy for the Treatment of Benign Multinodular Goiter

Bauer

Murray

Clark

et al. 2013

Journal of Surgical Research

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BACKGROUND-Benign multinodular goiter (MNG) is one of the most commonly treated thyroid disorders. While bilateral resection is the accepted surgical treatment for bilateral MNG, the appropriate surgical resection for unilateral MNG continues to be debated. Bilateral resection generally has lower recurrence rates but higher complication rates than unilateral resection. Therefore, the purpose of this study was to define the recurrence and complication rates of unilateral and bilateral resections in order to determine the appropriate intervention for patients with unilateral, benign MNG.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unilateral Thyroidectomy for the Treatment of Benign Multinodular Goiter

Bauer

Murray

Clark

et al. 2013

Journal of Surgical Research

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“…cAMP-Stimulation gebildet werden (21,97). Die intrathyreoidale Freisetzung von bFGF (basic fibroblastic growth factor), der Endothelzellen und Fibroblasten zur Zellteilung anregt, ist invers zur Iodkonzentration reguliert (21,36).…”

Section: Iod Greift Auf Vielen Ebenen In Das Regelwerk Von Second Mesunclassified

Vergleich der Wirksamkeit zweier verschieden dosierter Levothyroxin-Iodid-Kombinationen in der Therapie der euthyreoten diffusen Struma

Kreißl

Tiemann²,

Hänscheid³

et al. 2001

Dtsch med Wochenschr

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“…But the recurrences occur even if total thyroidectomy is performed, with subsequent therapy with L-thyroxine. Some thyroid cells which were left during the first operation are no longer subject to control within the classical hypothalamic-pituitary-thyroid axis and their growth depends on individual expression of goitrogenic insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) [22]. Nodules in recurrent goiters are mainly polyclonal, with a higher than usual growth potential accelerated by unknown factors, so the recurrence occurs not only from nodules left during the primary operation [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Histopathological evaluation of recurrent goiter.

Rudnicki

Agrawal²,

Jeleń³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:The recurrent goiter is the regrowth of thyroid tissue after thyroidectomy. An inadequate surgical removal of the thyroid gland, lack of substitution therapy and pathological stimulation of the thyroid growth can all promote the recurrence. The aim of this study was to find the connection between the histopathological findings during the first and second operation and the recurrence of goiter. The study group consisted of 29 women and 1 man. The mean time to recurrence was 15 years. The most frequent histopathological finding during the first and second operation was struma nodosa. According to our observations different histopathological findings were found in 63.4% cases after primary and secondary thyroidectomy. Some genetic investigations showed that nodules in recurrent goiters did not derive from nodules left during the first operation but from a group of cells which had high growth potential. Thus, not only the operation technique and substitution after operation are key factors of successful therapy of goiter, but also other factors which stimulate the re-growth of thyroid tissue.

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Goiter recurrence in patients submitted to thyroid-stimulating hormone suppression: Possible role of insulin-like growth factors and insulin-like growth factor–binding proteins

Cited by 36 publications

References 21 publications

Unilateral Thyroidectomy for the Treatment of Benign Multinodular Goiter

Unilateral Thyroidectomy for the Treatment of Benign Multinodular Goiter

Vergleich der Wirksamkeit zweier verschieden dosierter Levothyroxin-Iodid-Kombinationen in der Therapie der euthyreoten diffusen Struma

Histopathological evaluation of recurrent goiter.

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