Reports on an investigation into the future of the product management concept in the South African pharmaceutical market, using South Africa as a representative microcosm of other international markets. Presents the findings of a survey carried out among marketing personnel. Predicts that the product manager of 1990 will perform the following roles: information‐providing; co‐ordinating; and boundary spanning. Suggests further that such product managers will not exercise line authority over critical product decisions.
Somatomedin activity has been demonstrated in the cerebrospinal fluid (CSF) of 12 normal subjects and one patient with acromegaly. In all cases the concentration was lower in the CSF than in the corresponding serum, and a significant correlation was demonstrated between the somatomedin activity in the two body fluids (p smaller than 0.01).
Serum concentrations of somatomedin and immunoreactive insulin were measured during the hypoglycemic phase of 3 patients with tumor hypoglycemia. Normal amounts of somatomedin were detected in their fasting sera, but they may have been inappropriate (or associated with enhanced insulin-like activity) considering the degree of hypoglycemia. Fasting serum insulin levels were consistently depressed, and in two of the cases remained low even after an oral glucose load. Nevertheless, the blood glucose concentrations of these two patients fell to hypoglycemic levels again by 3 hours; the mechanism of this reactive hypoglycemia remains unclear.
17 RABBIT AND RAT FETUSES. A. J o s t , M . G i l b e r t , and A. Kervran. L a b o r a t . P h y s i o l o g i e compar g e , U n i v e r s i t G P a r i s VI, 75005 PARIS, F r a n c e .Glycogen s t o r a g e i n t h e f e t a l l i v e r obeys a hormonal c o n t r o l ( J o s t , Harvey L e c t . %:201, 1 9 6 1 ) . I n r a b b i t s it i s p r e v e n t e d by decapitating t h e f e t u s b e f o r e day 25; 'it i s r e s t o r e d by g i v i n g a c o r t i c o s t e r o i d + pro-
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