Afectación adenopática mediastínica por sarcoma de Ewing

Vázquez, Alberto Caballero; Flores, Paula García; Chilla, Ángela Herrera

doi:10.1016/j.arbres.2016.08.003

Cited by 2 publications

(3 citation statements)

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“…Metastatic disease involving lung, lymph nodes, and several organs has been described 12 , 48 , 49 ; however, primary ESFTs of breast, 50 - 52 lung, 53 - 55 intestine, 56 , 57 and brain 22 , 58 - 62 were rarely reported.…”

Section: Discussionmentioning

confidence: 99%

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Murthy

Challa

Raju

et al. 2020

Clin Med�Insights�Pathol

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Introduction: The diagnosis of Ewing sarcoma family of tumours (ESFT) is challenging, especially in adults and in extra-skeletal or visceral location. Several morphologic mimics with varied treatment options and prognosis confer diagnostic dilemmas. Application of ancillary diagnostic modalities in surgical pathology in clinical routine has enabled accurate diagnosis of ESFT in bone, soft tissues, and viscera. Aim: The study aims to assess the clinicopathological features including molecular test results of ESFT with emphasis on sex, age, and location, especially extra-skeletal soft tissue and visceral location. Material and Methods: Data of clinicopathological, molecular tests (wherever performed), diagnosis rendered in 302 ESFT over a decade from our centre were reviewed. Statistical comparison of skeletal and extra-skeletal tumours with reference to age and sex was done using SPSS package. The P value of <.05 was considered significant. Results: The cohort included 302 ESFTs with 49% skeletal and 51% extra-skeletal tumours. Thigh was most common site among skeletal tumours; chest wall, paraspinal location, and retroperitoneum among soft tissues (39.4%); and kidney, ovary, and cervix among visceral tumours (11.3%). Fluorescence in situ hybridisation for EWSR1 gene rearrangement was positive in 54 patients and reverse-transcriptase polymerase chain reaction in 19 patients. Predominance of male sex, younger age and location in extremities among skeletal tumours and lack of gender predilection, higher age and axial location in extra-skeletal tumours were noted, which were statistically significant. Molecular tests were performed more frequently in extra-skeletal tumours, especially in visceral tumours to establish the diagnosis. Conclusions: The study showed statistically significant differences in the age, sex, and location between skeletal and extra-skeletal ESFT. The increased percentage of extra-skeletal tumours especially in viscera was attributed to the increased awareness and availability of ancillary techniques.

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Section: Discussionmentioning

confidence: 99%

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Murthy

Challa

Raju

et al. 2020

Clin Med�Insights�Pathol

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“…Среди костных сарком по встречаемости саркома Юинга занимает вторую позицию после остеосаркомы, составляя 8,64 %. Пик заболеваемости приходится на возраст от 10 до 20 лет (до 90 %), с незначительным преобладанием среди мужчин, с преимущественной локализацией в длинных трубчатых костях и костях таза [1][2][3][4].…”

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“…Среди факторов прогноза саркомы Юинга чаще фигурируют расположение опухоли («центральная» локализация) и ее размер (≥8 см), экстраскелетная форма, неудаленная первичная опухоль, повышенный уровень лактатдегидрогеназы крови (>450 Ед/л), низкая степень терапевтического патоморфоза (≤10 % жизнеспособной ткани опухоли) [2][3][4][5]11]. Однако, по мнению ряда авторов, наиболее информативным прогностическим фактором является наличие метастазов [3,4,23]. Кроме того, большое значение придается локализации органамишени.…”

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Ewing Sarcoma: Features of Lymphogenous Metastasis and Prognostic Factors

Poletaeva

Табакаев

et al. 2019

Sib. onkol. ž.

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Background. Lymphogenous metastasis in Ewing sarcoma is a relatively rare and poorly studied event associated with aggressive clinical course and poor prognosis. Until now, no risk factors for lymphogenous metastasis in patients with Ewing sarcoma are reported.The purpose of the study was to evaluate tumor characteristics as predictors for lymphogenous metastasis and to create a mathematical model for assessing the risk of developing lymph node metastases in patients with Ewing sarcoma.Material and Methods. Clinical characteristics of the tumor were studied in 88 patients with Ewing sarcoma: in 8 patients with lymphogenous metastasis and in 80 patients having no lymphogenous metastasis. The primary tumor in all patients with lymphogenous metastasis was found to have an extraskeletal origin. Morphological and immunohistochemical characteristics of the tumor were studied in 31 patients with Ewing sarcoma: in 8 patients with lymphogenous metastasis and in 23 patients without lymphogenous metastasis.Results. Statistical analysis and comparative evaluation of the characteristics of the immunophenotype and histological pattern of the tumor in the two studied groups showed significant differences regarding several of them: the structure of nuclear crowding (fusion of nuclei), focal hemorrhages, nuclear normochromasia, and positive expression of cytokeratins by tumor cells. The above signs (except for nuclear normochromasia) were the basis for creating a mathematical model capable of predicting the risk of lymphogenous metastases in Ewing sarcoma.Conclusion. The revealed association with lymphogenous metastasis of cytokeratin expression can be considered as indirect confirmation of the pathogenetic significance of the mesenchymal-epithelial transition in the mechanism of lymphogenous metastasis.

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Afectación adenopática mediastínica por sarcoma de Ewing

Cited by 2 publications

References 5 publications

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Ewing Sarcoma: Features of Lymphogenous Metastasis and Prognostic Factors

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