2021
DOI: 10.3389/fendo.2021.772914
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Aerobic Physical Exercise Improves Exercise Tolerance and Fasting Glycemia Independent of Body Weight Change in Obese Females

Abstract: Obesity is associated with increased risk of several chronic diseases and the loss of disease-free years, which has increased the focus of much research for the discovery of therapy to combat it. Under healthy conditions, women tend to store more fat in subcutaneous deposits. However, this sexual dimorphism tends to be lost in the presence of comorbidities, such as type 2 diabetes mellitus (T2DM). Aerobic physical exercise (APE) has been applied in the management of obesity, however, is still necessary to bett… Show more

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Cited by 3 publications
(2 citation statements)
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“…Though aerobic exercise has been used in the management of obesity, it has little effect on the end stage of obesity. An 8-week aerobic exercise training program was conducted with 8-week-old leptin-deficient female mice and the results showed that exercise could decrease the ratio of the islet to the pancreas area and balance the glucose level, however, it could not attenuate the body weight gain at the later stage of obesity [ 18 ].…”
Section: Resultsmentioning
confidence: 99%
“…Though aerobic exercise has been used in the management of obesity, it has little effect on the end stage of obesity. An 8-week aerobic exercise training program was conducted with 8-week-old leptin-deficient female mice and the results showed that exercise could decrease the ratio of the islet to the pancreas area and balance the glucose level, however, it could not attenuate the body weight gain at the later stage of obesity [ 18 ].…”
Section: Resultsmentioning
confidence: 99%
“…They also showed that BW was negatively associated with serum ACE2 ( 47 ). In addition, Boschetti et al reported that aerobic physical training could inhibit obesity-associated insulin resistance via alterations in the skeletal muscle phenotype (oxidative independent one) via the regulation of the ACE2 axis in a mouse model ( 48 ). Therefore, exercise could change the muscular cells’ function via the regulation of ACE2 and prevent SARS-CoV-2 infection via downregulation of ACE2.…”
Section: Discussionmentioning
confidence: 99%