Effects of High-Intensity Interval Vs. Moderate-Intensity Continuous Training on Body Composition and Gene Expression of ACE2, NLRP3, and FNDC5 in Obese Adults: A Randomized Controlled Trial

Armannia, Fariba; Ghazalian, Farshad; Shadnoush, Mahdi; Keyvani, Hossein; Gholami, Mohammad Reza

doi:10.47176/mjiri.36.161

Cited by 2 publications

(1 citation statement)

References 63 publications

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“…Li et al found that implementation of aerobic exercise in hyperlipidemic ApoE -/- mice reduced the expression of NLRP3 inflammasome-mediated pyroptosis in the aorta compared to the sedentary group and wild-type controls [ 62 ]. In a clinical trial, different exercise regimens were effective in reducing NLRP3 gene expression, verifying the potentially important role of this intervention against atherosclerosis [ 63 ]. The reduction in NLRP3 inflammasome-related circulating cytokines with exercise was further established in a recently published systematic review and meta-analysis of 19 randomized clinical trials, with aerobic exercise being the most effective modality [ 64 ].…”

Section: Inflammasome Modulation: Therapeutic Perspectivesmentioning

confidence: 99%

Inflammasomes in Atherosclerosis—From Pathophysiology to Treatment

Theofilis,

Oikonomou,

Chasikidis

et al. 2023

Pharmaceuticals

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Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque accumulation, remains a significant global health challenge. In recent years, inflammasomes, the intracellular multiprotein complexes crucial for initiating innate immune responses, have emerged as key players in atherosclerosis pathophysiology. This review article aims to provide a comprehensive overview of the current understanding of inflammasome activation and its impact on atherosclerosis development and progression. We explore the intricate interplay between traditional cardiovascular risk factors and inflammasome activation, leading to the perpetuation of inflammatory cascades that drive plaque formation and instability. The review focuses on the molecular mechanisms underlying inflammasome activation, including the role of pattern recognition receptors and cytokines in this process. Moreover, we discuss the contribution of inflammasomes to endothelial dysfunction, foam cell formation, and vascular inflammation. Additionally, recent advances in therapeutic strategies targeting inflammasomes are examined, including pharmacological agents and potential immunomodulatory approaches. By collating and analyzing the current evidence, this review provides valuable insights into the potential of inflammasome-targeted therapies for atherosclerosis management and treatment. Understanding the pivotal role of inflammasomes in atherosclerosis pathophysiology offers promising prospects for developing effective and personalized therapeutic interventions that can mitigate the burden of this prevalent cardiovascular disorder and improve patient outcomes.

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Section: Inflammasome Modulation: Therapeutic Perspectivesmentioning

confidence: 99%

Inflammasomes in Atherosclerosis—From Pathophysiology to Treatment

Theofilis,

Oikonomou,

Chasikidis

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

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NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention

Ding,

Song,

Yang

et al. 2024

Front. Pharmacol.

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NOD-like receptor protein 3 (NLRP3) inflammasome is an intracellular sensing protein complex that possesses NACHT, leucine-rich repeat, and pyrin domain, playing a crucial role in innate immunity. Activation of the NLRP3 inflammasome leads to the production of pro-inflammatory cellular contents, such as interleukin (IL)-1β and IL-18, and induction of inflammatory cell death known as pyroptosis, thereby amplifying or sustaining inflammation. While a balanced inflammatory response is beneficial for resolving damage and promoting tissue healing, excessive activation of the NLRP3 inflammasome and pyroptosis can have harmful effects. The involvement of the NLRP3 inflammasome has been observed in various cardiovascular diseases (CVD). Indeed, the NLRP3 inflammasome and its associated pyroptosis are closely linked to key cardiovascular risk factors including hyperlipidemia, diabetes, hypertension, obesity, and hyperhomocysteinemia. Exercise compared with medicine is a highly effective measure for both preventing and treating CVD. Interestingly, emerging evidence suggests that exercise improves CVD and inhibits the activity of NLRP3 inflammasome and pyroptosis. In this review, the activation mechanisms of the NLRP3 inflammasome and its pathogenic role in CVD are critically discussed. Importantly, the purpose is to emphasize the crucial role of exercise in managing CVD by suppressing NLRP3 inflammasome activity and proposes it as the foundation for developing novel treatment strategies.

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Effects of High-Intensity Interval Vs. Moderate-Intensity Continuous Training on Body Composition and Gene Expression of ACE2, NLRP3, and FNDC5 in Obese Adults: A Randomized Controlled Trial

Cited by 2 publications

References 63 publications

Inflammasomes in Atherosclerosis—From Pathophysiology to Treatment

Inflammasomes in Atherosclerosis—From Pathophysiology to Treatment

NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention

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