Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences

Sampaio, Luís Rafael Leite; Filho, Fernando Sérgio Studart Leitão; Almeida, Jamily Cunha de; Diniz, Danilo dos Santos; Patrocínio, Cláudio Felipe Vasconcelos; Sousa, Caren Nádia Soares de; Patrocínio, Manoel Cláudio Azevedo; Macêdo, Danielle Silveira; Vasconcelos, Silvânia Maria Mendes

doi:10.1016/j.neuroscience.2018.01.008

Cited by 21 publications

(18 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As there is a strong relationship between oxidative imbalance and pathophysiology of schizophrenia and Eryt extract has shown neuroprotective effect in previous studies, we decided to study oxidative and nitric compounds in several brain areas, such as PFC, HC and ST, related to the neurobiology of this mental disorder in animals submitted to the KET model of schizophrenia and treated with different doses of the standardized leaf extract of Eryt.…”

Section: Discussionmentioning

confidence: 99%

“…The schizophrenia affects about 1% of the world's population and it is defined as a neuronal syndrome with chronic transgression and disabling characteristics . Its pathophysiology is evidenced by mechanisms that involve neural oxidative imbalance, and it also includes the imbalance of neurotransmitters, such as dopamine and glutamate, such imbalances compromise brain function, leading to cell death …”

Section: Introductionmentioning

confidence: 99%

“…Due to this, the treatment of patients with schizophrenia is performed with antipsychotics that act on this dysfunction, divided into two groups, typical and atypical . This one is also known as second‐generation antipsychotics, and it has been shown to be quite effective in treatment, since they reveal a decrease in adverse effects .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Dias

Almeida

Vasconcelos

et al. 2018

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

Objectives To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine‐induced schizophrenia model. Methods Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. At 14th day, 30 min after the last administration of KET, the open‐field and pre‐pulse inhibition (PPI) tests were performed. Then, the animals were sacrificed and the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected for the oxidative tests. Key findings Ketamine increased spontaneous locomotor activity and grooming. KET decreased the PPI, which was reversed by combining it with Eryt or olanzapine. KET decreased GSH concentration in PFC and ST this was reversed by Eryt. KET increased MDA concentration in PFC and HC this was reversed by Eryt. Eryt and Olanzapine reduced MDA concentration in ST when compared to KET group. Nitrite concentration was reduced by administration of KET in the PFC. Conclusions These results demonstrate that the standardized extract of E. velutina can prevent behavioural symptoms and oxidative stress induced by repeated doses of KET.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Dias

Almeida

Vasconcelos

et al. 2018

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The existance of an oxidative instability has been increasingly highlighted in pathophysiological process of schizophrenia. Thus, the use of antioxidant substances may have a powerful effect for schizophrenia treatment [22]. It has been announced that ALA inhibits the inflammatory and oxidative damage induced by myeloperoxidase which is found in high concentrations in the serum of schizophrenia patients.…”

Section: Introductionmentioning

confidence: 99%

“…It has been announced that ALA inhibits the inflammatory and oxidative damage induced by myeloperoxidase which is found in high concentrations in the serum of schizophrenia patients. Besides, except of inhibiting myeloperoxidase, it can promotes the regulation in gene expression and transcription of proinflammatory factors [22]. ALA can also reduce oxidative stress which has been responsible for the pathogenesis of main psychiatric disorders, such as schizophrenia, bipolar disorder and major depression.…”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Agent In Psychiatric And Neurological Diseases: Alpha Lipoic Acid

Çekici¹,

BakÃ„Â±rhan²

2018

Acta Psychopathol

View full text Add to dashboard Cite

Ascorbic acid supplementation attenuates schizophrenia‐like symptoms in an animal model induced by ketamine

Supp

Avila

Mastella

et al. 2020

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Schizophrenia is a chronic neuropsychiatric disorder with a poorly understood pathophysiology. The theories about the disorder are mainly about dysregulation in one or more systems of neurotransmitters, and the progression triggers the presence of inflammatory markers indicates the possibility that the disorder is initially an inflammatory disease. The objective was to evaluate the ascorbic acid supplementation in an animal model of schizophrenia, on behavioral parameters, and cytokines involved in inflammation IL‐1β, IL‐10. Wistar rats with 60 days of age were used which were supplemented with ascorbic acid at 0.1, 1, and 10 mg/kg or saline for 14 days via orogastric gavage. Subsequently, four groups were given ketamine (25 mg/kg) and four groups received intraperitoneal saline from the 9th‐15th day of the experiment. After 30 min of the last administration of ketamine/saline, and behavioral test, rats were killed by guillotine decapitation and the brain structures were carefully dissected for biochemical analysis. Results showed that ascorbic acid supplementation prevented motor sensory loss but nor alter other parameters evaluated. We concluded that ascorbic acid may be used as a therapeutic adjuvant in schizophrenia and may help to improve the schizophrenic patient's life quality.

show abstract

Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences

Cited by 21 publications

References 66 publications

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Potential Therapeutic Agent In Psychiatric And Neurological Diseases: Alpha Lipoic Acid

Ascorbic acid supplementation attenuates schizophrenia‐like symptoms in an animal model induced by ketamine

Contact Info

Product

Resources

About