Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Abstract

Objectives To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine‐induced schizophrenia model. Methods Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. At 14th day, 30 min after the last administration of KET, the open‐field and pre‐pulse inhibition (PPI) tests were performed. Then, the animals were sacrificed and the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected for the oxidative tests. Key findings Ketamine increased spontaneous locomotor activity and grooming. KET decreased the PPI, which was reversed by combining it with Eryt or olanzapine. KET decreased GSH concentration in PFC and ST this was reversed by Eryt. KET increased MDA concentration in PFC and HC this was reversed by Eryt. Eryt and Olanzapine reduced MDA concentration in ST when compared to KET group. Nitrite concentration was reduced by administration of KET in the PFC. Conclusions These results demonstrate that the standardized extract of E. velutina can prevent behavioural symptoms and oxidative stress induced by repeated doses of KET.

Influência das plantas do gênero Erythrina no sistema nervoso: Uma revisão integrativa

“…Adicionalmente, os extratos das espécies do gênero Erythrina, em doses mais baixas, não apresentam influência cognitiva (Dantas et al, 2004), enquanto estudos com doses mais elevadas (>2000 mg/kg) mostram ser uma dose letal mediana (DL50) (Rodrigues et al, 2017). Enquanto que a exposição de organismos vivos a doses repetidas do extrato de E. velutina pode prevenir sintomas comportamentais e estresse oxidativo (Dias et al, 2019). Nesse sentido, reforça a ideia que o consumo dessas plantas deve ser cauteloso e acompanhado por um profissional, isso para evitar o risco de intoxicação.…”

SALICYLIC ACID AS A SALINE STRESS ATTENUATOR IN THE PHYSIOLOGICAL QUALITY OF Erythrina velutina SEEDS

“…E. velutina seedlings are used in regeneration projects in degraded areas, as they have rapid growth and adaptive characteristics to the semiarid environment (Rodrigues et al, 2018). This plant is used in traditional medicine to treat psychotic disorders, due to the presence of alkaloids, terpenes and fl avonoids, promoting neuroprotective, anxiolytic, sedative, anticonvulsant, antinociceptive and antioxidant eff ects (Dias et al, 2019).…”