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RESUMOO objetivo deste estudo é descrever a avaliação pelo público-alvo de um aplicativo de celular construído para o ensino dos sinais vitais. Seguiramse metodologicamente os passos propostos por Galvis-Panqueva para o processo de construção e validação de tecnologias. E neste estudo está descrita a etapa de avaliação pelo usuário. Participaram 29 acadêmicos do curso de graduação de enfermagem, que responderam a um instrumento de avaliação do aplicativo quanto às características de estilo, motivação e conteúdo. Como resultado, é possível destacar que a maior parte avaliou o aplicativo como excelente para as três características avaliadas: estilo (21-25; 72,6%-86,2%); motivação (20-25; 69,0%-86,2%); e conteúdo (21-25; 72,4%-86,2%). No tocante à adesão ao uso do aplicativo, considera-se que a avaliação demonstrada nos resultados permite sugerir que os estudantes o utilizarão de forma rotineira, conforme suas necessidades, haja vista que ao considerar altos os valores de motivação, estilo e conteúdo, estará implícito um envolvimento emocional em acreditar que o recurso poderá ser útil para auxiliar na tomada de decisões. Assim, conclui-se que o aplicativo foi bem avaliado pelo grupo de estudantes de enfermagem. Desse modo, prevê-se que esse recurso será uma alternativa viável para o fortalecimento do processo de aprendizagem. Palavras-chave: Enfermagem; Tecnologia Educacional; Sinais Vitais. ABSTR ACT The objective of this study is to describe the evaluation by the target audience of a mobile application program built for the teaching of vital signs.The steps proposed by Galvis-Panqueva for the construction and validation of technologies were methodologically followed. The user evaluation phase is also described in this study. Twenty-nine undergraduate nursing students participated and answered to an application assessment tool evaluating style, motivation and content characteristics. As a result, most respondents evaluated the application as excellent for the three evaluated characteristics: style (21-25, 72.6%-86.2%); motivation (20-25, 69.0%-86.2%); and content (21-25, 72.4%-86.2%). Regarding adherence to the use of the application, the evaluation allows concluding that students will use it routinely according to their needs, considering that the high scores given to motivation, style and content evidence emotional involvement in believing that the resource may be useful in assisting decision-making. Thus, the application was well evaluated by the nursing students group. In this way, it is expected that this resource will be a viable alternative for the strengthening of the learning process.

Objectives To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine‐induced schizophrenia model. Methods Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. At 14th day, 30 min after the last administration of KET, the open‐field and pre‐pulse inhibition (PPI) tests were performed. Then, the animals were sacrificed and the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected for the oxidative tests. Key findings Ketamine increased spontaneous locomotor activity and grooming. KET decreased the PPI, which was reversed by combining it with Eryt or olanzapine. KET decreased GSH concentration in PFC and ST this was reversed by Eryt. KET increased MDA concentration in PFC and HC this was reversed by Eryt. Eryt and Olanzapine reduced MDA concentration in ST when compared to KET group. Nitrite concentration was reduced by administration of KET in the PFC. Conclusions These results demonstrate that the standardized extract of E. velutina can prevent behavioural symptoms and oxidative stress induced by repeated doses of KET.

with filgrastim/lenograstim (0.340, 0.316, 0.410 for TC, AC-T, FEC-D, respectively). PP with pegfilgrastim was cost-effective versus SP with pegfilgrastim across all chemotherapy schemes (ICERs per FN event avoided: € 7,472, € 18,017 and € 9,996 for TC, AC-T and FEC-D, respectively). SP with pegfilgrastim was cost-effective versus no prophylaxis. All other treatment strategies were excluded from the analysis via extended dominance or were dominated by a less expensive and more effective strategy. For instance, PP and SP with lipegfilgrastim was found to be dominated by PP and SP with pegfilgrastim.These results held for patients with stage II and III BC. ConClusions: Our analysis finds PP with pegfilgrastim to be a cost-effective option for chemotherapy-induced FN in patients with BC in Greece.

Anxiety disorders are the most prevalent psychiatric disorders being also a comorbid state of other diseases. We aimed to evaluate the anxiolytic-like effects of carvedilol (CVD), a drug used to treat high blood pressure and heart failure with potent antioxidant effects, in animals exposed to chronic unpredictable stress (CUS). To do this, female Swiss mice were exposed to different stressors for 21 days. Between days 15 and 21, the animals received oral CVD (5 or 10 mg/kg) or the antidepressant desvenlafaxine (DVS 10 mg/kg). On the 22nd day, behavioral tests were conducted to evaluate locomotor activity (open field) and anxiety-like alterations (elevated plus-maze—EPM and hole board—HB tests). After behavioral determinations, the animals were euthanized, and the adrenal gland, blood and brain areas, prefrontal cortex (PFC), and hippocampus were removed for biochemical analysis. CUS reduced the crossings while increased rearing and grooming, an effect reversed by both doses of CVD and DVS. CUS decreased the number of entries and permanence time in the open arms of the EPM, while all treatments reversed this effect. CUS reduced the number of head dips in the HB, an effect reversed by CVD. The CUS reduced weight gain, while only CVD5 reversed this effect. A reduction in the cortical layer size of the adrenal gland was observed in stressed animals, which CVD reversed. Increased myeloperoxidase activity (MPO) and interferon-γ (IFN-γ), as well as reduction of interleukin-4 (IL-4) induced by CUS, were reversed by CVD. DVS and CVD increased IL-6 in both brain areas. In the hippocampus, DVS caused an increase in IFN-γ. Our data show that CVD presents an anxiolytic effect partially associated with immune-inflammatory mechanism regulation.

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