Potential Therapeutic Agent In Psychiatric And Neurological Diseases: Alpha Lipoic Acid

Çekici, e; BakÃ„Â±rhan, Yunus Emre

doi:10.4172/2469-6676.100165

Cited by 3 publications

(4 citation statements)

References 16 publications

(18 reference statements)

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“…23,49 As well as, supplementation of exogenous antioxidants including ALA has been found to modulate the oxidative stress and prevent or reverse the brain injury in different experimental models in which ROS are involved. 16,50,51 The results of the current study revealed that pre-conditioning LD gamma radiation or ALA supplementation after head irradiation or both treatments have significantly increased GSH content and TAC and reduced the levels of MDA and NO (Figures 1 and 2) in the brain as compared to corresponding values of HD head irradiated group. These results are in agreement with the previous study indicated that ALA could attenuate the oxidative stress-induced neural apoptosis following traumatic brain injury via activation of the Nrf2 signaling pathway and antioxidant enzymes and suppression of MDA production.…”

Section: Discussionmentioning

confidence: 50%

“…Previously, it was observed that LD whole-body irradiation (up to .5 Gy) stimulated the resistance of the cells to radicals’ toxicity and enhanced the endogenous antioxidants in rats exposed to liver, brain and heart toxicity. 23 – 49 As well as, supplementation of exogenous antioxidants including ALA has been found to modulate the oxidative stress and prevent or reverse the brain injury in different experimental models in which ROS are involved. 16 , 50 , 51 The results of the current study revealed that pre-conditioning LD gamma radiation or ALA supplementation after head irradiation or both treatments have significantly increased GSH content and TAC and reduced the levels of MDA and NO ( Figures 1 and 2 ) in the brain as compared to corresponding values of HD head irradiated group.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Low-Dose Gamma Radiation and Lipoic Acid on High- Radiation-Dose Induced Rat Brain Injuries

2021

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Aim This work aims to investigate the possible radio-adaptive mechanisms induced by low-dose (LD) whole-body γ-irradiation alone or combined with alpha-lipoic acid (ALA) administration in modulating high-dose (HD) head irradiation–induced brain injury in rats. Materials and Methods Rats were irradiated with LD (.25 Gy) 24 hours prior HD (20 Gy), and subjected to ALA (100 mg/kg/day) 5 minutes after HD and continued for 10 days. At the end of the experiment, animals were sacrificed and brain samples were dissected for biochemical and histopathological examinations. Results HD irradiation-induced brain injury as manifested by elevation of oxidative stress, DNA damage, apoptotic, and inflammatory markers in brain tissue. Histological examination of brain sections showed marked alterations. However, LD alone or combined with ALA ameliorated the changes induced by HD. Conclusion Under the present experimental conditions, LD whole-body irradiation exhibited neuroprotective activity against detrimental effects of a subsequent HD head irradiation. This effect might be due to the adaptive response induced by LD that activated the anti-oxidative, anti-apoptotic, and anti-inflammatory mechanisms in the affected animals making them able to cope with the subsequent high-dose exposure. However, the combined LD exposure and ALA supplementation produced a further modulating effect in the HD-irradiated rats.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Effect of Low-Dose Gamma Radiation and Lipoic Acid on High- Radiation-Dose Induced Rat Brain Injuries

2021

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“…We found significant improvement in the depressive symptoms of our patients, which is a finding supported by previous literature. A review study evaluating the potential of ALA administration in various psychiatric and neurological diseases and symptoms concluded that ALA is a promising adjuvant for treating depression as demonstrated by the hormonal fluctuations in the prefrontal cortex of mice models [28].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Alpha-Lipoic Acid on Diabetic Peripheral Neuropathy and the Upcoming Depressive Disorders of Type II Diabetics

Karalis¹,

Karalis²,

Karalis³

et al. 2021

Cureus

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“…Hence, the quest for better therapeutic options. Due mainly to its antioxidant properties, ALA has been reported to protect against oxidative injury in various disease processes, including neurodegenerative disorders (Calheiros et al, 2013;Çekici & Bakırhan, 2018;Silva et al, 2015;Uchida et al, 2015). In addition, several studies have shown the potential effect of ALA in improving insulin sensitivity (Liu et al, 2017b;Okanović et al, 2015;Salehi et al, 2019;Volchegorskiĭ et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Alpha-lipoic acid enhances short-term spatial memory of mice in open-space forced swim-induced depression mouse model

Yusha'u¹,

Adam²,

Wahab³

et al. 2021

Neurosci Res Notes

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Depression affects over 264 million people of all ages globally. Major depressive disorder significantly and chronically reduced quality of life by its association with functional impairment both at home and in the workplace. Depressive patients consistently complain about cognitive disturbances, significantly exacerbating the burden of this illness. Several studies have shown that alpha-lipoic acid (ALA) possesses mitochondrial, antioxidant, anti-inflammatory and anti-diabetic properties, indicating a basis for evaluating the efficacy of ALA in depression. Hence, this research aimed to assess the possible anti-depressant effect of ALA in mice exposed to the open space forced swim test (OSFST) model of depression. Twenty-five (25) Swiss albino mice were grouped into five groups (n=5). Group 1: [Normal saline (NS)], Groups 2, 3 and 4 received graded doses of ALA 100, 200 and 400 mg/kg, respectively, Group 5 received fluoxetine 20 mg/kg orally. The animals were subjected to OSFST, novel object recognition test (NORT) and Y-maze test. Serotonin, brain-derived neurotrophic factor (BDNF), superoxide dismutase (SOD), malondialdehyde (MDA) and catalase levels of the mice were assessed. Treatment with ALA and fluoxetine significantly decreased immobility time compared to NS group in OSFST (p<0.05). Also, ALA at doses of 200 & 400 mg/kg and fluoxetine 20 mg/kg significantly increased spontaneous alternation ratio in the Y-maze test compared to the normal saline group (p<0.05), however, no significant difference was observed in novel object recognition using NORT between NS, ALA and fluoxetine treated groups. Similarly, the level of serotonin, SOD and catalase were not altered between the ALA and fluoxetine treated groups and NS group. In contrast, fluoxetine 20 mg/kg increased the brain BDNF level of the mice (p<0.05). Alpha-lipoic acid ameliorated depression in the OSFST murine model of depression and improved their cognition. Thus ALA can be a promising candidate in the development of novel anti-depressant medication.

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Potential Therapeutic Agent In Psychiatric And Neurological Diseases: Alpha Lipoic Acid

Cited by 3 publications

References 16 publications

Effect of Low-Dose Gamma Radiation and Lipoic Acid on High- Radiation-Dose Induced Rat Brain Injuries

Effect of Low-Dose Gamma Radiation and Lipoic Acid on High- Radiation-Dose Induced Rat Brain Injuries

The Effect of Alpha-Lipoic Acid on Diabetic Peripheral Neuropathy and the Upcoming Depressive Disorders of Type II Diabetics

Alpha-lipoic acid enhances short-term spatial memory of mice in open-space forced swim-induced depression mouse model

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