Advances in organometallic/organic nanozymes and their applications

Zhang, Xiaojin; Lin, Shuo; Liu, Shuwen; Tan, Xin; Dai, Yu; Xia, Fan

doi:10.1016/j.ccr.2020.213652

Cited by 59 publications

(21 citation statements)

References 142 publications

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“…Substantial recent research efforts are directed in the recent years to develop artificial nanomaterials emulating the functions of native enzyme‐ “nanozymes.” [ 1–6 ] Inorganic metal oxides, [ 7–14 ] such as Fe 3 O 4 , V 2 O 5 , CeO 2 , MoO 3 , metal nanoparticles, such as Au, [ 15–17 ] Ag, [ 18,19 ] Pd, [ 20,21 ] or carbon based nanoparticles, such as carbon dots, [ 22 ] graphene quantum dots, [ 23 ] metal ions‐functionalized nanomaterial, [ 22 ] core‐shell inorganic nanomaterial composites, [ 24–28 ] for example, Fe 3 O 4 @C, Fe@BC, Cu@Pt, Au@CeO 2 , Au@Pt 4L , and inorganic cluster nanoparticles, such as Prussian Blue, [ 29,30 ] or hafnium metal‐oxo clusters [ 31 ] demonstrated enzyme‐like catalytic activities. Also, organic nanoparticles, for example, melanine, [ 32 ] polyethylenimine, [ 33 ] were introduced as functional catalytic systems of mimicking enzymes. Furthermore, metal‐organic framework nanoparticles (NMOFs) modified with metal ions‐ligand units [ 34–37 ] or catalytic nanoparticles [ 38–41 ] integrated in the porous structure of the frameworks were applied as catalytic nanozymes.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] Inorganic metal oxides, [7][8][9][10][11][12][13][14] such as Fe 3 O 4 , V 2 O 5 , CeO 2 , MoO 3 , metal nanoparticles, such as Au, [15][16][17] Ag, [18,19] Pd, [20,21] or carbon based nanoparticles, such as carbon dots, [22] graphene quantum dots, [23] metal ionsfunctionalized nanomaterial, [22] core-shell inorganic nanomaterial composites, [24][25][26][27][28] for example, Fe 3 O 4 @C, Fe@BC, Cu@Pt, Au@CeO 2 , Au@Pt 4L , and inorganic cluster nanoparticles, such as Prussian Blue, [29,30] or hafnium metal-oxo clusters [31] demonstrated enzyme-like catalytic activities. Also, organic nanoparticles, for example, melanine, [32] polyethylenimine, [33] were NMOFs yields an unprecedented OXD-mimicking catalyst that use oxygen as oxidant. In addition, the Au 3+ -functionalized NMOFs reveal POD activities and the resulting dual POD and OXD catalytic functions demonstrated by the Au 3+ -NMOFs can be cooperatively utilized, Scheme 1.…”

Section: Introductionmentioning

confidence: 99%

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Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions

Pan

Ouyang

Song

et al. 2022

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The synthesis and characterization of Au3+ -modified UiO-67 metal-organic framework nanoparticles, Au 3+ -NMOFs, are described. The Au 3+ -NMOFs reveal dual oxidase-like and peroxidase-like activities and act as an active catalyst for the catalyzed generation of O 2 •− under aerobic conditions or •OH in the presence of H 2 O 2 . The two reactive oxygen species (ROS) agents O 2 •− and •OH are cooperatively formed by Au 3+ -NMOFs under aerobic conditions, and in the presence of H 2 O 2. The Au 3+ -NMOFs are applied as an effective catalyst for the generation ROS agents for antibacterial and wound healing applications. Effective antibacterial cell death and inhibition of cell proliferation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacterial colonies are demonstrated in the presence of the Au 3+ -NMOFs. In addition, in vivo experiments demonstrate effective wound healing of mice wounds infected by S. aureus, treated by the Au 3+ -NMOFs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions

Pan

Ouyang

Song

et al. 2022

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“…Nanozymes are nanomaterials that possess unique physicochemical properties and mimic natural enzymes properties ( Figure 5 ) [ 87 ]. Significant progress has been made since the report of Zn 2+− triazacyclonane-functionalized gold nanoparticles with intrinsic peroxidase-like activity due to the rapid development of nanomaterials [ 88 ]. In addition, nanozymes offer high structural durability, stability, compatibility with biological materials, remarkable catalytic activity, and material variety.…”

Section: Nanozyme Biosensorsmentioning

confidence: 99%

Enzyme (Single and Multiple) and Nanozyme Biosensors: Recent Developments and Their Novel Applications in the Water-Food-Health Nexus

et al. 2021

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The use of sensors in critical areas for human development such as water, food, and health has increased in recent decades. When the sensor uses biological recognition, it is known as a biosensor. Nowadays, the development of biosensors has been increased due to the need for reliable, fast, and sensitive techniques for the detection of multiple analytes. In recent years, with the advancement in nanotechnology within biocatalysis, enzyme-based biosensors have been emerging as reliable, sensitive, and selectively tools. A wide variety of enzyme biosensors has been developed by detecting multiple analytes. In this way, together with technological advances in areas such as biotechnology and materials sciences, different modalities of biosensors have been developed, such as bi-enzymatic biosensors and nanozyme biosensors. Furthermore, the use of more than one enzyme within the same detection system leads to bi-enzymatic biosensors or multi-enzyme sensors. The development and synthesis of new materials with enzyme-like properties have been growing, giving rise to nanozymes, considered a promising tool in the biosensor field due to their multiple advantages. In this review, general views and a comparison describing the advantages and disadvantages of each enzyme-based biosensor modality, their possible trends and the principal reported applications will be presented.

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“…Artificial nanoenzymes are nanomaterials with enzymatic properties. Owing to their stability, small storage costs, and ease of synthesis on a large scale, artificial nanoenzymes have many advantages over natural enzymes [31][32][33]. Notably, certain types of nanoenzymes can mimic antioxidant systems in vivo, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione peroxidase (GPx) and efficiently scavenge harmful ROS and RNS to avoid the imbalance of oxidants and antioxidants [12,[34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

et al. 2022

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Exogenous antioxidant materials mimicking endogenous antioxidant systems are commonly used for the treatment of oxidative stress-induced injuries. Thus, artificial enzymes have emerged as promising candidates for balancing and treating the dysregulation of redox homeostasis in vivo. Herein, a one-pot hydrothermal strategy for the facile preparation of MoSe2-polyvinylpyrrolidone (PVP) nanoparticles (NPs) is reported. The synthesized NPs were biodegradable due to their exposure to oxygen and exhibited high stability. Moreover, they effectively mimicked various naturally occurring enzymes (including catalase, superoxide dismutase, peroxidase, and glutathione peroxidase) and scavenged free radicals, such as 3-ethylbenzothiazoline-6-sulfonic acid, ·OH, ·O2−, and 1,1-diphenyl-2-picrylhydrazyl radical. Further apoptosis detection studies revealed that MoSe2-PVP NPs significantly increased the cell survival probability in H2O2 in a concentration-dependent manner. The cytoprotective effect of MoSe2-PVP NPs was explored for an animal model of acute pancreatitis, which confirmed its remarkable therapeutic efficacy. Owing to the biodegradable and biocompatible nature of MoSe2-PVP NPs, the findings of this work can stimulate the development of other artificial nanoenzymes for antioxidant therapies. Graphical Abstract

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Advances in organometallic/organic nanozymes and their applications

Cited by 59 publications

References 142 publications

Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions

Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions

Enzyme (Single and Multiple) and Nanozyme Biosensors: Recent Developments and Their Novel Applications in the Water-Food-Health Nexus

Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

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Advances in organometallic/organic nanozymes and their applications

Cited by 59 publications

References 142 publications

Au3+‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O2•− and •OH Generating Nanozymes and Their Antibacterial Functions

Au3+‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O2•− and •OH Generating Nanozymes and Their Antibacterial Functions

Enzyme (Single and Multiple) and Nanozyme Biosensors: Recent Developments and Their Novel Applications in the Water-Food-Health Nexus

Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

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Resources

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Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions

Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions