Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions

Abstract

The synthesis and characterization of Au3+ -modified UiO-67 metal-organic framework nanoparticles, Au 3+ -NMOFs, are described. The Au 3+ -NMOFs reveal dual oxidase-like and peroxidase-like activities and act as an active catalyst for the catalyzed generation of O 2 •− under aerobic conditions or •OH in the presence of H 2 O 2 . The two reactive oxygen species (ROS) agents O 2 •− and •OH are cooperatively formed by Au 3+ -NMOFs under aerobic conditions, and in the presence of H 2 O 2. The Au 3+ -NMOFs are applied as an effective catalyst for the generation ROS agents for antibacterial and wound healing applications. Effective antibacterial cell death and inhibition of cell proliferation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacterial colonies are demonstrated in the presence of the Au 3+ -NMOFs. In addition, in vivo experiments demonstrate effective wound healing of mice wounds infected by S. aureus, treated by the Au 3+ -NMOFs.

Free radicals promote electrocatalytic nitrogen oxidation

“…2c further indicates the great catalytic performance of Co 3 O 4 . 45 From Fig. 2d , we can know that the Co 3 O 4 /H 2 O 2 mixture yield ˙OH was obtained by reacting with terephthalic acid (TA).…”

Beyond the fluorescence labelling of novel nitrogen-doped silicon quantum dots: the reducing agent and stabilizer for preparing hybrid nanoparticles and antibacterial applications

“…The high dosage of the H 2 O 2 might be harmful to the normal cells and delay the wound healing. 40–43 Thus, obviously, our N-SiQDs were merited with more advantages for the antibacterial application, such as low dosage of materials, without H 2 O 2 or external light or other stimulation, biocompatibility, easy fabrication, etc.…”

Nanosized metal–organic frameworks as unique platforms for bioapplications

“…That is the case of UiO-67-bipyridine, where the linker 2,2 0 -bipyridine-5,5 0 -dicarboxylic acid has in its structure two nitrogen atoms capable of coordinating redox metals, like Au for the generation of reactive oxygen species (ROS) or Pd 40 as a catalyst for Suzuki reactions. 41 Also with this methodology, it is possible to use the NMOF's channels as a template to create metallic nanowires. This concept was demonstrated by Duan et.…”