Advances in bone repair with nanobiomaterials: mini-review

Abstract

Nanotechnology has emerged to be one of the most powerful engineering approaches in the past half a century. Nanotechnology brought nanomaterials for biomedical use with diverse applications. In the present manuscript we summarize the recent progress in adopting nanobiomaterials for bone healing and repair approaches. We first discuss the use of nanophase surface modification in manipulating metals and ceramics for bone implantation, and then the use of polymers as nanofiber scaffolds in bone repair. Finally we briefly present the potential use of the nanoparticle delivery system as adjunct system in promoting bone regeneration following fracture.

Membranes for periodontal tissues regeneration

“…The nanomaterials have usually a larger surface to volume ratio, increased wettability, and protein adsorption when compared to conventional biomaterials. In addition, many nanobiomaterials have superior mechanical characteristics [74,75]. Moreover, the conjugation of nanobiomaterials with the traditional biomaterials used in tissue engineering, can provide better chemical and physical cues for cell adhesion and differentiation [76].…”

Advances in Bionanomaterials for Bone Tissue Engineering

“…2 87-94 Nanoparticle systems have also been studied as implant surface modifiers, as well as for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells, and biomimetic scaffolds useful for tissue cell cultures, transplantation, and clinical application. [95][96][97] In the following sections, we describe advances made in different bionanomaterials for bone tissue engineering. …”

Electrospun fibrous scaffolds combined with nanoscale hydroxyapatite induce osteogenic differentiation of human periodontal ligament cells

“…11,12 Therefore, nHA is more similar in morphology and crystal structure to the apatite found in natural bone or teeth than conventional regimens, and has better biological properties. 13 Our previous work has demonstrated that nHA had the ability to induce osteogenic differentiation of periodontal ligament cells (PDLCs) and may thus be a suitable tissue engineering scaffold for intrabony periodontal defects. 14 Following on from this finding, we undertook the present study, in which we embedded nHA in collagen fibers using electrospinning technology to mimic natural bone structure.…”