2014
DOI: 10.2147/ijn.s65272
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Electrospun fibrous scaffolds combined with nanoscale hydroxyapatite induce osteogenic differentiation of human periodontal ligament cells

Abstract: Periodontal repair is a complex process in which regeneration of alveolar bone is a vital component. The aim of this study was to develop a biodegradable scaffold with good biocompatibility and osteoinductive ability. Two types of composite fibrous scaffolds were produced by electrospinning, ie, type I collagen/poly(ε-caprolactone) (COL/PCL) and type I collagen/poly(ε-caprolactone)/nanoscale hydroxyapatite (COL/PCL/nHA) with an average fiber diameter of about 377 nm. After a simulated body fluid (SBF) immersio… Show more

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Cited by 39 publications
(22 citation statements)
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“…For example, interfering nanoparticles (iNOP-7), which use lysine dendrimers coupled to specific lipid chains, have been successfully used to downregulate apoB protein levels through the delivery of apoB siRNA into liver cells [ 96 , 97 ]. Additional adaptations of nanoparticle technology have focused on fine-tuning the specificity of miR delivery by using nanoparticle-aptamer modifications [ 98 ], as well as on/off approaches including pH-dependent miR release [ 99 ] and nanoparticle photo-activation [ 100 ] in order to induce localized miR delivery and thereby increase tissue specificity, limit toxicity, and reduce off-target effects.…”
Section: Strategies For Therapeutic Deliverymentioning
confidence: 99%
“…For example, interfering nanoparticles (iNOP-7), which use lysine dendrimers coupled to specific lipid chains, have been successfully used to downregulate apoB protein levels through the delivery of apoB siRNA into liver cells [ 96 , 97 ]. Additional adaptations of nanoparticle technology have focused on fine-tuning the specificity of miR delivery by using nanoparticle-aptamer modifications [ 98 ], as well as on/off approaches including pH-dependent miR release [ 99 ] and nanoparticle photo-activation [ 100 ] in order to induce localized miR delivery and thereby increase tissue specificity, limit toxicity, and reduce off-target effects.…”
Section: Strategies For Therapeutic Deliverymentioning
confidence: 99%
“… 100 , 101 , 103 , 104 , 106 , 107 , 120 Other technologies, including cell sheets, 3D printing, electrospinning and electrospray, were used in developing multiphasic scaffolds for periodontal regeneration. 100 , 101 , 103 , 104 , 106 , 107 , 120 In particular, bilayered poly (lactic‐ co ‐glycolic acid) (PLGA)/calcium phosphate constructs were applied in periodontal defects in beagle dogs. 107 A biphasic scaffold composed of a bone compartment (a fused deposition modelling scaffold) and a PDL compartment (an electrospun membrane combined with PDLSC sheet) were designed for simultaneous PDL and alveolar bone regeneration.…”
Section: Smart Biomaterials and Constructs To Promote Dental And Perimentioning
confidence: 99%
“…111 Scaffold processing techniques, such as co-electrospinning of HAp nanoparticles 112118 , have been used to produce composite membranes with improved strength and bioactivity. 119,120 Interestingly, a recent study combined electrospinning with melt-plotting to generate a hierarchical PCL/β-TCP scaffold embedded with collagen nanofibers. 121 Scanning electron micrographs of the constructs revealed uniform distribution of β-TCP particles in PCL struts and well-layered collagen nanofibers between composite struts.…”
Section: Advanced Biomaterials For Periodontal Regenerationmentioning
confidence: 99%