Membranes for periodontal tissues regeneration

Babo, Pedro S.; Pires, Ricardo Leandro; Reis, Rui L.; Gomes, Manuela E.

doi:10.1016/j.ctmat.2015.03.007

Cited by 8 publications

(3 citation statements)

References 90 publications

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“…ePTFE is chemically identical to PTFE and exhibits a porous microstructure that allows connective tissue ingrowth. ePTFE membranes for GTR have a typical bi-layered structure: the first layer, which is porous (90 vol %) and around 1-mm thick, can promote cell ingrowth, whereas the second layer (thickness 0.15 mm, porosity 30 vol %) acts as a space provider for regeneration, inhibiting the epithelial cell down-growth and giving structural stability [228,229]. Goretex ® membrane possesses an exceptional inertness as it does not elicit any foreign body reaction.…”

Section: Guided Tissue Regeneration (Gtr) Membranesmentioning

confidence: 99%

Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration

Iviglia

Kargozar

Baino

2019

JFB

137

114

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Periodontal diseases involve injuries to the supporting structures of the tooth and, if left untreated, can lead to the loss of the tooth. Regenerative periodontal therapies aim, ideally, at healing all the damaged periodontal tissues and represent a significant clinical and societal challenge for the current ageing population. This review provides a picture of the currently-used biomaterials for periodontal regeneration, including natural and synthetic polymers, bioceramics (e.g., calcium phosphates and bioactive glasses), and composites. Bioactive materials aim at promoting the regeneration of new healthy tissue. Polymers are often used as barrier materials in guided tissue regeneration strategies and are suitable both to exclude epithelial down-growth and to allow periodontal ligament and alveolar bone cells to repopulate the defect. The problems related to the barrier postoperative collapse can be solved by using a combination of polymeric membranes and grafting materials. Advantages and drawbacks associated with the incorporation of growth factors and nanomaterials in periodontal scaffolds are also discussed, along with the development of multifunctional and multilayer implants. Tissue-engineering strategies based on functionally-graded scaffolds are expected to play an ever-increasing role in the management of periodontal defects.

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Section: Guided Tissue Regeneration (Gtr) Membranesmentioning

confidence: 99%

Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration

Iviglia

Kargozar

Baino

2019

JFB

137

114

View full text Add to dashboard Cite

show abstract

“…The other side acts as a space provider to inhibit epithelial cell downgrowth. Several randomized clinical trials showed interesting results after three months of healing in periodontal regeneration [61][62][63][64][65][66]. Others reported several complications (exposure, suppuration, pain) probably related to the flap handling and suture collapsing [65].…”

Section: Non-resorbable Barriersmentioning

confidence: 99%

Biomaterials for Periodontal and Peri-Implant Regeneration

et al. 2021

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Periodontal and peri-implant regeneration is the technique that aims to restore the damaged tissue around teeth and implants. They are surrounded by a different apparatus, and according to it, the regenerative procedure can differ for both sites. During the last century, several biomaterials and biological mediators were proposed to achieve a complete restoration of the damaged tissues with less invasiveness and a tailored approach. Based on relevant systematic reviews and articles searched on PubMed, Scopus, and Cochrane databases, data regarding different biomaterials were extracted and summarized. Bone grafts of different origin, membranes for guided tissue regeneration, growth factors, and stem cells are currently the foundation of the routinary clinical practice. Moreover, a tailored approach, according to the patient and specific to the involved tooth or implant, is mandatory to achieve a better result and a reduction in patient morbidity and discomfort. The aim of this review is to summarize clinical findings and future developments regarding grafts, membranes, molecules, and emerging therapies. In conclusion, tissue engineering is constantly evolving; moreover, a tailor-made approach for each patient is essential to obtain a reliable result and the combination of several biomaterials is the elective choice in several conditions.

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“…Owing to its inertness, biocompatibility, nonadhesiveness, mechanical strength and hydrophobicity, it has been accepted as gold standard for human and animal comparative studies. [15] Numerous clinical research have evidenced the benefits of ePTFE membranes when used alone [16] or in combination with bone substitutes [17,18] including gain in clinical attachment and horizontal and vertical bone fill.…”

Section: Guided Tissue Regeneration Using Non Resorbable Barriersmentioning

confidence: 99%