Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration

Iviglia, Giorgio; Kargozar, Saeid; Baino, Francesco

doi:10.3390/jfb10010003

Cited by 139 publications

(145 citation statements)

References 267 publications

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“…In order to promote periodontal repair after SRP -conservative therapy including the surgical debridement of the periodontal pathogenic microorganisms, mineralized deposits on the root surface, infected cementum as well as all the injured/necrotic tissue parts [25], adjunctive anti-inflammatory therapy is recommended.…”

Section: Resultsmentioning

confidence: 99%

Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease

Cristache¹,

Totu²,

Burlibașa³

et al. 2020

Rev. Chim.

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The aim of the present study was to assess the genotoxicity of three different antibacterial, antioxidant and anti-inflammatory mixtures: tetracycline (T) with metronidazole (MZ), melatonin (MEL) with hyaluronic acid (HA), and T+MZ+MEL+HA, in order to choose the best formulation to be used as topic treatment for periodontal disease. In vitro Micronucleus Test was performed (MTvit) according to Organization for Economic Cooperation and Development (OECD) 487 recommendations, in a blind mode, without knowing the composition of the powders evaluated. The highest cytotoxicity and incidence of MN was observed in T+MZ mixture and the mixed compounds T+MZ+MEL+HA, 1 mg/mL in the cell culture, registered the lowest incidence of micronuclei, meaning the lowest cytotoxicity, comparable to the negative control sample. Based on the present findings and previously published results, it can be concluded that the complex mixture T, MZ, MEL and HA showed excellent cytotoxicity profiles, with lower rate of chromosomal damage risk, and therefore, is recommended for safe use as topical treatment in periodontal disease.

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Section: Resultsmentioning

confidence: 99%

Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease

Cristache¹,

Totu²,

Burlibașa³

et al. 2020

Rev. Chim.

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“…Regarding the mechanical performance, the scaffold should possess adequate mechanical strength until full tissue formation is achieved. Moreover, and in order to guarantee its function, the scaffold should degrade at a rate that has to match the bone remodeling process, which in the case of an alveolar bone within 5–6 months has been considered optimal [ 8 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges

et al. 2020

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Reduced periodontal support, deriving from chronic inflammatory conditions, such as periodontitis, is one of the main causes of tooth loss. The use of dental implants for the replacement of missing teeth has attracted growing interest as a standard procedure in clinical practice. However, adequate bone volume and soft tissue augmentation at the site of the implant are important prerequisites for successful implant positioning as well as proper functional and aesthetic reconstruction of patients. Three-dimensional (3D) scaffolds have greatly contributed to solve most of the challenges that traditional solutions (i.e., autografts, allografts and xenografts) posed. Nevertheless, mimicking the complex architecture and functionality of the periodontal tissue represents still a great challenge. In this study, a porous poly(ε-caprolactone) (PCL) and Sr-doped nano hydroxyapatite (Sr-nHA) with a multi-layer structure was produced via a single-step additive manufacturing (AM) process, as a potential strategy for hard periodontal tissue regeneration. Physicochemical characterization was conducted in order to evaluate the overall scaffold architecture, topography, as well as porosity with respect to the original CAD model. Furthermore, compressive tests were performed to assess the mechanical properties of the resulting multi-layer structure. Finally, in vitro biological performance, in terms of biocompatibility and osteogenic potential, was evaluated by using human osteosarcoma cells. The manufacturing route used in this work revealed a highly versatile method to fabricate 3D multi-layer scaffolds with porosity levels as well as mechanical properties within the range of dentoalveolar bone tissue. Moreover, the single step process allowed the achievement of an excellent integrity among the different layers of the scaffold. In vitro tests suggested the promising role of the ceramic phase within the polymeric matrix towards bone mineralization processes. Overall, the results of this study demonstrate that the approach undertaken may serve as a platform for future advances in 3D multi-layer and patient-specific strategies that may better address complex periodontal tissue defects.

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“…Conventional therapeutic approaches have focused on eliminating inflammatory sources, preventing disease progression, and regenerating periodontia using osteoconductive or osteoinductive biopolymeric materials, which commonly contain bioactive signaling molecules [ 42 , 43 , 44 , 45 , 46 ]. However, periodontal tissue formations are extremely limited and unpredictable in terms of the regeneration process due to structural complications, hierarchical constructs with micron-scaled dimensions, and elaborate tissue integrations for a functioning restoration [ 3 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Kim

Park

2020

Molecules

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The mineralized tissues (alveolar bone and cementum) are the major components of periodontal tissues and play a critical role to anchor periodontal ligament (PDL) to tooth-root surfaces. The integrated multiple tissues could generate biological or physiological responses to transmitted biomechanical forces by mastication or occlusion. However, due to periodontitis or traumatic injuries, affect destruction or progressive damage of periodontal hard tissues including PDL could be affected and consequently lead to tooth loss. Conventional tissue engineering approaches have been developed to regenerate or repair periodontium but, engineered periodontal tissue formation is still challenging because there are still limitations to control spatial compartmentalization for individual tissues and provide optimal 3D constructs for tooth-supporting tissue regeneration and maturation. Here, we present the recently developed strategies to induce osteogenesis and cementogenesis by the fabrication of 3D architectures or the chemical modifications of biopolymeric materials. These techniques in tooth-supporting hard tissue engineering are highly promising to promote the periodontal regeneration and advance the interfacial tissue formation for tissue integrations of PDL fibrous connective tissue bundles (alveolar bone-to-PDL or PDL-to-cementum) for functioning restorations of the periodontal complex.

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Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration

Cited by 139 publications

References 267 publications

Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease

Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease

Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges

Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

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