Advanced Oxidation Protein Products in Aged with Dementia

Demirbilek, Melike Erol; Kılıç, Nedret; Kömürcü, Hatice Ferhan; Akın, Kadir Okhan

doi:10.3844/ajisp.2007.52.55

Cited by 7 publications

(3 citation statements)

References 25 publications

(31 reference statements)

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“…The content of AGE in NWS revealed significant negative correlation with the MMSE result, and hence, salivary AGE could be used in the diagnosis of dementia. It is also worth reminding that the diagnostic utility of AGE has been demonstrated in the diagnosis and monitoring of the progression of Alzheimer’s disease and diabetes, as well as renal, cardiovascular and pulmonary diseases [ 2 , 37 ]. Our study, however, included only patients with moderate dementia, so that it is still unknown whether changes in salivary AGE could reflect clinical progression of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that in 2016 nearly 50 million people worldwide suffered from dementia, most of whom were over 65 years old [ 1 ]. Dementia is a group of neurodegenerative diseases characterized by progressive cognitive impairment and behavioural changes [ 2 , 3 ]. According to the pathophysiology, there are five basic types of dementia: Alzheimer’s dementia (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD) and mixed dementias (MxD) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?

Choromańska

Klimiuk

Kostecka-Sochoń

et al. 2017

IJMS

112

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Oxidative stress plays a crucial role in dementia pathogenesis; however, its impact on salivary secretion and salivary qualities is still unknown. This study included 80 patients with moderate dementia and 80 healthy age- and sex-matched individuals. Salivary flow, antioxidants (salivary peroxidase, catalase, superoxide dismutase, uric acid and total antioxidant capacity), and oxidative damage products (advanced oxidation protein products, advanced glycation end products (AGE), 8-isoprostanes, 8-hydroxy-2’-deoxyguanosine and total oxidant status) were estimated in non-stimulated and stimulated saliva, as well as in plasma and erythrocytes. We show that in dementia patients the concentration/activity of major salivary antioxidants changes, and the level of oxidative damage to DNA, proteins and lipids is increased compared to healthy controls. Non-stimulated and stimulated salivary secretions were significantly reduced in dementia patients. The deterioration in mini mental state examination (MMSE) score correlated with salivary AGE levels, which when considered with receiver operating characteristic (ROC) analysis, suggests their potential role in the non-invasive diagnosis of dementia. In conclusion, dementia is associated with disturbed salivary redox homeostasis and impaired secretory function of the salivary glands. Salivary AGE may be useful in the diagnosis of dementia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?

Choromańska

Klimiuk

Kostecka-Sochoń

et al. 2017

IJMS

112

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“…Recently, we demonstrated in a clinical trial with healthy women that a daily dose of 1200 mg of dried cranberry juice over 8 weeks resulted in a statistically significant decrease in serum levels of advanced oxidation protein products (2). Advanced oxidation protein products (AOPP) are defined as a novel marker of oxidative damage and considered reliable for estimating the degree of oxidant-mediated protein damage (10). However, few recent studies have evaluated the effect of the long-term consumption of cranberry products on antioxidative status and metabolism in healthy mammals.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Effects of Three Commercial Cranberry Products on the Antioxidative Status in Rats: A Pilot Study

Palíková

Vostalová

Zdařilová

et al. 2010

J. Agric. Food Chem.

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Cranberry (Vaccinium macrocarpon Ait. Ericaceae) fruits and juice are widely used for their antiadherence and antioxidative properties. Little is known however about their effects on clinical chemistry markers after long-term consumption. This study was conducted to evaluate the effect of three commercial cranberry products, NUTRICRAN90S, HI-PAC 4.0, and PACRAN on the antioxidative status of rodents, divided into three experimental groups. The products were given as dietary admixtures (1500 mg of product/kg of stock feed) for 14 weeks to male Wistar rats (Groups 2-4) and a control Group 1 which received only stock feed. There were no significant cranberry treatment-related effects on oxidative stress parameters, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase, superoxide dismutase, total antioxidant capacity, thiobarbituric acid reactive substances, advanced oxidation protein products, total SH-groups, or any other measured clinical chemistry markers. Hematological parameters, body weight, and food consumption were also unaffected by intake of cranberries. Only liver glutathione reductase activity and glutathione levels were significantly lower in Group 4 than in Group 1. Plasma alkaline phosphatase alone was significantly decreased in Group 2. No gross pathology, effects on organ weights, or histopathology were observed. No genotoxicity was found, and total cytochrome P450 level in liver was unaffected in all groups. The levels of hippuric acid and several phenolic acids were significantly increased in plasma and urine in Groups 2-4. The concentration of anthocyanins was under the detection threshold. The dietary addition of cranberry powders for 14 weeks was well tolerated, but it did not improve the antioxidative status in rats.

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Potential effect of carnosine encapsulated niosomes in bovine serum albumin modifications

Moulahoum

Sanli

Timur

et al. 2019

International Journal of Biological Macromolecules

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Advanced Oxidation Protein Products in Aged with Dementia

Cited by 7 publications

References 25 publications

Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?

Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?

Long-Term Effects of Three Commercial Cranberry Products on the Antioxidative Status in Rats: A Pilot Study

Potential effect of carnosine encapsulated niosomes in bovine serum albumin modifications

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