Long-Term Effects of Three Commercial Cranberry Products on the Antioxidative Status in Rats: A Pilot Study

Palíková, Irena; Vostalová, Jitka; Zdařilová, Adéla; Svobodová, Alena Rajnochová; Kosina, Pavel; Večeřa, Rostislav; Stejskal, David; Proskova, Jitka; Hrbáč, Jan; Bednář, Petr; Maier, Vítězslav; Cernochová, D; Šimánek, Vilı́m; Ulrichová, Jitka

doi:10.1021/jf903710y

Cited by 26 publications

(18 citation statements)

References 27 publications

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“…Dried cranberry fruits appear to be a good source of phenolic compounds, especially phenolic acids [26], which has been confirmed in the present study. However, we have found large among-brands variation in the phenolics concentrations in dried cranberries (p < 0.0001 for all compounds tested) ( Table 3).…”

Section: Dried Cranberriessupporting

confidence: 87%

Biologically Active Compounds in Selected Organic and Conventionally Produced Dried Fruits

Średnicka-Tober

Kazimierczak

Ponder

et al. 2020

Foods

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A growing demand for organic foods is driven by consumers′ perception that they are more nutritious. However, while there is a number of scientific studies showing some superior qualities of organically grown fruit and vegetables, including, i.e., higher content of phenolics, some vitamins and antioxidant activity, scientific research looking into the quality of processed organic products is very limited. At the same time the consumption of processed, convenient foods, with a long shelf-life, is rapidly increasing all over the world. Among the processed fruit-based products, dried fruits are recognized by consumers as one of the best snacks, highly nutritious and containing a large amount of fibre. In the presented experiment, four types of organic and conventionally produced dried fruits were examined: Apricots, apple rings, cranberries, and prunes. The concentrations of polyphenols (in all products) and carotenoids (in apricots) were measured using high performance liquid chromatography (HPLC). The study confirms that dry fruits can be undoubtedly considered as a rich source of polyphenols, however, a large variation in the concentrations of these compounds among different brands of products was also pointed: 219.03 ± 3.90–296.96 ± 2.86 mg 100 g−1 in dried apricots, 95.24 ± 15.12–627.71 ± 48.64 mg 100 g−1 in dried apple rings, 14.64 ± 0.43–203.09 ± 7.96 mg 100 g−1 in dried cranberries, and 134.65 ± 12.27–422.44 ± 9.00 mg 100 g−1 in prunes. Carotenoids concentrations in dried apricots ranged from 2.72 ± 0.31 to 17.49 ± 0.17 µg g−1. Among the tested dried fruits, only in the case of apricots organic products were characterized by the higher contents of phenolics and carotenoids compared to the conventional brands. In the case of other products there was either no consistent significant production system effect, or the concentrations of the analyzed phenolic compounds were higher in conventional products.

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Section: Dried Cranberriessupporting

confidence: 87%

Biologically Active Compounds in Selected Organic and Conventionally Produced Dried Fruits

Średnicka-Tober

Kazimierczak

Ponder

et al. 2020

Foods

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“…We selected cranberry whole fruit powder in preference to cranberry extract for the present study. Our previous work had shown equivalent efficacy between CFP and two different cranberry extracts ( 27 ) . The daily dose of 1500 mg dried cranberries was based on our double-blind study in young women ( 18 ) .…”

Section: Discussionmentioning

confidence: 93%

The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms

et al. 2010

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Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the present study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg of the dried powdered cranberries per d for 6 months (cranberry group; n 21) or no cranberry treatment (control group; n 21). Physical examination, International Prostate Symptom Score, quality of life (QoL), five-item version of the International Index of Erectile Function (IIEF-5), basic clinical chemistry parameters, haematology, Se, testosterone, PSA (free and total), C-reactive protein (CRP), antioxidant status, transrectal ultrasound prostate volume, urinary flow rate, ultrasound-estimated post-void residual urine volume at baseline, and at 3 and 6 months, and urine ex vivo anti-adherence activity were determined in all subjects. In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study. There was no influence on blood testosterone or serum CRP levels. There was no statistically significant improvement in the control group. The results of the present trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level.Vaccinium macrocarpon: Cranberries: Urinary tract disorders: Prostatitis: Prostate-specific antigen Prostate diseases are a major health concern for the male population throughout the Western world. Benign prostatic hyperplasia (BHP) and chronic prostatitis (CP), two of the most common medical conditions affecting older men (aged over 40 years), are associated with lower urinary tract symptoms (LUTS) which can have a negative impact on the quality of life (QoL). LUTS are divided into irritative and obstructive symptoms. The former include frequency, urgency and nocturia. The latter consist of slow urine stream and incomplete bladder emptying. Recently, a significant association between the serum levels of C-reactive protein (CRP) and irritative LUTS in both men and women was found (1,2) . On the other hand, CRP levels were not significantly associated with obstructive LUTS, or prostate-specific antigen (PSA) levels (3) . Untreated BHP and CP can lead to a number of medical complications, such as acute urinary retention, gross haematuria, repeated urinary tract infections, obstructive uropathy and cystolithiasis. The current standard of preventive care for men at risk of BHP and/or CP is treatment with a-adrenergic receptor blockers, 5-a-reductase inhibitors or antibiotics (4)

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“…41 The CP (HI-PAC 4.0) used was reported to contain *6.6% phenolic acids, 2.2% flavonoids, 0.6% anthocyanidins, 38% sugars, and 4.1% dietary fiber. 11,42 Several components in CPs were previously reported to have antiobesity functions. First, quercetin, one flavonoid found in CP, was found to inhibit adipogenesis by activation of AMPK genes and downregulating the expression of C/EBPa and SREBP-1.…”

Section: Discussionmentioning

confidence: 99%

Cranberry Product Decreases Fat Accumulation inCaenorhabditis elegans

Sun

Yue

Shen

et al. 2016

Journal of Medicinal Food

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Cranberry phenolic compounds have been linked to many health benefits. A recent report suggested that cranberry bioactives inhibit adipogenesis in 3T3-L1 adipocytes. Thus, we investigated the effects and mechanisms of the cranberry product (CP) on lipid metabolism using the Caenorhabditis elegans (C. elegans) model. CP (0.016% and 0.08%) dose-dependently reduced overall fat accumulation in C. elegans (N2, wild type) by 43% and 74%, respectively, without affecting its pumping rates or locomotive activities. CP decreased fat accumulation in aak-2 (an ortholog of AMP-activated kinase a) and tub-1 (an ortholog of TUBBY) mutants significantly, but only minimal effects were observed in sbp-1 (an ortholog of sterol response element-binding protein-1) and nhr-49 (an ortholog of peroxisome proliferator-activated receptora) mutant strains. We further confirmed that CP downregulated sbp-1, cebp, and hosl-1 (an ortholog of hormone-sensitive lipase homolog) expression, while increasing the expression of nhr-49 in wild-type C. elegans. These results suggest that CP could effectively reduce fat accumulation in C. elegans dependent on sbp-1, cebp, and nhr-49, but not aak-2 and tub-1.

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Long-Term Effects of Three Commercial Cranberry Products on the Antioxidative Status in Rats: A Pilot Study

Cited by 26 publications

References 27 publications

Biologically Active Compounds in Selected Organic and Conventionally Produced Dried Fruits

Biologically Active Compounds in Selected Organic and Conventionally Produced Dried Fruits

The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms

Cranberry Product Decreases Fat Accumulation inCaenorhabditis elegans

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