Potential effect of carnosine encapsulated niosomes in bovine serum albumin modifications

Moulahoum, Hichem; Sanli, Serdar; Timur, Suna; Zihnioğlu, Figen

doi:10.1016/j.ijbiomac.2019.07.003

Cited by 19 publications

(10 citation statements)

References 73 publications

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“…By employing a rodent model of diet-induced obesity and metabolic syndrome, the authors demonstrated the ability of carnosinol to dose-dependently attenuate 4-hydroxynonenal adduct formation in liver and skeletal muscle, while simultaneously mitigating inflammation, dyslipidemia, insulin resistance, and steatohepatitis. As described by Grasso et al [ 136 ], alternative approaches to increase carnosine delivery and its bioavailability include the use of carnosine derivatives [ 137 , 138 , 139 ]; vesicular systems (nanoliposomes, niosomes, and polymerosomes) [ 140 , 141 , 142 , 143 ]; and nanoparticulate systems [ 144 , 145 , 146 , 147 ]. The currently “under-used” intranasal administration route might also represent an innovative approach, since it can purportedly bypass the BBB and first-pass metabolism [ 148 , 149 ]; the vasodilatory activity of carnosine [ 150 ] also makes this endogenous dipeptide an attractive candidate for this kind of delivery.…”

Section: In Vivo Preclinical Studies: Administration Route Dosage Tre...mentioning

confidence: 99%

Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper

Caruso

2022

Molecules

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Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide and an over-the-counter food supplement with a well-demonstrated multimodal mechanism of action that includes the detoxification of reactive oxygen and nitrogen species, the down-regulation of the production of pro-inflammatory mediators, the inhibition of aberrant protein formation, and the modulation of cells in the peripheral (macrophages) and brain (microglia) immune systems. Since its discovery more than 100 years ago, a plethora of in vivo preclinical studies have been carried out; however, there is still substantial heterogeneity regarding the route of administration, the dosage, the duration of the treatment, and the animal model selected, underlining the urgent need for “coordinated/aligned” preclinical studies laying the foundations for well-defined future clinical trials. The main aim of the present position paper is to critically and concisely consider these key points and open a discussion on the possible “alignment” for future studies, with the goal of validating the full therapeutic potential of this intriguing molecule.

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Section: In Vivo Preclinical Studies: Administration Route Dosage Tre...mentioning

confidence: 99%

Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper

Caruso

2022

Molecules

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“…As such, preventive approaches for minimizing the formation of nonenzymatic glycation is of great importance. Among the compounds with deglycation activity, peptides such as carnosine and its analogs are especially studied (Moulahoum et al., 2019). Targeting diabetic complications by the inhibition of nonenzymatic glycation at different levels such as Schiff base, advanced glycation end‐products (AGE), and protein aggregation is very important.…”

Section: Resultsmentioning

confidence: 99%

Bioactive peptides with multiple activities extracted from Barley ( Hordeum vulgare L.) grain protein hydrolysates: Biochemical analysis and computational identification

Tok

Moulahoum

Kocazorbaz

et al. 2020

J Food Process Preserv

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Plant‐derived bioactive peptides demonstrate great potential given their availability and cost‐effectiveness. In this study, barley (Hordeum vulgare L.) grain proteins were explored for bioactive peptides with potential health applications. Gross grain proteins were obtained through aqueous extraction, after which, trypsin hydrolysis was performed. The hydrolysis process provided high peptide yields reaching 11%. The peptide hydrolysates were evaluated for their antioxidant and metal chelating activities, DPP4 inhibition, deglycation, and antimicrobial activity. The obtained results demonstrated biological activity levels of great importance and comparable to reference molecules. To confirm the experimental results, barley grain protein sequences were simulated for hydrolysis and explored for potential bioactive peptides using the FeptideDB. Indeed, barley grain proteins contain a great diversity of bioactive peptides with various biological activities. The current data highlights the promising therapeutic application of barley‐derived bioactive peptides. Further molecular and sequencing approaches are necessary to identify and characterize these peptides. Practical applications Barley (Hordeum vulgare L.) grain proteins are widely used cereals for nutrition and beverages. Their availability and low‐cost make them good sources for functional food exploration. We have described the potential of bioactive peptides obtained from barley grain proteins that have various activities including DPP4 inhibitory, antioxidant, antimicrobial, metal chelating, and deglycation activities. This data supports the potential of these peptides in biomedicine applications as a treatment option or as food supplement. Hence, the described peptide sequences could be exploited and industrialized by artificial synthesis and be proposed as food supplements or included in protein mixes for athletes.

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“…Increased levels of AOPPs and AGEs are found in amyloid plaques in AD brains, 70 and modifications such as the formation of AGEs and AOPPs may contribute to protein aggregation and amyloid fibril formation, and subsequent cognitive impairment. 71,72 Notably, MR significantly decreased the level of the AD-related biomarker Aβ-40 in D-Gal-induced aging mice (Fig. 10).…”

Section: Food and Function Papermentioning

confidence: 89%

Dietary methionine restriction improves gut microbiota composition and prevents cognitive impairment ind-galactose-induced aging mice

Yang

et al. 2022

Food Funct.

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Potential effect of carnosine encapsulated niosomes in bovine serum albumin modifications

Cited by 19 publications

References 73 publications

Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper

Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper

Bioactive peptides with multiple activities extracted from Barley ( Hordeum vulgare L.) grain protein hydrolysates: Biochemical analysis and computational identification

Dietary methionine restriction improves gut microbiota composition and prevents cognitive impairment ind-galactose-induced aging mice

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