Adsorption, and controlled release of doxorubicin from cellulose acetate/polyurethane/multi-walled carbon nanotubes composite nanofibers

Abstract

The cellulose acetate (CA)/poly (ε-caprolactone diol)/poly (tetramethylene ether) glycol-polyurethane (PCL-Diol/PTMG-PU)/multi-walled carbon nanotubes (MWCNTs) composite nanofibers were prepared via two-nozzle electrospinning on both counter sides of the collector. The performance of synthesized composite nanofibers was investigated as an environmental application and anticancer delivery system for the adsorption/release of doxorubicin (DOX). The synergic effect of MWCNTs and DOX incorporated into the nanofibers was investigated against LNCaP prostate cancer cells. The status of MWCNTs and DOX in composite nanofibers was demonstrated by SEM, FTIR and UV-Vis determinations. The adsorption tests using nanofibrous adsorbent toward DOX sorption was evaluated under various DOX initial concentrations (100-2000 mgL-1 ), adsorption times (5-120 minutes), and pH values (pH:2-9). Due to the fitting of isotherm and kinetic data with Redlich-Peterson and pseudo-second order models, both chemisorption and surface adsorption of DOX molecules mechanisms have been predicted. The drug release from both nanofibers and MWCNTs-loaded nanofibers was compared. The better drug sustained release profiles verified in the presence of composite nanofibers. LNCaP prostate cancer and L929 normal cells were treated to investigate the cytotoxicity and compatibility of synthesized composite nanofibers. The apoptosis/necrosis of hybrid nanofibers and MWCNTs loaded-nanofibers was investigated. The obtained results demonstrated the synergic effects of MWCNTs and DOX loaded-nanofibers on the LNCaP prostate cancer cells death.

Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review

“…Biodegradable PU used in PU-DDSs production can be obtained via polyaddition [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ] or the polycondensation process [ 69 ]. IPDI, HDI, LDI, CDI, HMDI, and BDI were used as IC components in biodegradable PUs synthesis.…”

“…Composite biodegradable DDSs containing PUs were also obtained [ 49 , 56 , 62 , 68 , 74 ]. Obtained waterborne polyurethane (WPU) and chitosan (CS) composite membranes exhibited fine biodegradability, favorable cytocompatibility, and excellent blood compatibility.…”

“…Another important example of systems of this type of DDSs are the nanofibers from cellulose acetate/PU/carbon nanotubes. The obtained results demonstrated the high effects of DOX-loaded nanofibers on the death of LNCaP prostate cancer cells [ 56 ]. Farboudi and co-workers obtained a composite DDS (PCL/HDI/PNIPAAm grafted-chitosan core) containing two cytostatics—5-FU and PACL [ 62 ].…”

Nanofiber Carriers of Therapeutic Load: Current Trends

“…To improve drug release profiles, various strategies were developed. Recently, composite cellulose acetate(CA)/poly(ε-caprolactone diol)/poly(tetramethylene ether)glycol-polyurethane NFs with incorporated multi-walled carbon nanotubes (MWCNT) were used for Dox adsorption and were applied to prostate cancer cell treatment [ 95 ]. The addition of MWCNT to the NFs led to significantly improved sustained Dox release as well as cancer cell death when compared to NFs without nanotubes.…”

Fabrication of poly(ϵ‐caprolactone)/paclitaxel (core)/chitosan/zein/multi‐walled carbon nanotubes/doxorubicin (shell) nanofibers against MCF‐7 breast cancer

“…In another study, Awasthi et al 43 used from molybdenum disulfide nanosheets incorporated‐PCL/zein nanofibers toward bone regeneration. In previous studies, we investigated the performance of poly (lactic acid)/MWCNTs/Fe 3 O 4 , 44 poly (lactic acid)/ polyethylene glycol/MWCNTs 45 and cellulose acetate/polyurethane 46 composite nanofibers for leukemia, lung, and prostate cancer cells, respectively. However, there is no report on the co‐incorporation of MWCNTs and anticancer drugs into the core‐shell nanofibrous structure in vivo.…”