Fabrication of poly(ϵ‐caprolactone)/paclitaxel (core)/chitosan/zein/multi‐walled carbon nanotubes/doxorubicin (shell) nanofibers against <scp>MCF</scp>‐7 breast cancer

Bahmani, Ehsan; Dizaji, Babak Faraji; Talaei, Sam; Koushkbaghi, Shahnaz; Yazdani, Hamid Reza; Abadi, Parvaneh Ghaderi-Shekhi; Akrami, Mohammad; Shahrousvand, Mohsen; Sharifianjazi, Fariborz; Irani, Mohammad

doi:10.1002/pat.5931

Cited by 13 publications

(4 citation statements)

References 50 publications

(81 reference statements)

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“…Anirudhan et al [ 95 ] used zein as a shell to encapsulate mesoporous silica for preventing premature drug leakage and realizing sustained release. Bahmani et al [ 119 ] used zein-based multi-walled carbon nanotubes (MWCNTs) to prepared nanofibers, and DOX and PTX were loaded. These composite core–shell nanofibers showed the synergistic therapeutic effects of MWCNTs and anticancer drugs, which had a high biocompatibility, with 84% of MCF-7 cancer cells killed at a low dosage.…”

Section: The Challenges and Solutions Of Zein-based Nanocarriers For ...mentioning

confidence: 99%

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

et al. 2023

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Cancer has emerged as a leading cause of death worldwide. However, the pursuit of precise cancer therapy and high-efficiency delivery of antitumor drugs remains an enormous obstacle. The major challenge is the lack of a smart drug delivery system with the advantages of biodegradability, biocompatibility, stability, targeting and response release. Zein, a plant-based protein, possesses a unique self-assembly ability to encapsulate anticancer drugs directly or indirectly. Using zein as a nanotherapeutic pharmaceutic preparation can protect anticancer drugs from harsh environments, such as sunlight, stomach acid and pepsin. Moreover, the surface functionalization of zein is easily realized, which can endow it with targeting and stimulus-responsive release capacity. Hence, zein is an ideal nanocarrier for the precise delivery of anticancer drugs. Combined with our previous research experiences, we attempt to review the current state of the preparation of zein-based nanocarriers for anticancer drug delivery. The challenges, solutions and development trends of zein-based nanocarriers for precise cancer therapy are discussed. This review will provide a guideline for precise cancer therapy in the future.

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Section: The Challenges and Solutions Of Zein-based Nanocarriers For ...mentioning

confidence: 99%

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

et al. 2023

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“…Coaxial electrospinning has become increasingly popular in creating core‐sheath structures for various functional applications 26–32 . Hollow fibers, as a special core‐shell fibers with an empty core, are frequently generated using a combination of coaxial electrospinning and post‐treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Coaxial electrospinning has become increasingly popular in creating core‐sheath structures for various functional applications. 26 , 27 , 28 , 29 , 30 , 31 , 32 Hollow fibers, as a special core‐shell fibers with an empty core, are frequently generated using a combination of coaxial electrospinning and post‐treatment. However, the post‐treatment is not always required when appropriate shell and core polymer solutions are chosen, for example, PCL in CHCl 3 /DMF as shell and PEO/water as core.…”

Section: Introductionmentioning

confidence: 99%

Direct jet coaxial electrospinning of axon‐mimicking fibers for diffusion tensor imaging

Grech‐Sollars

Statton

et al. 2023

Polymers for Advanced Techs

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Hollow polymer microfibers with variable microstructural and hydrophilic properties were proposed as building elements to create axon‐mimicking phantoms for validation of diffusion tensor imaging (DTI). The axon‐mimicking microfibers were fabricated in a mm‐thick 3D anisotropic fiber strip, by direct jet coaxial electrospinning of PCL/polysiloxane‐based surfactant (PSi) mixture as shell and polyethylene oxide (PEO) as core. Hydrophilic PCL‐PSi fiber strips were first obtained by carefully selecting appropriate solvents for the core and appropriate fiber collector rotating and transverse speeds. The porous cross‐section and anisotropic orientation of axon‐mimicking fibers were then quantitatively evaluated using two ImageJ plugins—nearest distance (ND) and directionality based on their scanning electron microscopy (SEM) images. Third, axon‐mimicking phantom was constructed from PCL‐PSi fiber strips with variable porous‐section and fiber orientation and tested on a 3T clinical MR scanner. The relationship between DTI measurements (mean diffusivity [MD] and fractional anisotropy [FA]) of phantom samples and their pore size and fiber orientation was investigated. Two key microstructural parameters of axon‐mimicking phantoms including normalized pore distance and dispersion of fiber orientation could well interpret the variations in DTI measurements. Two PCL‐PSi phantom samples made from different regions of the same fiber strips were found to have similar MD and FA values, indicating that the direct jet coaxial electrospun fiber strips had consistent microstructure. More importantly, the MD and FA values of the developed axon‐mimicking phantoms were mostly in the biologically relevant range.

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“…Polak et al used GO, MWCNTs, and SWCNTs for modification of ceramic membranes for tetracycline removal from water. Results showed MWCNTs increased adsorption properties more than other modifier components[65]. Their adsorption properties is determined by factors like as purity, porosity, site density, functional groups, CNT type, and surface area[64, 66,67].Isari et al modified single-walled carbon nano-tube with N-Cu doped TiO 2 .…”

mentioning

confidence: 99%

Carbon-based composites for removal of pharmaceutical components from water

Bahadorikhalili

Sharifianjazi

Azimpour

et al. 2022

jcc

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Carbon-based materials. including carbon nanotubes, graphene, and activated carbon, are among the most effective materials for pharmaceutical components removal from water. Despite the severe effect of pharmaceutical micropollutants in the aquatic environments and the effectiveness of carbon-based composites for water treatment, only a few studies has reviewed carbon-based materials for the removal of pharmaceutical components.Carbon-based materials with special properties like tunable surface functions, abundant pore structure, and high specific surface are used in different water treatment mechanisms such as adsorption and advanced oxidation processes. Graphene, activated carbon, and carbon nanotubes have been widely studied for pharmaceutical components removal. Herein, we have introduced carbon-based materials and reviewed recent studies on their properties, application in water treatment, and possible mechanism for removal of pharmaceutical components from aquatic environments.

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Fabrication of poly(ϵ‐caprolactone)/paclitaxel (core)/chitosan/zein/multi‐walled carbon nanotubes/doxorubicin (shell) nanofibers against MCF‐7 breast cancer

Cited by 13 publications

References 50 publications

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

Direct jet coaxial electrospinning of axon‐mimicking fibers for diffusion tensor imaging

Carbon-based composites for removal of pharmaceutical components from water

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