Adjustable intraocular lens power technology

Ford, Joshua; Werner, Liliana; Mamalis, Nick

doi:10.1016/j.jcrs.2014.05.005

Cited by 59 publications

(56 citation statements)

References 39 publications

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“…Incorrect lens power, patient dissatisfaction, and IOL opacification are common reasons for IOL replacement . Despite advances in biometry and IOL calculations, Behndig et al showed in a large analysis of Swedish cataract surgical outcomes that only two thirds of eyes planned for emmetropia become emmetropic .…”

Section: Discussionmentioning

confidence: 99%

“…Almost 1% of cataract surgery patients will eventually require an intraocular lens (IOL) exchange . While IOL dislocation/decentration is the most common reason for IOL exchange, ranging between 37.3% and 46% of the cases, incorrect IOL power (23–41.2%), IOL opacification (7%) and patient dissatisfaction (21%) are other common causes . Furthermore, patient expectations are increasingly high, especially with increased use of premium IOLs .…”

Section: Introductionmentioning

confidence: 99%

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Optic replacement in a novel modular intraocular lens system

Guan

Kramer

MacLean

et al. 2016

Clinical Exper Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optic replacement in a novel modular intraocular lens system

Guan

Kramer

MacLean

et al. 2016

Clinical Exper Ophthalmology

Self Cite

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“…To avoid these postoperative problems, a potential alternative is the use of an adjustable IOL. Many mechanically and magnetically adjustable IOLs were patented or described in the literature . However, these lenses have some disadvantages such as invasive adjustment procedures and incompatibility with imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

“…In the last decades, several noninvasive adjustable IOLs have been reported in literature. Sacharoff et al and Bille have developed IOLs that are postoperatively adjustable by femtosecond laser . These IOLs consist of an optic containing thin layers of shape‐altering material, which change shape and cause the optic change after activation by femtosecond laser.…”

Section: Introductionmentioning

confidence: 99%

“…This technique was also used by Ding et al to modify the refractive index of silicon and 2‐hydroxyethyl methacrylate hydrogel . Calhoun Vision has developed a light‐adjustable IOL (LAL) based on photosensitive polymers or molecules . The formulation of LAL is based upon a silicone matrix containing a photoreactive macromer, photoinitiator, and UV absorbers.…”

Section: Introductionmentioning

confidence: 99%

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Photoreversibility and Biocompatibility of Polydimethylsiloxane‐Coumarin as Adjustable Intraocular Lens Material

Jellali

Bertrand

Alexandre

et al. 2017

Macromolecular Bioscience

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Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomedical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a photoreversible PDMS-coumarin network, whose shape and properties can be adjusted postoperatively in a noninvasive manner, is developed. The synthesis of PDMS-coumarin is achieved by amidation of a coumarin acid chloride derivative with amine-functionalized PDMSs. Under exposure of λ > 300 nm, these polymers can be cured by dimerization of coumarin. The cured polymers can be uncrosslinked via photocleavage of cyclobutane dimers upon illumination at λ < 290 nm. The diffusion of linear PDMSs in a crosslinked network and the controlled shape modification are studied, which demonstrate that these polymers are good candidates for adjustable IOL application. IOL disks prepared from these materials show high hydrophobicity and good transparency. In vitro cytotoxicity, lens epithelial cell adhesion assays, and rabbit host reaction against implanted disks demonstrate the biocompatibility of the polymer.

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In Situ Generated Medical Devices

Cohn

Sloutski

Elyashiv

et al. 2019

Adv Healthcare Materials

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Medical devices play a major role in all areas of modern medicine, largely contributing to the success of clinical procedures and to the health of patients worldwide. They span from simple commodity products such as gauzes and catheters, to highly advanced implants, e.g., heart valves and vascular grafts. In situ generated devices are an important family of devices that are formed at their site of clinical function that have distinct advantages. Among them, since they are formed within the body, they only require minimally invasive procedures, avoiding the pain and risks associated with open surgery. These devices also display enhanced conformability to local tissues and can reach sites that otherwise are inaccessible. This review aims at shedding light on the unique features of in situ generated devices and to underscore leading trends in the field, as they are reflected by key developments recently in the field over the last several years. Since the uniqueness of these devices stems from their in situ generation, the way they are formed is crucial. It is because of this fact that in this review, the medical devices are classified depending on whether their in situ generation entails chemical or physical phenomena.

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Adjustable intraocular lens power technology

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 59 publications

References 39 publications

Optic replacement in a novel modular intraocular lens system

Optic replacement in a novel modular intraocular lens system

Photoreversibility and Biocompatibility of Polydimethylsiloxane‐Coumarin as Adjustable Intraocular Lens Material

In Situ Generated Medical Devices

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