In Situ Generated Medical Devices

Abstract

Medical devices play a major role in all areas of modern medicine, largely contributing to the success of clinical procedures and to the health of patients worldwide. They span from simple commodity products such as gauzes and catheters, to highly advanced implants, e.g., heart valves and vascular grafts. In situ generated devices are an important family of devices that are formed at their site of clinical function that have distinct advantages. Among them, since they are formed within the body, they only require minimally invasive procedures, avoiding the pain and risks associated with open surgery. These devices also display enhanced conformability to local tissues and can reach sites that otherwise are inaccessible. This review aims at shedding light on the unique features of in situ generated devices and to underscore leading trends in the field, as they are reflected by key developments recently in the field over the last several years. Since the uniqueness of these devices stems from their in situ generation, the way they are formed is crucial. It is because of this fact that in this review, the medical devices are classified depending on whether their in situ generation entails chemical or physical phenomena.

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

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Immunochromatography—Application Example and POCT Type Genetic Testing

“…17) Laboratory diagnostic test reagents and laboratory diagnostic equipment have been progressing remarkably these days. 18,19) With these progresses, laboratory diagnostic test reagent achieves highly specific new measurement principles that can measure only the target substance using enzymes and antibodies, improvement of accuracy and sensitivity, expansion of measurement range, reagent stability, and elimination of interfering substances. Laboratory diagnostic equipment helps to achieve shortening measurement time, improvement of through-put, accuracy, elimination of cross-contamination, and less requirement of sample and reagent volume.…”

Polymeric Biomaterials with Complimentary Role in Joint Endoprosthesis. II. Compositional and morpho-structural analysis

“…The successful use of acrylic cements as fixation materials for orthopedic endoprosthesis implies a detailed knowing of various properties and applications of these biomaterials [4][5][6][7].…”