Adenocarcinoma and crohn's disease a report of 2 cases and analysis of the literature

Darke, S. G.; Parks, A. G.; Grogono, J. L.; Pollock, D. J.

doi:10.1002/bjs.1800600302

Cited by 84 publications

(17 citation statements)

References 31 publications

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“…An association between small intestine Crohn's disease and adenocarcinoma of the small intestine has been found [763]. Most adenocarcinomas occur in areas of the small intestine actively involved with Crohn's disease.…”

Section: Colon Cancer Dysplasia and Colonoscopic Surveillancementioning

confidence: 99%

Inflammatory Bowel Disease

Stenson

Hanauer

Cohen

2008

Textbook of Gastroenterology

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In the US, H. pylori vacA shows allelic variation in the signal sequence (which may be type sla, slb or s2) and the mid-region (type ml or m2). Previous PCR-based vacA mid-region typing classified most, but not all, Asian and South American strains tested as ml or m2. We now sought to investigate vacA mid-region diversity further.MotlmodL We studied 13 Japanese, 6 Chinese, 9 Thai, and 8 Peruvian H. pylori isolates. cagA was identified by colony hybridisation (CH), vacA signal sequence was typed by PCR, and vacA mid-region was typed proximally by CH and distally by PCR. Sections of the vacA mid-region from 8 strains were PCR-amplified, sequenced, and compared with known sequences from 8 other strains.Rcuts Of the 36 Asian and South American strains studied, 35 were cagA+ (the cagA-was Peruvian) and 35 were vacA sla (1 cagA + Peruvian was slb). vacA mid-regions from the 13 Japanese strains were not PCR-amplified by ml or m2-specific primers, but hybridised weakly with an ml probe. Sequence analysis of vacA from 1 Japanese strain revealed 91% nucleotide identity with the ml probe but only 71% identity with the m2 probe. The previously equivocal Thai and Peruvian strains also had ml-like mid-region sequences. A Chinese strain was ml in the proximal mid-region and m2 distally, showing a clear crossover site. Final mid-region types were: Japanese, all 13 ml; Chinese, 1 ml, 1 ml/m2, 4 m2; Thai, 3 ml, 6 m2; Peruvian 4 ml, 4 m2. Distal mid-region sequences of 16 strains, compared over 294 bp, clustered into 2 groups, ml and m2. Nucleotide identity between ml and m2 strains ranged from 73-78%. Within groups, m2 strains were less diverse than ml strains (m2 range 94-99.7%, ml 88-99.3%, p<0.001). Sequence analysis of 7 ml and 3 m2 strains over 1.1kb proximally showed maintenance of clustering outside the 294bp region C duions These Asian and South American strains are similar in terms of cagA status and vacA sla genotype, but fall into 2 vacA midregion groups. ml sequences are more diverse than m2, and thus may be phylogenetically older. The vacA sequence of 1 Chinese strain suggests recombination in vivo between ml and m2 alleles. Introduction: H.pylori antimicrobial susceptibility is an important determinant ofthe efficacy of eradication therapies'. The prevalence of antimicrobial resistance varies within the UK and may increase given the increased use of eradication therapy. This multicentre study assesses the prevalence and possible associations ofH.pylon antimicrobial resistance. Methods: H.pylon was isolated from antral biopsies of patients undergoing routine endoscopy and cultured according to standard microbiological methods. Antimicrobial resistance was determined using "E-tests" or disc tests (tinidazole only) with breakpoints defined by previous studies. Results: H.pyloni was isolated from 32% (1222/3823) of patients and antimicrobial susceptibility determined in 90% (1077/1222) Previous case-control studies of IBD have used hospital or community derived controls. There are obvious inherent biases in both metho...

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Section: Colon Cancer Dysplasia and Colonoscopic Surveillancementioning

confidence: 99%

Inflammatory Bowel Disease

Stenson

Hanauer

Cohen

2008

Textbook of Gastroenterology

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“…Adenocarcinoma of both small and large bowel has been most frequently described (Morowitz et al 1968, Wyatt 1969, Darke et al 1973, Weedon et al 1973, Lightdale et al 1975) and reports of nonHodgkin's lymphoma are not uncommon (Hughes 1955, Wybburn-Mason 1968, Fielding et al 1972, Schofield 1972, Collins 1977. It was not until 1977 that the first description was published of Hodgkin's disease developing in a patient with Crohn's disease (Codling et al 1977), although since then 3 further cases, all adults, have been reported (Table 1) The present case differs in two ways from the 4 previously described: first, in our patient both diseases presented in childhood; secondly, there was no evidence of infradiaphragmatic Hodgkin's disease, in particular no bowel involvement.…”

Section: Discussionmentioning

confidence: 99%

Hodgkin's Disease Complicating Crohn's Disease in a Child

et al. 1985

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“…Sie sind dann meist in der l iefe der verdickten Darmschleimhaut lokalisiert. Im Dünndarm präsentierten sich von 58 Karzinomen 39 im Rahmen einer Obstruktion, eine an und für sich ohnehin typische Komplika tion des Morbus Crohn [7], Die Diagnose eines Crohn-assoziierten Karzinoms wird daher meist sehr spät gestellt, und es er gibt sich daher eine entsprechend schlechte Fünf-Jahres-Über-lebensrate von IX% |I7|.…”

Section: Stellenwert Der Endoskopie In Der Erfassung Von Crohn-assoziunclassified

Chronisch entzündliche Erkrankungen des Kolons und des Rektums

Petritsch¹,

Krejs²

1992

Chir Gastroenterol

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Die Colitis ulcerosa und der Morbus Crohn sind Erkrankungen mit einem erhöhten Krebsrisiko. Bei der Colitis ulcerosa ist das Entartungsrisiko vom Ausmaβ des Befalles und vom Alter des Patienten zur Zeit der Diagnosestellung abhängig. Bei Patienten mit einer Pankolitis oder linksseitigen Kolitis, die zur Zeit der Diagnose jünger als 40 Jahre alt sind, liegt das Entartungsrisiko erst nach 15 bis 20 Jahren signifikant über dem der Normalbevölkerung. Anders bei Patienten, die zum Zeitpunkt der Diagnose alter als 40 Jahre sind. Bei diesen Patienten liegt bereits nach zehn Jahren ein vergleichsweise höheres Krebsrisiko vor. So kommt es z.B. 15 Jahre nach Auftreten einer Pankolitis, die vor dem 40. Lebensjahr begann, bei 3% zu einem Karzinom. Bei Krankheitsbeginn nach dem 40. Lebensjahr liegt jedoch 15 Jahre nach Auftreten der Pankolitis bereits bei 12% der Patienten ein Karzinom vor. Entsprechende koloskopische Kontrollen mit Biopsien sind zur Abschätzung des individuellen Entartungsrisikos daher zehn bis 15 Jahre nach Krankheitsbeginn regelmäβig durchzuführen. Endoskopisch imponieren Kolitisassoziierte Karzinome oder verdächtige Läsionen meist als Strikturen und als plaqueähnliche oder polypoide Bezirke. Gröβere oder ulzerierte Tumore sind selten. Im Gegensatz zur Colitis ulcerosa war das erhöhte Krebsrisiko bei Patienten mit einem Morbus Crohn bis vor einigen Jahren nicht gesichert. Crohn-assoziierte Karzinome können im Dunn- und Dickdarm vorkommen. Besonders gefährdet scheint der Bereich von Fisteln, Strikturen und blinden Schlingen nach Bypassoperationen zu sein. Ob eine routinemäβige Kontrolle solcher Patienten sinnvoll ist, muβ erst durch prospektive Studien oder zumindest durch mehr klinische Erfahrung mit solchen Patienten belegt werden.

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Adenocarcinoma and crohn's disease a report of 2 cases and analysis of the literature

Cited by 84 publications

References 31 publications

Inflammatory Bowel Disease

Inflammatory Bowel Disease

Hodgkin's Disease Complicating Crohn's Disease in a Child

Chronisch entzündliche Erkrankungen des Kolons und des Rektums

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Adenocarcinoma and crohn's disease a report of 2 cases and analysis of the literature

Cited by 84 publications

References 31 publications

Inflammatory Bowel Disease

Inflammatory Bowel Disease

Hodgkin's Disease Complicating Crohn's Disease in a Child

Chronisch entz&uuml;ndliche Erkrankungen des Kolons und des Rektums

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Chronisch entzündliche Erkrankungen des Kolons und des Rektums