SUMMARY A series of 50 children with agenesis of the corpus callosum is described. The incidence of this rare abnormality and the problem of diagnosing the more normal cases in life are discussed. Long term follow‐up is planned as there remain many unanswered problems in the understanding of the functions of the corpus callosum. RÉSUMÉ Une série de 50 enfants présentant une agénésie du corpus callosum a étéétudiée. La fréquence de survenue de cette rare anomalie et les problèmes diagnostiques posés par les cas plus normaux sont discutés. Une etude longitudinale est envisagée car de nombreux problèmes restent à résoudre pour comprendre les fonctions du corpus callosum. ZUSAMMENFASSUNG Es wird eine Serie von 50 Kindern mit Agénésie des Corpus callosum beschrieben. Das Auftreten dieser seltenen Abnormität und das Problem, die Fälle mit fast normaler Neurologie am lebenden zu diagnostizieren, wurden besprochen. Eine langfristige Studie mit Nachuntersuchungen ist geplant, da viele Fragen zur Funktion des Corpus callosum unbeantwortet blieben. RESUMEN Se describe una serie de cincuenta niños afectos de agenesia del cuerpo calloso. Se discuten la frecuencia de esta anormalidad raia y el problema de diagnosticar mientras viven los casos más cerca de lo normal. Hay proyectos para proseguir indagaciones a largo plazo, puesto que quedan sin respuesta muchos problemas al sujeto de las funciones del cuerpo calloso.
Two cases of carcinoma developing in a segment of Crohn's disease are described, one in the large intestine and one in the small intestine. From an analysis of the literature, evidence is advanced with regard to age at the time of developing carcinoma, duration of symptoms attributable to Crohn's disease, anatomical distribution, and observed incidence compared with chance incidence. It is concluded that there is a small but significant risk of carcinoma developing, both in the small and large intestines, in Crohn's disease.
SUMMARY A review of all patients with ulcerative colitis in one health district between 1975-84 revealed an incidence and prevalence of 7.1 and 84/100000 population respectively. One hundred and ninety five new patients were diagnosed and 313 patients seen and followed up in the clinic for 1168 patient years. None of these patients died from colitis or a complication. On routine colonoscopy three cases had high grade dysplasia and two asymptomatic carcinomas (Duke's stage A and B). Eighty four patients were known to have ulcerative colitis, but were lost to follow up from the hospital clinic; the total time they were not under hospital surveillance was 315 patient years. At the end of the study these patients were contacted or clinical details obtained from their general practitioners. Five of these patients subsequently presented with symptomatic carcinomas (two Duke's B, one Duke's C and two with metastases
SUMMARY Five cases of carcinoma of the urachus are reported. The factors contributing to the poor prognosis are discussed. Improved survival may follow earlier diagnosis; a biopsy should be taken from all isolated tumours at the bladder apex, and if the tumour is found to be an adenocarcinoma the urachus is the most likely site of origin. Treatment is by radical surgery in early cases; the place of radiotherapy is as yet undecided.
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