Addition of Platelet-Rich Plasma to Silk Fibroin Hydrogel Bioprinting for Cartilage Regeneration

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

“…Applying this particular technique, researchers have reported the production of cartilage-like constructs through the combination of various hydrogels [46,[182][183][184][185][186][187][188]; However, the most efficient strategy has involved simultaneous deposition of thermoplastic polymers utilizing multi-dispenser systems while structural materials able of maintaining mechanical forces, and hydrogels as cell carriers [189][190][191][192][193][194]. Besides, researchers have endeavored to modify bioinks' attributes, such as printability, mechanical properties, and degradation rate [177,178,195,196].…”

3D Bioprinting of Biomimetic Bilayered Scaffold Consisting of Decellularized Extracellular Matrix and Silk Fibroin for Osteochondral Repair

“…However, the mechanical strength of DCM and DBM is insufficient because of the loss of cartilage/bone native tissue structure during the homogenization and solubilization process[ 36 , 37 ]. Silk fibroin (SF) is a natural biopolymer that is widely investigated for various 3D bioprinting and tissue engineering applications due to its remarkable mechanical properties, biocompatibility and biodegradation nature[ 38 , 39 ]. In our previous study, we reported the use of a cross-linker-free DCM-SF bioink in printing 3D construct which had similar mechanical properties compared with native cartilage tissue[ 37 ].…”

3D bioprinting of photo‐crosslinkable silk methacrylate (SilMA)‐polyethylene glycol diacrylate (PEGDA) bioink for cartilage tissue engineering

“…Furthermore, tissue engineering and other biofabrication approaches utilizing biomaterials, cells and growth factors gained much prominence for cartilage tissue regeneration. 1,2,6 In the quest for therapies that enhance cartilage repair, various biofabrication strategies are being explored since last decade. Three dimensional (3D) bioprinting is a leading biofabrication strategy for overcoming difficulties associated with current treatments for cartilage tissue regeneration and is being utilized for design and production of various living tissue constructs on demand.…”