Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

Askari, Mohsen; Naniz, Moqaddaseh Afzali; Kouhi, Monireh; Saberi, Azadeh; Zolfagharian, Ali; Bodaghi, Mahdi

doi:10.1039/d0bm00973c

Cited by 221 publications

(109 citation statements)

References 345 publications

(406 reference statements)

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“…using viscous materials) onto a build plate, where each layer is purposely built upon the previous layer for adherence until the whole part is entirely fabricated. [ 13 , 34 , 37 ] These methods are known as direct ink writing (DIW) or viscous solution printing (VSP). Inkjet printing is a digital printing process that uses two different processes for 3D printing hydrogels: (1) controlled droplets of liquid material deposited directly onto a substrate that solidifies upon curing; and (2) powder-bed based printing, where the ink, serving as a binder, is deposited from a controlled nozzle to a bed of powder materials bound into multiple layers to create the printed parts.…”

Section: Brief Review Of Additive Manufacturingmentioning

confidence: 99%

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On the progress of 3D-printed hydrogels for tissue engineering

et al. 2021

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Additive manufacturing or more commonly known as 3D printing, is currently driving innovations and applications in diverse fields such as prototyping, manufacturing, aerospace, education, and medicine. Recent technological and materials research breakthroughs have enabled 3D bioprinting, where biomaterials and cells are used to create scaffolds and functional living tissues (e.g. skin, cartilage, etc.). This prospective focuses on the classification and applications of hydrogels, and design considerations in their production (i.e. physical and biological parameters). The materials for 3D printing of hydrogels, such as biopolymers, synthetic polymers, and nanocomposites, are mainly discussed. More importantly, future perspectives on 3D printing hydrogels including new materials, 4D printing, emerging printing technologies, etc. and their importance in biomedical and bioengineering applications are discussed. Graphic Abstract

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Section: Brief Review Of Additive Manufacturingmentioning

confidence: 99%

“…increases heterogeneity). [ 37 ] There is a possibility that this method can be extended to hydrogel and bioprinting, resulting in better geometry and distribution of material control.…”

Section: Future Outlookmentioning

confidence: 99%

On the progress of 3D-printed hydrogels for tissue engineering

et al. 2021

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“…Many progresses in 3D bioprinting of hydrogel-based biomaterials have also been recently discussed from the tissue engineering perspective. In this case, differently from the prosthetic approach, the attention has been focused on hydrogel-based bioprinted scaffolds to develop functional tissues through the use of advanced fabrication methods covering multiple-dispenser, coaxial and hybrid 3D printing processes [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…Even though many progresses have been made in the design of lattice structures, 3D printed scaffolds for tissue regeneration and advanced prosthesis [ 30 , 31 , 36 , 39 , 40 , 43 , 44 , 45 , 46 , 47 ], the aim of the current investigation was to design and fabricate customized hybrid devices as a further alternative for the repair of large cranial defects, integrating the reverse engineering approach with additive manufacturing. The hybrid device consisted of a 3D additive manufactured polyester porous structures infiltrated with PMMA/Cu-TCP (97.5/2.5 w / w ) bone cement.…”

Section: Introductionmentioning

confidence: 99%

Design of 3D Additively Manufactured Hybrid Structures for Cranioplasty

et al. 2021

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A wide range of materials has been considered to repair cranial defects. In the field of cranioplasty, poly(methyl methacrylate) (PMMA)-based bone cements and modifications through the inclusion of copper doped tricalcium phosphate (Cu-TCP) particles have been already investigated. On the other hand, aliphatic polyesters such as poly(ε-caprolactone) (PCL) and polylactic acid (PLA) have been frequently investigated to make scaffolds for cranial bone regeneration. Accordingly, the aim of the current research was to design and fabricate customized hybrid devices for the repair of large cranial defects integrating the reverse engineering approach with additive manufacturing, The hybrid device consisted of a 3D additive manufactured polyester porous structures infiltrated with PMMA/Cu-TCP (97.5/2.5 w/w) bone cement. Temperature profiles were first evaluated for 3D hybrid devices (PCL/PMMA, PLA/PMMA, PCL/PMMA/Cu-TCP and PLA/PMMA/Cu-TCP). Peak temperatures recorded for hybrid PCL/PMMA and PCL/PMMA/Cu-TCP were significantly lower than those found for the PLA-based ones. Virtual and physical models of customized devices for large cranial defect were developed to assess the feasibility of the proposed technical solutions. A theoretical analysis was preliminarily performed on the entire head model trying to simulate severe impact conditions for people with the customized hybrid device (PCL/PMMA/Cu-TCP) (i.e., a rigid sphere impacting the implant region of the head). Results from finite element analysis (FEA) provided information on the different components of the model.

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“…Yet, due to the novelty of this niche market, no bioprinter reviews that we could find focus on the latest commercially available low-cost systems. Specifically, the previously published reviews either give an overview of the entire bioprinting field (with a focus on the evolution of the printing technologies), 9–13 review bio-inks, 14–27 or discuss specific applications (e.g., cardiovascular tissue models, 14,28–35 bone tissue models, 36–48 cartilage tissue models, 42,47,49–52 nerve tissue models, 53–61 skin tissue models, 48,62–66 and in vivo bioprinting 67–…”

Section: Introductionmentioning

confidence: 99%

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

et al. 2021

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Three-dimensional (3D) bioprinting has become mainstream for precise and repeatable high-throughput fabrication of complex cell cultures and tissue constructs in drug testing and regenerative medicine, food products, dental and medical implants, biosensors, and so forth. Due to this tremendous growth in demand, an overwhelming amount of hardware manufacturers have recently flooded the market with different types of low-cost bioprinter models—a price segment that is most affordable to typical-sized laboratories. These machines range in sophistication, type of the underlying printing technology, and possible add-ons/features, which makes the selection process rather daunting (especially for a nonexpert customer). Yet, the review articles available in the literature mostly focus on the technical aspects of the printer technologies under development, as opposed to explaining the differences in what is already on the market. In contrast, this paper provides a snapshot of the fast-evolving low-cost bioprinter niche, as well as reputation profiles (relevant to delivery time, part quality, adherence to specifications, warranty, maintenance, etc.) of the companies selling these machines. Specifically, models spanning three dominant technologies—microextrusion, droplet-based/inkjet, and light-based/crosslinking—are reviewed. Additionally, representative examples of high-end competitors (including up-and-coming microfluidics-based bioprinters) are discussed to highlight their major differences and advantages relative to the low-cost models. Finally, forecasts are made based on the trends observed during this survey, as to the anticipated trickling down of the high-end technologies to the low-cost printers. Overall, this paper provides insight for guiding buyers on a limited budget toward making informed purchasing decisions in this fast-paced market.

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Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

Abstract: Over the last decade, 3D bioprinting has received immense attention from research communities for developing functional tissues. Thanks to the complexity of tissues, various bioprinting methods are exploited to figure...

Cited by 221 publications

References 345 publications

On the progress of 3D-printed hydrogels for tissue engineering

On the progress of 3D-printed hydrogels for tissue engineering

Design of 3D Additively Manufactured Hybrid Structures for Cranioplasty

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

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