On the progress of 3D-printed hydrogels for tissue engineering

Advíncula, Rigoberto C.; Dizon, John Ryan C.; Caldona, Eugene B.; Viers, Robert Andrew; Siacor, Francis Dave C.; Maalihan, Reymark D.; Espera, Alejandro H.

doi:10.1557/s43579-021-00069-1

Cited by 80 publications

(46 citation statements)

References 100 publications

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“…30 So, it is vital to incorporate hydrophilic biomaterials or ECM proteins as components of scaffold and achieve functionalization with bioactive motifs to promote cell adhesion. 31,32 T A B L E 1 Advantages and disadvantages of various biomaterials used in bone, cartilage, and osteochondral tissue engineering…”

Section: Cell Adhesionmentioning

confidence: 99%

Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects

Anandhapadman¹,

Venkateswaran²,

Jayaraman³

et al. 2022

Biotechnology Progress

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The conventional methods of using autografts and allografts for repairing defects in bone, the osteochondral bone, and the cartilage tissue have many disadvantages, like donor site morbidity and shortage of donors. Moreover, only 30% of the implanted grafts are shown to be successful in treating the defects. Hence, exploring alternative techniques such as tissue engineering to treat bone tissue associated defects is promising as it eliminates the above‐mentioned limitations. To enhance the mechanical and biological properties of the tissue engineered product, it is essential to fabricate the scaffold used in tissue engineering by the combination of various biomaterials. Three‐dimensional (3D) printing, with its ability to print composite materials and with complex geometry seems to have a huge potential in scaffold fabrication technique for engineering bone associated tissues. This review summarizes the recent applications and future perspectives of 3D printing technologies in the fabrication of composite scaffolds used in bone, osteochondral, and cartilage tissue engineering. Key developments in the field of 3D printing technologies involves the incorporation of various biomaterials and cells in printing composite scaffolds mimicking physiologically relevant complex geometry and gradient porosity. Much recently, the emerging trend of printing smart scaffolds which can respond to external stimulus such as temperature, pH and magnetic field, known as 4D printing is gaining immense popularity and can be considered as the future of 3D printing applications in the field of tissue engineering.

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Section: Cell Adhesionmentioning

confidence: 99%

Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects

Anandhapadman¹,

Venkateswaran²,

Jayaraman³

et al. 2022

Biotechnology Progress

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“…Although Gel 3D printing is widely used in the fabrication of complex devices, the specific fluid properties and curable nature of droplets also hinder the development of inkjet printing ( Zhang B. et al, 2018 ). The functionality of printed parts depends primarily on the inherent bioactivity of the hydrogel and the retention of contained cells and growth factors ( Unal and West, 2020 ; Advincula et al, 2021 ). However, the contradiction between printability and structural stability of most hydrogels is not conducive to obtaining high printing accuracy, self-support, and structural fidelity, which is an urgent problem to be solved in the field of bio-3D printing.…”

Section: Inkjet Printing and Laser Assisted Bioprintingmentioning

confidence: 99%

Current Advances and Future Perspectives of Advanced Polymer Processing for Bone and Tissue Engineering: Morphological Control and Applications

Zhang

Nie

2022

Front. Bioeng. Biotechnol.

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Advanced polymer processing has received extensive attention due to its unique control of complex force fields and customizability, and has been widely applied in various fields, especially in preparation of functional devices for bioengineering and biotechnology. This review aims to provide an overview of various advanced polymer processing techniques including rotation extrusion, electrospinning, micro injection molding, 3D printing and their recent progresses in the field of cell proliferation, bone repair, and artificial blood vessels. This review dose not only attempts to provide a comprehensive understanding of advanced polymer processing, but also aims to guide for design and fabrication of next-generation device for biomedical engineering.

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“…R.C. Advincula et al presented an overview of progress in the development of 3D printed hydrogels used for tissue engineering applications [ 27 ]. The scope of the review included natural, synthetic, and nanocomposite polymers and their design considerations for 3D printing.…”

Section: Introductionmentioning

confidence: 99%

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

2022

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Wounds are a major health concern affecting the lives of millions of people. Some wounds may pass a threshold diameter to become unrecoverable by themselves. These wounds become chronic and may even lead to mortality. Recently, 3D printing technology, in association with biocompatible hydrogels, has emerged as a promising platform for developing smart wound dressings, overcoming several challenges. 3D printed wound dressings can be loaded with a variety of items, such as antibiotics, antibacterial nanoparticles, and other drugs that can accelerate wound healing rate. 3D printing is computerized, allowing each level of the printed part to be fully controlled in situ to produce the dressings desired. In this review, recent developments in hydrogel-based wound dressings made using 3D printing are covered. The most common biosensors integrated with 3D printed hydrogels for wound dressing applications are comprehensively discussed. Fundamental challenges for 3D printing and future prospects are highlighted. Additionally, some related nanomaterial-based hydrogels are recommended for future consideration.

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On the progress of 3D-printed hydrogels for tissue engineering

Cited by 80 publications

References 100 publications

Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects

Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects

Current Advances and Future Perspectives of Advanced Polymer Processing for Bone and Tissue Engineering: Morphological Control and Applications

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

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