Adaptation of capillary electrophoresis to the determination of selected cephalosporins for injection

High Performance Liquid Chromatographic Method for the Quantitative Analysis of Cefuroxime in Pharmaceutical Preparations

“…Some of the analytical methods are reported for the assay of cefuroxime in marketed form includes spectrophotometry [5][6][7][8], High performance liquid chromatography (HPLC) [9][10][11], Capillary electrophoresis [12][13][14], HPTLC [15] and LC-MS/MS [16]. The current communication proposes simple analytical procedure to quantify cefuroxime in pure and marketed products using HPLC.…”

Study of the Electrophoretic Behavior of Cephalosporins by Capillary Zone Electrophoresis

“…[6][7][8] Separating simultaneously different types of cephalosporins from different generations remains a challenging task for HPLC, but the resolving power of CE can make this separation relatively fast and simple. 6 Cephalosporins are analyzed usually through two different electrophoretic techniques: capillary zone electrophoresis (CZE) [9][10][11][12][13][14][15] used for the separation of ionic or ionogenic cephalosporins when separation is based on the differences between the electrophoretic mobilities of the analytes; and micellar electrokinetic chromatography (MEKC) [16][17][18][19] used for the separation of both neutral and/or ionic or ionogenic cephalosporins when separation is based on the generation of a pseudostationary phase in which analyte partition takes place. CE has been successfully applied for the analysis of cephalosporins from different pharmaceutical forms, 15 environmental samples, 14 plasma, 9 blood serum, 20 urine and bile, 10 bronchial secretion, 13 but also in stability studies 12 and for the determination of dissociation constants.…”

“…Previously published methods exemplify the fact that the simultaneous determination of structurally related cephalosporins is challenging because of their similar electrophoretic mobilities. 9,12,14,15,18,19 For this reason, both structurally related cephalosporins from the same generation (CFL, CFD and CCL) and cephalosporins from different generations and different structural characteristics were chosen as the subject of the present study. This paper presents a comprehensive study of the electrophoretic behavior of cephalosporins from different generations and also the development of a generic simulataneous separation method of several cephalosporins from complex mixtures.…”

Analysis of cephalosporins by hydrophilic interaction chromatography

“…Capillary HPLC is also used to analyze cephalosporins at lower concentration [11,12], which is especially suitable for the trace determination of cephalosporins in environmental and food samples. Besides the HPLC method, cephalosporins can also be analyzed by capillary electrophoresis [13] and ion-exchange planar electrochromatography [14].…”