High Performance Liquid Chromatographic Method for the Quantitative Analysis of Cefuroxime in Pharmaceutical Preparations

Siddiqui, Masoom Raza; ALOthman, Zeid A.; Wabaidur, Saikh Mohammad; Khan, Moonis Ali; Alam, Sarfaraz; Ali, Sajid

doi:10.4067/s0717-97072015000200001

Cited by 7 publications

(3 citation statements)

References 4 publications

(4 reference statements)

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“…HPLC method has a shorter analysis time of 10 min. The developed method obeyed the Beer's law in the range of 5-300 μg.mL -1 [32].…”

Section: Introductionmentioning

confidence: 93%

“…Various spectrophotometric [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], High Performance Liquid Chromatographic (HPLC), Reversed-phase high performance liquid chromatography (RP-HPLC), high performance thin layer chromatographic (HPTLC), micellar liquid chromatographic (MLC) [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] and voltammetric [38,39] methods have been reported for the determination of cefuroxime.…”

Section: Introductionmentioning

confidence: 99%

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Direct Spectrophotometric Determination of Cefuroxime Axetil in Pure Form and Pharmaceutical Dosage Forms.

Ramadan

Bakdash

2018

JAC

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A simple, direct and cost-effective spectrophotometric method for determination of cefuroxime axetil (CRXA) in pure and tablet dosage forms was applied. This method is based on formation of ion-pair complex ([CRXA]:[BTB]) between CRXA and bromothymol blue (BTB) in chloroform. Beer’s law in the optimum experimental conditions using [CRXA]:[BTB] complex is valid within a concentration range of 2.00-50.00 ?M (1.021–25.524 ?g.mL-1). The developed method is applied for the determination of CRXA in pure and its commercial tablets without any interference from excipients with average assay of 96.8 to 101.6% and the results are in good agreement with those obtained by the HPLC reference method. Associated drugs (sulbactam and linesolid) with cefuroxime axetil are considered to be interfere, while metronidazole can be considered as non-interfere.

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“…HPLC method has a shorter analysis time of 10 min. The developed method obeyed the Beer's law in the range of 5-300 μg.mL -1 [32].…”

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Direct Spectrophotometric Determination of Cefuroxime Axetil in Pure Form and Pharmaceutical Dosage Forms.

Ramadan

Bakdash

2018

JAC

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“…HPLC and mass spectrometry‐based methods have also been described, but they needed for expensive, specialized equipment that is not often found in laboratories. [ 3,4 ]…”

Section: Introductionmentioning

confidence: 99%

RP HPLC Enabled Novel Analytical Method for the Development and Quantification of Cefuroxime Axetil in its Bulk Drug and Pharmaceutical Formulations

Mishra,

Behera,

Kar

et al. 2024

Macromolecular Symposia

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Current investigations aim to develop and validate an accurate, simple, specific, and precise RP‐HPLC method for the detection of cefuroxime axetil, in bulk and tablet dosage forms. Despite extensive literature reviews, no method could be found for estimating the variables mentioned above. The chromatographic separation is achieved on Sunfire C18 column (250 mm × 4.6 mm, 5 µm) of HPLC (Agilent Tech 1100), with 5 µm mobile phase composed of methanol, orthophosphoric acid (0.05%) adjusted to a pH of 3.0 in water, 40:60% v/v triethylamine using isocratic mode of elution, at wavelength 278.0 nm using UV Spectrophotometer, temperature 25 °C, detection is done. The developed method is done as per ICH guidelines. A linear calibration curve is found to be linear in concentrations between 1 and 5 µg mL−1 (r2 = 0.9995). The percentage recoveries of cefuroxime axetil are found to be in the range of 95.68–96.98%. The percentage of relative standard deviations in intraday trials is found to be 0.61, 0.66, and 0.88, respectively, and in interday studies are 0.06, 0.16, and 0.29, respectively, demonstrating good accuracy and little variance. The proposed method is highly sensitive, robust, precise, accurate, and the use of green solvents makes this method safe and efficacious.

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A capillary coated with a metal-organic framework for the capillary electrochromatographic determination of cephalosporins

Wang

et al. 2017

Microchim Acta

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High Performance Liquid Chromatographic Method for the Quantitative Analysis of Cefuroxime in Pharmaceutical Preparations

Cited by 7 publications

References 4 publications

Direct Spectrophotometric Determination of Cefuroxime Axetil in Pure Form and Pharmaceutical Dosage Forms.

Direct Spectrophotometric Determination of Cefuroxime Axetil in Pure Form and Pharmaceutical Dosage Forms.

RP HPLC Enabled Novel Analytical Method for the Development and Quantification of Cefuroxime Axetil in its Bulk Drug and Pharmaceutical Formulations

A capillary coated with a metal-organic framework for the capillary electrochromatographic determination of cephalosporins

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