Acute Tubular Necrosis Associated with Non-Hemorrhagic Dengue Fever: A Case Report

Mohsin, Nabil; Mohamed, EsraaA; Gaber, Mona; Obaidani, I.; Budruddin, M.; Busaidy, Salim Al

doi:10.3109/08860220903003404

Cited by 20 publications

(17 citation statements)

References 16 publications

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“…Renal disorders associated with DENV have not been extensively studied; available data are heterogeneous and the majority of information comes from case series or reports, in which the incidence varies from 0.3% to 13.3% . Renal complications include acute tubular necrosis, tubulointerstitial nephritis, TMA, nephritic, and nephrotic syndrome . The risk factors associated with acute kidney injury (AKI) in dengue are old age, male gender, severe dengue, shock, neurological involvement, prolonged activated partial thromboplastin time, and use of nephrotoxic drugs .…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of thrombotic microangiopathy associated with dengue infection: A case report and literature review

Nieto-Ríos

Barreneche

Penagos

et al. 2018

Transplant Infectious Dis

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Dengue infection has been associated with multiple renal complications, including glomerulonephritis, acute tubular necrosis, tubulointerstitial nephritis, and thrombotic microangiopathy (TMA), this last one being a rare complication of dengue, with only a few reported cases. TMA associated with dengue can be explained by an alteration in the activity of the enzyme ADAMTS13, leading to thrombotic thrombocytopenic purpura; or it can be secondary to direct or indirect endothelial injury by the virus, which leads to hemolytic uremic syndrome. Here, we present a case of severe TMA, not related to ADAMTS13, which was clearly associated with dengue infection.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of thrombotic microangiopathy associated with dengue infection: A case report and literature review

Nieto-Ríos

Barreneche

Penagos

et al. 2018

Transplant Infectious Dis

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“…Hemodynamic instability, hemolysis, glomerular injury and direct action of viral particles on renal tissue have been considered as possible injury mechanisms 6,10,25,30,32,34,37 . In fact, the current patient presented proteinuria but the renal biopsy did not disclose glomerular injury.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of AKI have been associated with DHF or DSS 6,7,20–23,25,27,34,40 , but AKI has also been described in DF 13–15,30,31 , albeit less commonly. Similarly, rhabdomyolysis with 1,5,7,19 and without AKI 9,24,28 has been described in dengue patients.…”

Section: Introductionmentioning

confidence: 99%

Biopsy Proven Acute Tubular Necrosis Due to Rhabdomyolysis in a Dengue Fever Patient: A Case Report and Review of Literature

Repizo

Malheiros

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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Renal histology results are very scarce in dengue-associated rhabdomyolysis patients developing acute kidney injury (AKI). We report a case of dengue fever-induced AKI associated to rhabdomyolysis with a renal biopsy showing acute tubular necrosis (ATN) and renal deposition of myoglobin. A 28-year-old patient who presented dengue fever (DF) complicated by severe AKI and rhabdomyolysis is described. The patient required hemodialysis for three weeks. A renal biopsy revealed ATN with positive staining for myoglobin in the renal tubuli. The patient was discharged with recovered renal function. In conclusion, this case report described a biopsy proven ATN associated to DF-induced rhabdomyolysis, in which renal deposition of myoglobin was demonstrated. We suggest that serum creatine phosphokinase should be monitored in DF patients to allow for an early diagnosis of rhabdomyolysis and the institution of renal protective measures.

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“…There is eventual recovery of renal function in most cases of dengue-induced renal damage, as in our case. 1,3,7,9,11 The precise mechanism of renal involvement in patients with DHF in the absence of bleeding, sepsis or hypotension is not clear. Various hypotheses have been advanced, including the direct cytopathic effects of viral proteins on glomerular and tubular cells, insitu immune-mediated mechanisms involving viral antigens bound to glomerular structures, injury owing to circulating immune complexes and various inflammatory mediators released in response to glomerular or tubular cytopathic effects.…”

Section: Discussionmentioning

confidence: 99%

Acute glomerulonephritis in dengue haemorrhagic fever in the absence of shock, sepsis, haemolysis or rhabdomyolysis

Bhagat

Zaki

Sharma

et al. 2012

Paediatrics and International Child Health

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Renal damage in dengue haemorrhagic fever (DHF) has been reported in association with shock, haemolysis, rhabdomyolysis and sepsis. This report describes acute glomerulonephritis with DHF without the above-mentioned complications. A 3-year-old boy presented with fever, vomiting and oliguria. He had hypertension, deranged renal function and low serum complement (C3), and urine microscopy showed red blood cells and granular casts. The IgM and IgG ELISA (rapid test) for dengue virus were positive. He was managed with maintenance fluids, intravenous furosemide and supportive care. He made an uneventful recovery and was discharged 7 days after admission.

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Acute Tubular Necrosis Associated with Non-Hemorrhagic Dengue Fever: A Case Report

Cited by 20 publications

References 16 publications

Successful treatment of thrombotic microangiopathy associated with dengue infection: A case report and literature review

Successful treatment of thrombotic microangiopathy associated with dengue infection: A case report and literature review

Biopsy Proven Acute Tubular Necrosis Due to Rhabdomyolysis in a Dengue Fever Patient: A Case Report and Review of Literature

Acute glomerulonephritis in dengue haemorrhagic fever in the absence of shock, sepsis, haemolysis or rhabdomyolysis

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