Acute glomerulonephritis in dengue haemorrhagic fever in the absence of shock, sepsis, haemolysis or rhabdomyolysis

Bhagat, Manish; Zaki, Syed Ahmed; Sharma, S.; Manglani, Mamta

doi:10.1179/2046905512y.0000000001

Cited by 21 publications

(10 citation statements)

References 11 publications

(14 reference statements)

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“…Clinical studies to confirm the presence of orchitis and to assess the fertility of convalescent male patients should be conducted to ascertain the long-term consequences of ZIKV infection regarding reproductive and hormonal derangements. Inflammation of other organs, such as acute tubulitis, interstitial nephritis, sialadenitis, hepatitis, enteritis, and acute pancreatitis have been reported in patients with ZIKV or other flavivirus infections (Chan et al, 2016a;Sarmiento-Ospina et al, 2016;Arzuza-Ortega et al, 2016;Duijster et al, 2016;Bonaldo et al, 2016;Gourinat et al, 2015;Musso et al, 2015b;Mercado et al, 2016;Bhagat et al, 2012;Torres et al, 2000;Macnamara, 1954;Chatterjee et al, 2014). These potential complications may be increasingly recognized as the ZIKV epidemic continues to expand into developed countries with a large ageing and immunosuppressed population.…”

Section: Discussionmentioning

confidence: 99%

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

et al. 2016

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BackgroundDisseminated or fatal Zika virus (ZIKV) infections were reported in immunosuppressed patients. Existing interferon-signaling/receptor-deficient mouse models may not be suitable for evaluating treatment effects of recombinant interferons.MethodsWe developed a novel mouse model for ZIKV infection by immunosuppressing BALB/c mice with dexamethasone.ResultsDexamethasone-immunosuppressed male mice (6–8 weeks) developed disseminated infection as evidenced by the detection of ZIKV-NS1 protein expression and high viral loads in multiple organs. They had ≥ 10% weight loss and high clinical scores soon after dexamethasone withdrawal (10 dpi), which warranted euthanasia at 12 dpi. Viral loads in blood and most tissues at 5 dpi were significantly higher than those at 12 dpi (P < 0.05). Histological examination revealed prominent inflammatory infiltrates in multiple organs, and CD45 + and CD8 + inflammatory cells were seen in the testis. These findings suggested that clinical deterioration occurred during viral clearance by host immune response. Type I interferon treatments improved clinical outcome of mice (100% vs 0% survival).ConclusionsBesides virus dissemination, inflammation of various tissues, especially orchitis, may be potential complications of ZIKV infection with significant implications on disease transmission and male fertility. Interferon treatment should be considered in patients at high risks for ZIKV-associated complications when the potential benefits outweigh the side effects of treatment.

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Section: Discussionmentioning

confidence: 99%

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

et al. 2016

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“…Various symptoms indicating the possible involvement of kidney in DENV infection have been reported which includes proteinuria, hematuria, various types of glomerulonephritis, acute kidney injury (AKI), elevated serum creatinine level, acute tubular necrosis and hemolytic uremic syndrome [15,20,[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95]. Nevertheless, the importance of this organ in sustaining DENV infection has not been well explored.…”

Section: Kidneymentioning

confidence: 99%

Insight into the Tropism of Dengue Virus in Humans

Begum

Das

Mukherjee

et al. 2019

Viruses

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In tropical and subtropical zones, arboviruses are among the major threats to human life, affecting a large number of populations with serious diseases. Worldwide, over three hundred million people are infected with dengue virus (DENV) every year as per the World Health Organization (WHO). DENV-mediated disease severity ranges from a mild fever to hemorrhagic fever and shock syndrome. Patients suffering from severe infection might experience multi-organ failure, cardiomyopathy and even encephalopathy, further complicating the disease pathogenesis. In life-threatening cases, DENV has been reported to affect almost all organs of the human body. In this review, we discuss the organ tropism of DENV in humans in depth as detected in various autopsy studies. Keeping in mind the fact that there is currently no DENV-specific antiviral, it is of utmost importance to achieve a vivid picture of the susceptible cells in humans which might help in designing antivirals against DENV, especially targeting those tissues in which infection might lead to life-threatening conditions.

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“…[1] Only one case has been reported till date. [3] We are reporting a case of dengue hemorrhagic fever presenting with acute glomerulonephritis.…”

Section: Introductionmentioning

confidence: 98%

Acute glomerulonephritis in dengue hemorrhagic fever: A rare case report

Meena

Kumar

Anita

et al. 2013

Ann Trop Med Public Health

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An 11-year-old male child presented with fever, bodyache, swelling over the whole body, and oliguria. He had hypertension. Urine microscopy showed hematuria and glomerular casts. Renal functions were deranged and had low complement C3 level. Chest X-ray showed plural effusion and ultrasonography abdomen showed mild ascitis. The immunoglobulin (Ig)M and IgG enzyme-linked immunosorbent essay for dengue virus were positive. Diagnosis of dengue hemorrhagic fever with acute glomerulonephritis was made. He was managed with maintenance luid, antihypertensive medicine and supportive care. He recovered gradually and was discharged 12 days after admission.

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Acute glomerulonephritis in dengue haemorrhagic fever in the absence of shock, sepsis, haemolysis or rhabdomyolysis

Cited by 21 publications

References 11 publications

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

Insight into the Tropism of Dengue Virus in Humans

Acute glomerulonephritis in dengue hemorrhagic fever: A rare case report

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