Acute treatment with <i>Mangifera indica</i> L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet

Toledo, Renata Celi Lopes; Brito, Larissa Froede; Caetano, Mônica Maria Magalhães; Nakajima, Vânia Mayumi; Silva, Bárbara Pereira da; Soares, Filippe Elias de Freitas; Martino, Hércia Stampini Duarte; Queiróz, José Humberto de

doi:10.1039/c9fo00651f

Cited by 17 publications

(6 citation statements)

References 43 publications

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“…The favorable effects that have been seen are probably a result of the anti-inflammatory and antioxidant properties of the active compounds present in the mango leaf extract. The results agreed with those of Nadella and Kumar, (2016); Gazwi and Mahmoud, (2019);and Toledo et al, (2019).…”

Section: Discussionsupporting

confidence: 88%

Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Maghfur

Shahat

Soliman

2022

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Because synthetic antidiabetic medications have undesirable side effects and are expensive, various studies on medicinal plants with hypoglycemic properties have continued looking for alternative ways to prevent and manage type 2 diabetes (T2D) that may be more efficient, cost-effective and secure. Efficient bioactive substances such as flavonoids, tannins, alkaloids, terpenoids, anthraquinones, saponins, cardiac glycosides, and steroids were discovered in Mangifera indica leaves (MIL). The study's goal was to evaluate the MIL's therapeutic potential in diabetic rats treated with streptozotocin (STZ). In the experiment, forty male adult albino rats were employed. The animals were separated into four groups, each with ten rats, and evaluated as follows: group 1 (healthy control, HC); group 2 (untreated diabetic, UD); group 3 (mango treated diabetic, MTD); and group 4 (mango treated, MT). After 8 weeks of MIL extract administration, blood samples were taken to assess several biochemical and hematological markers. The treatment of MIL extract in diabetic rats resulted in significant reductions in blood glucose, glycated hemoglobin (HbA-1c), and amylase enzyme activity. The levels of insulin, vitamin C, and vitamin E were significantly increased with MIL extract treatment. Further, the extract showed significant antihyperlipidemic activity and renoprotective and hepatoprotective effects in diabetic rats. These findings suggested a beneficial effect of MIL extract in the treatment of T2D associated with hyperlipidemia, and liver and kidney complications.

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Section: Discussionsupporting

confidence: 88%

Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Maghfur

Shahat

Soliman

2022

Egyptian Academic Journal of Biological Sciences, B. Zoology

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“… 42 In addition, we have also found EEMI treated animals with increased levels of plasma IL-10, an endogenous anti-inflammatory protein which blocks TNF-α and IL-1 induced downstream signaling pathways. 43 It is highly evident through a number of in vivo studies 44 , 45 that the leaf and seed kernel extracts of M. Indica augmented plasma IL-10 and it might be due to the presence of gallotannins in seed kernel extracts of EEMI. 46 Whereas, expression levels of mRNAs of iNOS and eNOS in gastrocnemius muscles of animals treated with EEMI was contrary, where both doses of EEMI reduced the expression of mRNAs of iNOS and increased the expression of eNOS in a dose-dependent manner; and these results were also highly associated with reduced NO levels.…”

Section: Discussionmentioning

confidence: 99%

Peripheral arterial disease: Effects of ethanolic extracts of seed kernels of mango (Mangifera indica .L) on acute hind limb ischemia-reperfusion injury in diabetic rats

RamPravinKumar¹,

Dhananjayan²

2021

Journal of Traditional and Complementary Medicine

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Background and aim Hind limb ischemia is one of the peripheral arterial diseases affecting majority of the people with atherosclerosis, diabetes and chronic cigarette smokers. Hind limb ischemic-reperfusion injury is also one of the exacerbating events in these peoples, resulting in hind limb dysfunction. The aim of this study was to identify the effects of ethanolic extracts of mangifera indica (EEMI) on reversing hind limb dysfunction in diabetic rats with acute hind limb ischemia-reperfusion injury. Experimental procedure Unilateral femoral artery ligated diabetic rats were orally fed with EEMI (0.2 and 0.4 g/kg) for 14 days. At the end of the study, plasma levels of pro-inflammatory cytokines and relevant biochemical parameters were measured. The isolated gastrocnemius muscles were used for gene expression and histopathological studies. Results There was a significant reduction (p < 0.05) in the plasma levels of pro-inflammatory cytokines, nitric oxide, malondialdehyde; and the expression levels of mRNA of induced nitric oxide synthase and intercellular adhesion molecule −1; and increase in anti-inflammatory cytokine, in isolated gastrocnemius muscles of animals treated with 0.2 and 0.4 g/kg of EEMI in comparison to disease control. In addition, histopathological study of gastrocnemius muscle and hind limb function test indicated the recovery of tissue damage from ischemic reperfusion at 0.2 and 0.4 g/kg of EEMI in comparison to disease control. Conclusion We conclude that 14-day EEMI treatment of rats with acute hind limb ischemia/reperfusion in diabetic rats recovered from ischemic/reperfusion injury by modulating (decreasing) oxidative stress and inflammation.

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“…Scientific interest in the biological properties of Mangifera indica L. (Anacardiaceae) as a hypoglycemic agent has increased in recent years. Its leaves, and ashes of leaves, are widely used in folk medicine for DM treatment, inflammation, diarrhea, dysentery, leukocytosis, and burns [19,20,[21][22][23][24][25][26][27][28]29]. Ethnopharmacological studies have demonstrated that M. indica has been used for a long time in the worldwide treatment of DM [19].…”

Section: Introductionmentioning

confidence: 99%

Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats

et al. 2020

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Background Diabetes mellitus is one of the most common todays public health problems. According to a survey by the World Health Organization, this metabolic disorder has reached global epidemic proportions, with a worldwide prevalence of 8.5% in the adult population. Objectives The present study aimed to investigate the hypoglycemic effect of aqueous extract of Mangifera indica (EAMI) leaves in streptozotocin-induced diabetic rats. Methods Sixty male rats were divided into 2 groups: Normoglycemic and Diabetic. Each group was subdivided into negative control, glibenclamide 3 or 10 mg/kg, EAMI 125, 250, 500, and 1000 mg/kg. Intraperitoneal injection of streptozotocin 100 mg/kg was used to DM induction. The hypoglycemic response was assessed acutely after two and four weeks of treatment. After a 6-hour fasting period, the fasting blood glucose of animals was verified, and 2.5 g/kg glucose solution was orally administered. The insulin tolerance test and plasma insulin levels assessment were performed in the morning after fasting of 12 to 14 hours.

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Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet

Abstract: This study investigates the acute anti-inflammatory activity of Mangifera indica L. leaf extract and mangiferin in the liver of rats fed a cafeteria diet.

Cited by 17 publications

References 43 publications

Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Peripheral arterial disease: Effects of ethanolic extracts of seed kernels of mango (Mangifera indica .L) on acute hind limb ischemia-reperfusion injury in diabetic rats

Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats

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