Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Maghfur, Raga; Shahat, Mohamed; Soliman, Mohamed Y.

doi:10.21608/eajbsz.2022.265796

Cited by 2 publications

(1 citation statement)

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“…Mangifera indica Leaves extract had considerable antihyperlipidemic activity as well as renoprotective and hepatoprotective effects in diabetic albino rats, according to the study on Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats. (Maghfur et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

Alam,

Sheikh,

Samad

2023

Turkish JAF Sci.Tech.

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Background: In adults aged 30-70 with primary and moderate hyperlipidemia, the present study took place to investigate the therapeutic benefits of a polyherbal unani preparation called Garlitab. Methods: It was a prospective open label, herbal coded test drug-controlled, randomized trial. Out of total screened patients we were enrolled 212 hyperlipidemic patients of 30–70 years in the study fulfilling the inclusion criteria, we were recruited them from OPD of a hospital in Munshiganj and different Unani clinics of Dhaka, Bangladesh after obtaining written informed consent from the patients. Selected individuals were allocated into two groups at random. Group1 Received 500 mg Garlitab tablets twice daily and Group 2 received tablet atorvastatin calcium 10 mg 2 times daily. Height, weight, and blood pressure were recorded along with blood samples. The random distributions were carried out by a research assistant utilizing a random numbers table. Blood samples were taken at the beginning of the trial, 1.5 months later, and 3 months following the intervention. Results: Results for the test medication revealed a substantial drop in cholesterol levels between baseline and the data collected after three months and in case of male it was from 241.72±38.11 to 218.24±34.06 mg/dL for total cholesterol, from 198.27±30.57 to 173.54±29.34 mg/dL for LDL and from 280.78±85.81 to 207.07±51.40 mg/dL for triglyceride. HDL increases from 33.05±3.21 to 34.69±3.13 mg/dL in male patients. The control drug atorvastatin calcium also showed a significant decrease in lipids between baseline and after 3 months data and in case of male it was from 241.92±31.54 to 174.90±22.87 mg/dL for total cholesterol, from 196.20±30.91 to 130.30±24.29 mg/dL for LDL and from 279.48±115.35 to 141.27±59.55 mg/dL for triglyceride. It increases HDL from 32.00±2.25 to 34.03±2.19 mg/dL in male patients. Between the baseline and the 3-month data, the test medicine for females significantly reduced total cholesterol, LDL, and triglycerides and it was from 244.64±52.18 to 220.12±45.07 mg/dL, from 200.32±30.57 to 173.54±29.34 mg/dL and from 272.32±99.69 to 195.25±60.68 mg/dL respectively. HDL increases from 33.77±3.36 to 35.03±3.23 mg/dL. Between the baseline and the 3-month data, the control medication for females significantly reduced total cholesterol, LDL, and triglycerides and it was from 247.74±37.95 to 175.26±29.54 mg/dL, from 197.65±27.89 to 130.91±22.04 mg/dL and from 271.57±94.52 to 142.00±50.88 mg/dL respectively. It increases HDL from 32.22±2.32 to 33.46±2.94 mg/dL. Conclusions: According to the results of the study, the polyherbal formulation Garlitab can lower cholesterol levels. It may be a useful medication for treating primary hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

Alam,

Sheikh,

Samad

2023

Turkish JAF Sci.Tech.

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Hepatotoxicity Induced by Carbon Tetrachloride in Experimental Model

Munir

Khan

2023

PBMJ

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The present study is the first attempt to evaluate the hepatotoxicity induced by carbon tetrachloride (CCl4) in experimental model. It poses a significant hazard to one's health. It is also one of the leading sources of toxicity in critical organs such as the lungs, kidneys, liver, and brain. Objective: To assess the hepatotoxicity of carbon tetra chloride in albino rats. Methods: The research was conducted at the Department of Zoology, University of Okara. The experiment was conducted at the animal home of the Department of Zoology, University of Okara. There were two groups created: a control group and an experimental group. The experimental group was treated with CCl4. The rats were fed 30% diluted carbon tetrachloride with normal saline as a control group to test the harmful effect on the liver profile. This was accomplished through a 12-day trial. Sampling or dissection was done after 12 days. Rats were dissected, and their liver was punctured to obtain a blood sample and organ collection. After sampling was taken by puncturing the Rats' liver, the samples were examined by a machine called Micro-Lab 300. Results: Histopathological studies also proved that the liver of rats was damaged. The hepatotoxic dose of CCl4 also raised the serum AST, ALP, ALT, and bilirubin levels. Total levels of AST, ALP, ALT, and Bilirubin were higher than usual, indicating that CCl4 has a toxic effect on the liver profile of rats. Conclusions: This study suggested that CCl4 induced toxicity in rat liver.

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Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Cited by 2 publications

References 48 publications

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

Hepatotoxicity Induced by Carbon Tetrachloride in Experimental Model

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